Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals

Autor: Tao Yu, Yongjin J. Zhou, Leonie Wenning, Quanli Liu, Anastasia Krivoruchko, Verena Siewers, Jens Nielsen, Florian David

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Production of chemicals by microbial fermentation is an economical alternative to chemical synthesis. Here the authors re-engineer the yeastS. cerevisiaeto produce the very long chain fatty alcohol docosanol by expressing a heterologous Mycobacteria

Externí odkaz: https://doaj.org/article/36f3a67ebbcd46798748b17bc28b8b18

Production of moth sex pheromones for pest control by yeast fermentation

Autor: Bruno Sommer Ferreira, William H. Urrutia, Lucas Martins França, Marie Inger Dam, Kanchana Rueksomtawin Kildegaard, Bao-Jian Ding, Karolis Petkevicius, Bettina Lorantfy, Marina Pires, Carmem R. Bernardi, Hong-Lei Wang, Eleni Koutsoumpeli, Dimitris Raptopoulos, Irina Borodina, Maria Konstantopoulou, Christina Sinkwitz, Agenor Mafra-Neto, Leonie Wenning, Christer Löfstedt, Carina Holkenbrink

Publikováno v: Metabolic Engineering
Holkenbrink, C, Ding, B J, Wang, H L, Dam, M I, Petkevicius, K, Kildegaard, K R, Wenning, L, Sinkwitz, C, Lorántfy, B, Koutsoumpeli, E, França, L, Pires, M, Bernardi, C, Urrutia, W, Mafra-Neto, A, Ferreira, B S, Raptopoulos, D, Konstantopoulou, M, Löfstedt, C & Borodina, I 2020, ' Production of moth sex pheromones for pest control by yeast fermentation ', Metabolic Engineering, vol. 62, pp. 312-321 . https://doi.org/10.1016/j.ymben.2020.10.001

The use of insect sex pheromones is an alternative technology for pest control in agriculture and forestry, which, in contrast to insecticides, does not have adverse effects on human health or environment and is efficient also against insecticide-res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefd92aaea21ec2be2f7ff3b22d49849
https://doi.org/10.1016/j.ymben.2020.10.001

Increasing jojoba-like wax ester production in Saccharomyces cerevisiae by enhancing very long-chain, monounsaturated fatty acid synthesis

Autor: Florian David, Jens Nielsen, Christer S. Ejsing, Richard R. Sprenger, Verena Siewers, Leonie Wenning

Publikováno v: Microbial Cell Factories
Wenning, L, Ejsing, C S, David, F, Sprenger, R R, Nielsen, J & Siewers, V 2019, ' Increasing jojoba-like wax ester production in Saccharomyces cerevisiae by enhancing very long-chain, monounsaturated fatty acid synthesis ', Microbial Cell Factories, vol. 18, no. 49, 49 . https://doi.org/10.1186/s12934-019-1098-9
Wenning, L, Ejsing, C S, David, F, Sprenger, R R, Nielsen, J & Siewers, V 2019, ' Increasing jojoba-like wax ester production in Saccharomyces cerevisiae by enhancing very long-chain, monounsaturated fatty acid synthesis ', Microbial Cell Factories, vol. 18, no. 1, 49 . https://doi.org/10.1186/s12934-019-1098-9
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-17 (2019)

Background: Fatty acids (FAs) with a chain length of more than 18 carbon atoms (> C18) are interesting for the production of specialty compounds derived from these FAs. These compounds include free FAs, like erucic acid (C22:1-Δ13), primary fatty al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac329d561f4f0670a567a35a687aec4
https://doi.org/10.1186/s12934-019-1098-9

Investigation of putative regulatory acetylation sites in Fas2p ofSaccharomyces cerevisiae

Autor: Alexandra Linda Bergman, Verena Siewers, Leonie Wenning, Jens Nielsen

Yeast metabolism is highly regulated, in part via coordinated reprogramming of metabolism on a transcriptional level, for example in response to environmental changes. Furthermore, regulation occurs on the protein level via posttranslational modifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636fe3a5c4c2cb654206b03764c3604a
https://doi.org/10.1101/430918

Establishing very long-chain fatty alcohol and wax ester biosynthesis in Saccharomyces cerevisiae

Autor: Leonie, Wenning, Tao, Yu, Florian, David, Jens, Nielsen, Verena, Siewers

Publikováno v: Biotechnology and bioengineering. 114(5)

Wax esters (WEs) are neutral lipids and can be used for a broad range of commercial applications, including personal care products, lubricants, or coatings. They are synthesized by enzymatic reactions catalyzed by a fatty acyl reductase (FAR) and a w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa741315ee26532285ebd18aea311527
https://pubmed.ncbi.nlm.nih.gov/27858995