Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model

Autor: Leonor Côrte-Real, Ana Rita Brás, Adhan Pilon, Nuno Mendes, Ana Sofia Ribeiro, Tiago D. Martins, José Paulo S. Farinha, M. Conceição Oliveira, Fátima Gärtner, M. Helena Garcia, Ana Preto, Andreia Valente

Publikováno v: Pharmaceutics, Vol 14, Iss 7, p 1388 (2022)

The need for new therapeutic approaches for triple-negative breast cancer is a clinically relevant problem that needs to be solved. Using a multi-targeting approach to enhance cancer cell uptake, we synthesized a new family of ruthenium(II) organomet

Externí odkaz: https://doaj.org/article/288abacbd54c421c85e6044ef7572fda

Heteroleptic enantiopure Pd(ii)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine

Autor: Mohammed Enamullah, Nicola Micale, Mohammad Khairul Islam, Leonor Côrte-Real, Jason D. Braun, Andreia Valente, Johan Wouters, Nazanin Kordestani, Hadi Amiri Rudbari, Isabel Correia, David E. Herbert, Nikolay Tumanov

Publikováno v: New Journal of Chemistry. 45(20):9163-9180

Seven enantiomeric pairs of palladium complexes, [Pd(pic)(R or S)-N-1-(phenyl)ethyl-2,4-X1,X2-salicylaldiminate)]NO3, [Pd(pic)(R or S)]NO3 (X1 = X2 = Cl, Br, I, H; X1/X2 = Br/Cl), were synthesized by the reaction of enantiopure halogen-substituted Sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfd71dddc454d2304ae462e9e972f15
https://doi.org/10.1039/d1nj01491a

Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications

Autor: Brian T. Buckley, Keith R. Cooper, Leonor Côrte-Real, Kristin R. Terez, Cathleen L. Doherty, Brittany F. Karas

Publikováno v: J Vis Exp

Metals and metal-based compounds comprise multifarious pharmaco-active and toxicological xenobiotics. From heavy metal toxicity to chemotherapeutics, the toxicokinetics of these compounds have both historical and modern-day relevance. Zebrafish have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6852d4f97b8bd884e9fe626089eca169
https://doi.org/10.3791/63587-v

Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand

Autor: Cathleen Doherty, Brian Buckley, Fernanda Marques, M. Helena Garcia, Leonor Côrte-Real, Patrícia Gírio, Alexis Moreno, Andreia Valente, Pierre Falson, Keith R. Cooper, Fernando Avecilla, Brittany F Karas

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 163, pp.853-863. ⟨10.1016/j.ejmech.2018.12.022⟩

International audience; Two new ruthenium complexes, [Ru(h 5-Cp)(PPh 3)(2,2'-bipy-4,4'-R)] þ with R ¼-CH 2 OH (Ru1) or dibiotin ester (Ru2) were synthesized and fully characterized. Both compounds were tested against two types of breast cancer cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd399c16284d8151c87ae642f1d0dd9
https://doi.org/10.1016/j.ejmech.2018.12.022

A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity Against Colorectal and Triple Negative Breast Cancer Cells

Autor: Paulo J. Costa, Adhan Pilon, Leonor Côrte-Real, Ana Rita Brás, Ana Preto, Fernando Avecilla, Andreia Valente, M. Helena Garcia

Publikováno v: RUC. Repositorio da Universidade da Coruña
instname
Molecules
Molecules, Vol 25, Iss 1592, p 1592 (2020)
Volume 25
Issue 7
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

A family of compounds with the general formula [Fe(&eta
5-C5H5)(CO)(PPh3)(NCR)]+ has been synthesized (NCR = benzonitrile (1)
4-hydroxybenzonitrile (2)
4-hydroxymethylbenzonitrile (3)
4-aminobenzonitrile (4)
4-bromobenzonitri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e5ae389086671bce749a372235c578
http://hdl.handle.net/2183/25357