Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Leonor Kremer"'
Autor:
Lidia Sanchez-Moral, Tony Paul, Clara Martori, Joan Font-Díaz, Lucía Sanjurjo, Gemma Aran, Érica Téllez, Julià Blanco, Jorge Carrillo, Masaoki Ito, Martina Tuttolomondo, Henrik J. Ditzel, Caterina Fumagalli, Gustavo Tapia, Julia Sidorova, Helena Masnou, Marco-Antonio Fernández-Sanmartín, Juan-José Lozano, Cristina Vilaplana, Alhelí Rodriguez-Cortés, Carolina Armengol, Annabel F. Valledor, Leonor Kremer, Maria-Rosa Sarrias
Publikováno v:
EBioMedicine, Vol 91, Iss , Pp 104555- (2023)
Summary: Background: Reprogramming of immunosuppressive tumor-associated macrophages (TAMs) presents an attractive therapeutic strategy in cancer. The aim of this study was to explore the role of macrophage CD5L protein in TAM activity and assess its
Externí odkaz:
https://doaj.org/article/36b0af9808e741e2b4807b241a0bfa38
Autor:
Silvia Santamaria, Marisa Delgado, Marta Botas, Eva Castellano, Isabel Corraliza-Gorjon, Paloma Lafuente, Cecilia Muñoz-Calleja, Maria L. Toribio, Leonor Kremer, Jose A. Garcia-Sanz
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Relapsed or refractory T acute lymphoblastic leukemia (T-ALL) still carries poor prognosis. Aiming to improve outcomes, the therapeutic potential of an anti-CCR9 monoclonal antibody (mAb 92R), targeting the human chemokine-receptor CCR9 is analyzed o
Externí odkaz:
https://doaj.org/article/e3c576e5a8ed43d38e3080ee69b7dc8f
Autor:
Cristina Bárcena, Gemma Aran, Luís Perea, Lucía Sanjurjo, Érica Téllez, Anna Oncins, Helena Masnou, Isabel Serra, Mónica García-Gallo, Leonor Kremer, Margarita Sala, Carolina Armengol, Pau Sancho-Bru, Maria-Rosa Sarrias
Publikováno v:
EBioMedicine, Vol 43, Iss , Pp 513-524 (2019)
Background: Chronic hepatic inflammation leads to liver fibrosis, which may progress to cirrhosis, a condition with high morbidity. Our aim was to assess the as yet unknown role of innate immunity protein CD5L in liver fibrosis. Methods: CD5L was mea
Externí odkaz:
https://doaj.org/article/0e0f1fe152c2492b8c597665316ea951
Autor:
Julia Pose-Utrilla, Lucía García-Guerra, Ana Del Puerto, Abraham Martín, Jerónimo Jurado-Arjona, Noelia S. De León-Reyes, Andrea Gamir-Morralla, Álvaro Sebastián-Serrano, Mónica García-Gallo, Leonor Kremer, Jens Fielitz, Christofer Ireson, Mª José Pérez-Álvarez, Isidro Ferrer, Félix Hernández, Jesús Ávila, Marina Lasa, Miguel R. Campanero, Teresa Iglesias
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Excitotoxicity due to excessive glutamate release causes oxidative stress and neuronal death, and is a feature of many brain diseases. Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its act
Externí odkaz:
https://doaj.org/article/cb128c406cd844578138ccf113906e62
Autor:
Leonor Kremer, Jose A. Garcia-Sanz
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/1bf03ae7319c474cb070ccb7c60320ba
Autor:
Beatriz Somovilla-Crespo, Maria Teresa Martín Monzón, Maria Vela, Isabel Corraliza-Gorjón, Silvia Santamaria, Jose A. Garcia-Sanz, Leonor Kremer
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
CCR9 is as an interesting target for the treatment of human CCR9+-T cell acute lymphoblastic leukemia, since its expression is limited to immature cells in the thymus, infiltrating leukocytes in the small intestine and a small fraction of mature circ
Externí odkaz:
https://doaj.org/article/a2199a2c03d74f5ca9a3c56fa8fec088
Autor:
Isabel Corraliza-Gorjón, Beatriz Somovilla-Crespo, Silvia Santamaria, Jose A. Garcia-Sanz, Leonor Kremer
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Antibodies have proven their high value in antitumor therapy over the last two decades. They are currently being used as the first-choice to treat some of the most frequent metastatic cancers, like HER2+ breast cancers or colorectal cancers, currentl
Externí odkaz:
https://doaj.org/article/325059f80fe24e1aa6c41b184b537b81
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The cancer stem cell (CSC) hypothesis suggests that within a tumor, there is a small subpopulation of cells with stem cell properties responsible for tumor maintenance and metastasis generation. This hypothesis also implies that new antitumor drugs,
Externí odkaz:
https://doaj.org/article/03eac51a28d34d71867045fe4ff6c1f5
Autor:
Julia Pose-Utrilla, Lucía García-Guerra, Ana Del Puerto, Abraham Martín, Jerónimo Jurado-Arjona, Noelia S. De León-Reyes, Andrea Gamir-Morralla, Álvaro Sebastián-Serrano, Mónica García-Gallo, Leonor Kremer, Jens Fielitz, Christofer Ireson, Mª José Pérez-Álvarez, Isidro Ferrer, Félix Hernández, Jesús Ávila, Marina Lasa, Miguel R. Campanero, Teresa Iglesias
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The original version of this Article contained an error in the spelling of the author Álvaro Sebastián-Serrano, which was incorrectly given as Álvaro Sebastián Serrano. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/60592296656942d89b1afe3ede1df2f3
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106685 (2014)
Foot-and-mouth disease virus non-structural protein 3A plays important roles in virus replication, virulence and host-range; nevertheless little is known on the interactions that this protein can establish with different cell components. In this work
Externí odkaz:
https://doaj.org/article/717366b7b1514bc1aa7bd3ca4e05cf7b