Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Leonilda M B Santos"'
Autor:
Felipe von Glehn, Sven Jarius, Augusto C Penalva de Oliveira, Carlos Otávio Brandão, Alessandro S Farias, Alfredo Damasceno, Jorge Casseb, Adriel S Moraes, Ana Leda F Longhini, Klaus-Peter Wandinger, Benito P Damasceno, Brigitte Wildemann, Leonilda M B Santos
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39372 (2012)
INTRODUCTION: The seroprevalence of human T-cell leukemia virus type 1 (HTLV-1) is very high among Brazilians (1:200). HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP) is the most common neurological complication of HTLV-1 infec
Externí odkaz:
https://doaj.org/article/e2503798f27044c79892e47a50597e58
Autor:
Alessandro S Farias, Rafael L Talaisys, Yara C Blanco, Stefanie C P Lopes, Ana Leda F Longhini, Fernando Pradella, Leonilda M B Santos, Fabio T M Costa
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17849 (2011)
BACKGROUND: Experimental autoimmune encephalomyelitis (EAE) is used as an animal model for human multiple sclerosis (MS), which is an inflammatory demyelinating autoimmune disease of the central nervous system characterized by activation of Th1 and/o
Externí odkaz:
https://doaj.org/article/07c5219b02954eaaa33ef5095eb34ffe
Autor:
Yara C Blanco, Alessandro S Farias, Uta Goelnitz, Stefanie C P Lopes, Wagner W Arrais-Silva, Bruna O Carvalho, Rogério Amino, Gerhard Wunderlich, Leonilda M B Santos, Selma Giorgio, Fabio T M Costa
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3126 (2008)
BACKGROUND: Cerebral malaria (CM) is a syndrome characterized by neurological signs, seizures and coma. Despite the fact that CM presents similarities with cerebral stroke, few studies have focused on new supportive therapies for the disease. Hyperba
Externí odkaz:
https://doaj.org/article/a8a69cfc675d4dee9922d73c36ff33cd
Autor:
Amanda D. R. Lima, Breno B. Ferrari, Fernando Pradella, Rodrigo M. Carvalho, Sandra L. S. Rivero, Raphael P. S. Quintiliano, Matheus A. Souza, Natália S. Brunetti, Ana M. Marques, Irene P. Santos, Alessandro S. Farias, Elaine C. Oliveira, Leonilda M. B. Santos
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Dimethyl fumarate (DMF, Tecfidera) is an oral drug utilized to treat relapsing-remitting multiple sclerosis (MS). DMF treatment reduces disease activity in MS. Gastrointestinal discomfort is a common adverse effect of the treatment with DMF. This stu
Externí odkaz:
https://doaj.org/article/a24e492906b34ef39133420c7e883ba1
Autor:
Felipe von Glehn, Nathalie Pochet, Bibek Thapa, Radhika Raheja, Maria A. Mazzola, Sushrut Jangi, Vanessa Beynon, Junning Huang, Alessandro S. Farias, Anu Paul, Leonilda M. B. Santos, Roopali Gandhi, Gopal Murugaiyan, Howard L. Weiner, Clare M. Baecher-Allan
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8000
The purpose of this study was to examine whether myeloid dendritic cells (mDCs) from patients with multiple sclerosis (MS) and healthy controls (HCs) become similarly tolerogenic when exposed to IL-27 as this may represent a potential mechanism of au
Autor:
Vinícius O. Boldrini, Ana M. Marques, Raphael P. S. Quintiliano, Adriel S. Moraes, Carla R. A. V. Stella, Ana Leda F. Longhini, Irene Santos, Marília Andrade, Breno Ferrari, Alfredo Damasceno, Rafael P. D. Carneiro, Carlos Otávio Brandão, Alessandro S. Farias, Leonilda M. B. Santos
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundEmerging evidence of antibody-independent functions, as well as the clinical efficacy of anti-CD20 depleting therapies, helped to reassess the contribution of B cells during multiple sclerosis (MS) pathogenesis.ObjectiveTo investigate wheth
