Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Leonie S. Taams"'
Autor:
Benedict D. Michael, Cordelia Dunai, Edward J. Needham, Kukatharmini Tharmaratnam, Robyn Williams, Yun Huang, Sarah A. Boardman, Jordan J. Clark, Parul Sharma, Krishanthi Subramaniam, Greta K. Wood, Ceryce Collie, Richard Digby, Alexander Ren, Emma Norton, Maya Leibowitz, Soraya Ebrahimi, Andrew Fower, Hannah Fox, Esteban Tato, Mark A. Ellul, Geraint Sunderland, Marie Held, Claire Hetherington, Franklyn N. Egbe, Alish Palmos, Kathy Stirrups, Alexander Grundmann, Anne-Cecile Chiollaz, Jean-Charles Sanchez, James P. Stewart, Michael Griffiths, Tom Solomon, Gerome Breen, Alasdair J. Coles, Nathalie Kingston, John R. Bradley, Patrick F. Chinnery, Jonathan Cavanagh, Sarosh R. Irani, Angela Vincent, J. Kenneth Baillie, Peter J. Openshaw, Malcolm G. Semple, ISARIC4C Investigators, COVID-CNS Consortium, Leonie S. Taams, David K. Menon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days pos
Externí odkaz:
https://doaj.org/article/b91096b3ed5a4dec92a987b9259afe0a
Autor:
Benedict D. Michael, Cordelia Dunai, Edward J. Needham, Kukatharmini Tharmaratnam, Robyn Williams, Yun Huang, Sarah A. Boardman, Jordan J. Clark, Parul Sharma, Krishanthi Subramaniam, Greta K. Wood, Ceryce Collie, Richard Digby, Alexander Ren, Emma Norton, Maya Leibowitz, Soraya Ebrahimi, Andrew Fower, Hannah Fox, Esteban Tato, Mark A. Ellul, Geraint Sunderland, Marie Held, Claire Hetherington, Franklyn N. Egbe, Alish Palmos, Kathy Stirrups, Alexander Grundmann, Anne-Cecile Chiollaz, Jean-Charles Sanchez, James P. Stewart, Michael Griffiths, Tom Solomon, Gerome Breen, Alasdair J. Coles, Nathalie Kingston, John R. Bradley, Patrick F. Chinnery, Jonathan Cavanagh, Sarosh R. Irani, Angela Vincent, J. Kenneth Baillie, Peter J. Openshaw, Malcolm G. Semple, ISARIC4C Investigators, COVID-CNS Consortium, Leonie S. Taams, David K. Menon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/153c2bbad3eb4cb580f29e9a39f7205b
Autor:
Giovanni A.M. Povoleri, Lucy E. Durham, Elizabeth H. Gray, Sylvine Lalnunhlimi, Shichina Kannambath, Michael J. Pitcher, Pawan Dhami, Thomas Leeuw, Sarah E. Ryan, Kathryn J.A. Steel, Bruce W. Kirkham, Leonie S. Taams
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112514- (2023)
Summary: CD69+CD103+ tissue-resident memory T (TRM) cells are important drivers of inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high-dimensional profiling to T cells from the joints of patients with psoriatic
Externí odkaz:
https://doaj.org/article/7c887f70768745f6826a22484fb9b917
Autor:
Gerdien Mijnheer, Lisanne Lutter, Michal Mokry, Marlot van der Wal, Rianne Scholman, Veerle Fleskens, Aridaman Pandit, Weiyang Tao, Mark Wekking, Stephin Vervoort, Ceri Roberts, Alessandra Petrelli, Janneke G. C. Peeters, Marthe Knijff, Sytze de Roock, Sebastiaan Vastert, Leonie S. Taams, Jorg van Loosdregt, Femke van Wijk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
T regulatory (Treg) cells can differentiate into effector Treg (eTreg) cells that might be functional in inflammatory diseases. Using RNA sequencing and epigenetic profiling, the authors show that eTreg signatures in juvenile idiopathic arthritis joi
Externí odkaz:
https://doaj.org/article/0a5628b633d646d0b5877f5920381df7
Autor:
Alish B. Palmos, Vincent Millischer, David K. Menon, Timothy R. Nicholson, Leonie S. Taams, Benedict Michael, Geraint Sunderland, Michael J. Griffiths, COVID Clinical Neuroscience Study Consortium, Christopher Hübel, Gerome Breen
Publikováno v:
PLoS Genetics, Vol 18, Iss 3 (2022)
In November 2021, the COVID-19 pandemic death toll surpassed five million individuals. We applied Mendelian randomization including >3,000 blood proteins as exposures to identify potential biomarkers that may indicate risk for hospitalization or need
Externí odkaz:
https://doaj.org/article/9dbd921d309e4f908aae96c48370a471
Autor:
Esperanza Perucha, Rossella Melchiotti, Jack A Bibby, Wing Wu, Klaus Stensgaard Frederiksen, Ceri A. Roberts, Zoe Hall, Gaelle LeFriec, Kevin A. Robertson, Paul Lavender, Jens Gammeltoft Gerwien, Leonie S. Taams, Julian L. Griffin, Emanuele de Rinaldis, Lisa G. M. van Baarsen, Claudia Kemper, Peter Ghazal, Andrew P. Cope
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Metabolic pathways are increasingly recognized as crucial determinants of T cell function. Here the authors show that the balance between IFNγ and IL-10 production in human CD4 T cells is modulated by the cholesterol biosynthetic pathway.
Externí odkaz:
https://doaj.org/article/419107e4daf14adaaf778f8b200485e9
Autor:
Marijke I. Zonneveld, Martijn J.C. vanHerwijnen, Marcela M. Fernandez‐Gutierrez, Alberta Giovanazzi, Anne Marit deGroot, Marije Kleinjan, Toni M.M. vanCapel, Alice J.A.M. Sijts, Leonie S. Taams, Johan Garssen, Esther C. deJong, Michiel Kleerebezem, Esther N.M. Nolte‐’t Hoen, Frank A. Redegeld, Marca H.M. Wauben
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 5, Pp n/a-n/a (2021)
Abstract Maternal milk is nature's first functional food. It plays a crucial role in the development of the infant's gastrointestinal (GI) tract and the immune system. Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer enclo
Externí odkaz:
https://doaj.org/article/3263fcdb69c6450faab810bbd9cfce3f
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovial lining (synovitis). The inflammation in the RA joint is associated with and driven by immune cell infiltration, synovial hyperproliferation and
Externí odkaz:
https://doaj.org/article/87f53e09e4ee4e6996969e3f2e23a2ae
Autor:
Maia Kavanagh Williamson, Naomi Coombes, Florian Juszczak, Marios Athanasopoulos, Mariam B. Khan, Thomas R. Eykyn, Ushani Srenathan, Leonie S. Taams, Julianna Dias Zeidler, Andrea T. Da Poian, Hendrik Huthoff
Publikováno v:
Viruses, Vol 10, Iss 3, p 114 (2018)
Infection of primary CD4+ T cells with HIV-1 coincides with an increase in glycolysis. We investigated the expression of glucose transporters (GLUT) and glycolytic enzymes in human CD4+ T cells in response to infection with HIV-1. We demonstrate the
Externí odkaz:
https://doaj.org/article/53c93b8cede846ac9ada316bfb8b1ac1
Autor:
Zoe Rutter-Locher, Nikita Arumalla, Sam Norton, Leonie S. Taams, Bruce W. Kirkham, Kirsty Bannister
Publikováno v:
Seminars in Arthritis and Rheumatism. 61:152207