Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Leonie Schnell"'
Autor:
Manuel Schuster, Leonie Schnell, Peter Feigl, Carina Birkhofer, Katharina Mohr, Maurice Roeder, Stefan Carle, Simon Langer, Franziska Tippel, Johannes Buchner, Gunter Fischer, Felix Hausch, Manfred Frick, Carsten Schwan, Klaus Aktories, Cordelia Schiene-Fischer, Holger Barth
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which
Externí odkaz:
https://doaj.org/article/ae633d2015bd44bcb353d2cd6cd6a608
Autor:
Ziyu Zhu, Leonie Schnell, Bastian Müller, Martin Müller, Panagiotis Papatheodorou, Holger Barth
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Bacitracin is an established antibiotic for local application and inhibits the cell wall synthesis of Gram-positive bacteria. Recently, we discovered a completely different mode of action of bacitracin and reported that this drug protects human cells
Externí odkaz:
https://doaj.org/article/9f337e74b6d44c3696725cdc18f25879
Autor:
Leonie Schnell, Ann-Katrin Mittler, Andrea Mattarei, Domenico Azarnia Tehran, Cesare Montecucco, Holger Barth
Publikováno v:
Toxins, Vol 8, Iss 7, p 221 (2016)
Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) fro
Externí odkaz:
https://doaj.org/article/5d95b859ad814613b89d6e71e46bd7b6
Autor:
Leonie Schnell, Ann-Katrin Mittler, Mirko Sadi, Michel R. Popoff, Carsten Schwan, Klaus Aktories, Andrea Mattarei, Domenico Azarnia Tehran, Cesare Montecucco, Holger Barth
Publikováno v:
Toxins, Vol 8, Iss 4, p 101 (2016)
The pathogenic bacteria Clostridium difficile, Clostridium perfringens and Clostridium botulinum produce the binary actin ADP-ribosylating toxins CDT, iota and C2, respectively. These toxins are composed of a transport component (B) and a separate en
Externí odkaz:
https://doaj.org/article/f856a71baa684081927e2441a852324b
Autor:
Darran J Wigelsworth, Gordon Ruthel, Leonie Schnell, Peter Herrlich, Josip Blonder, Timothy D Veenstra, Robert J Carman, Tracy D Wilkins, Guy Tran Van Nhieu, Serge Pauillac, Maryse Gibert, Nathalie Sauvonnet, Bradley G Stiles, Michel R Popoff, Holger Barth
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51356 (2012)
Various pathogenic clostridia produce binary protein toxins associated with enteric diseases of humans and animals. Separate binding/translocation (B) components bind to a protein receptor on the cell surface, assemble with enzymatic (A) component(s)
Externí odkaz:
https://doaj.org/article/ca87b6b2d49e40aba41f55d994585e5a
Autor:
Eva Wirsching, Michael Fauler, Leonie Schnell, Bikram Keshari Agrawalla, Theresa Ostertag, Holger Barth, Seah Ling Kuan, Tanja Weil, Astrid Johanna Heck, Stephan Fischer, Manfred Frick, Pia Winterwerber
Publikováno v:
Advanced Healthcare Materials
The targeted pharmacological modulation of polymorphonuclear leukocytes (PMNs) is of major medical interest. These innate immune cells play a central role in the defense against pathogenic microorganisms. However, their excessive chemotactic recruitm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df221a41eb19014b3250123d53bcdcf8
https://hdl.handle.net/21.11116/0000-0005-4D58-321.11116/0000-0004-5D31-D
https://hdl.handle.net/21.11116/0000-0005-4D58-321.11116/0000-0004-5D31-D
Autor:
Holger Barth, Panagiotis Papatheodorou, Mirko Sadi, Michel R. Popoff, Leonie Schnell, Franziska von Bank, Ina Felix, Roland Benz, Michael Fauler, Eva Waltenberger, Bastian Müller, Klaus Aktories, Conrad Weichbrodt, Manfred Frick
Publikováno v:
FASEB Journal
FASEB Journal, 2019, 33 (4), pp.5755-5771. ⟨10.1096/fj.201802453R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2019, 33 (4), pp.5755-5771. ⟨10.1096/fj.201802453R⟩
FASEB Journal, 2019, 33 (4), pp.5755-5771. ⟨10.1096/fj.201802453R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2019, 33 (4), pp.5755-5771. ⟨10.1096/fj.201802453R⟩
International audience; The antibiotic bacitracin (Bac) inhibits cell wall synthesis of gram-positive bacteria. Here, we discovered a totally different activity of Bac: the neutralization of bacterial exotoxins. Bac prevented intoxication of mammalia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b919b5cea31038267bb996a286a2e61
https://hal-pasteur.archives-ouvertes.fr/pasteur-02453905
https://hal-pasteur.archives-ouvertes.fr/pasteur-02453905
Autor:
Stefan Carle, Simon Langer, Felix Hausch, Carina Birkhofer, Manuel Schuster, Cordelia Schiene-Fischer, Holger Barth, Manfred Frick, Maurice Roeder, Katharina B. Mohr, Johannes Buchner, Carsten Schwan, Franziska Tippel, Gunter Fischer, Peter Feigl, Klaus Aktories, Leonie Schnell
Publikováno v:
SCIENTIFIC REPORTS
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which might be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac48a405daaf83f62731a1fdd889a909
https://hdl.handle.net/11858/00-001M-0000-002D-845E-C11858/00-001M-0000-002D-8460-4
https://hdl.handle.net/11858/00-001M-0000-002D-845E-C11858/00-001M-0000-002D-8460-4
Autor:
Seah Ling Kuan, Astrid Johanna Heck, Stephan Fischer, Manfred Frick, Eva Wirsching, Pia Winterwerber, Tanja Weil, Leonie Schnell, Michael Fauler, Bikram Keshari Agrawalla, Theresa Ostertag, Holger Barth
Publikováno v:
Advanced Healthcare Materials. 8:1970072
Autor:
Ann-Katrin Mittler, Domenico Azarnia Tehran, Cesare Montecucco, Holger Barth, Leonie Schnell, Andrea Mattarei
Publikováno v:
Toxins, Vol 8, Iss 7, p 221 (2016)
Toxins; Volume 8; Issue 7; Pages: 221
Toxins
Toxins; Volume 8; Issue 7; Pages: 221
Toxins
Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) fro