Autor:
Adriel S. Moraes, Vinicius O. Boldrini, Alliny C. Dionete, Marilia D. Andrade, Ana Leda F. Longhini, Irene Santos, Amanda D. R. Lima, Veronica A. P. G. Silva, Rafael P. C. Dias Carneiro, Raphael P. S. Quintiliano, Breno B. Ferrari, Alfredo Damasceno, Fernando Pradella, Alessandro S. Farias, Charles P. Tilbery, Renan B. Domingues, Carlos Senne, Gustavo B. P. Fernandes, Felipe von Glehn, Carlos Otavio Brandão, Carla R. A. V. Stella, Leonilda M. B. Santos
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Frontiers in Cellular Neuroscience, Vol 15 (2021)
BackgroundNeurofilament Light (NfL) chain levels in both cerebrospinal fluid (CSF) and serum have been correlated with the reduction of axonal damage in multiple sclerosis (MS) patients treated with Natalizumab (NTZ). However, little is known about t
Autor:
Vinícius O. Boldrini, Lucas Scardua Silva, Leonilda M. B. Santos, Raphael P. S. Quintiliano, Alessandro S. Farias, Alfredo Damasceno
Publikováno v:
Multiple sclerosis and related disorders. 52
Recently, it was shown that highly effective anti-CD20 therapies used for MS patients not only deplete CD20+ B cells, but also a small subset of T cells expressing CD20 surface marker (CD3+CD20+ T cells). Here we demonstrated that, in progressive MS
Autor:
Natália S. Brunetti, Gustavo G. Davanzo, Diogo de Moraes, Allan J. R. Ferrari, Gabriela F. de Souza, Stefanie P. Muraro, Thiago L. Knittel, Vinícius O. Boldrini, Lauar B. Monteiro, João Victor Virgilio-da-Silva, Gerson S. Profeta, Natália S. Wassano, Luana N. Santos, Victor C. Carregari, Artur H. S. Dias, Flavio P. Veras, Lucas A. Tavares, Julia Forato, Ícaro Castro, Lícia C. Silva-Costa, Andre Palma, Eli Mansour, Raisa G. Ulaf, Ana F. Bernardes, Thyago A. Nunes, Luciana C. Ribeiro, Marcus V. Agrela, Maria Luiza Moretti, Lucas I. Buscaratti, Fernanda Crunfli, Raissa G. Ludwig, Jaqueline A. Gerhardt, Natália Munhoz-Alves, Ana M. Marques, Renata Sesti-Costa, Mariene R. Amorim, Daniel A. T. Texeira, Pierina L. Parise, Matheus C. Martini, Karina Bispo-dos-Santos, Camila L. Simeoni, Fabiana Granja, Virginia C. Silvestrini, Eduardo B. de Oliveira, Vitor M. Faça, Murilo Carvalho, Bianca G. Castelucci, Alexandre B. Pereira, Laís D. Coimbra, Marieli M. G. Dias, Patricia B. Rodrigues, Arilson Bernardo S. P. Gomes, Fabricio B. Pereira, Leonilda M. B. Santos, Louis-Marie Bloyet, Spencer Stumpf, Marjorie C. Pontelli, Sean P. J. Whelan, Andrei C. Sposito, Robson F. Carvalho, Andre S. Vieira, Marco A. R. Vinolo, André Damasio, Licio A. Velloso, Ana Carolina M. Figueira, Luis L. P. da Silva, Thiago M. Cunha, Helder I. Nakaya, Henrique Marques-Souza, Rafael E. Marques, Daniel Martins-de-Souza, Munir S. Skaf, José Luiz Proença-Modena, Pedro M. Moraes-Vieira, Marcelo A. Mori, Alessandro S. Farias
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as coronavirus disease-2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b49e3d26217034992f6c78cbd5605f51
https://doi.org/10.1101/2020.09.25.20200329
https://doi.org/10.1101/2020.09.25.20200329
Autor:
Aline Vidal, Maria Lucia Vellutini Pimentel, Carlos Otávio Brandão, Leonilda M. B. Santos, Letícia Fezer Mansur, Raphael P. S. Quintiliano, Alessandro S. Farias, Vinícius O. Boldrini
Publikováno v:
Journal of neuroimmunology. 340
Our group is interested in the cytotoxic mechanism during autoimmune neuroinflammation. Unexpectedly, we come across a case that presents a massive enhancement of cytotoxic behavior in lymphocytes, either in peripheral blood and cerebrospinal fluid.