Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Leonie S. Lautz"'
Autor:
Leonie S. Lautz, Franca M. Buratti, Emma Di Consiglio, Jean-Lou Dorne, Laura Turco, Camille Béchaux, Susanna Vichi, Emanuela Testai, K. Darney
Publikováno v:
Toxicology Letters
Toxicology Letters, Elsevier, 2020, 337, pp.78-90. ⟨10.1016/j.toxlet.2020.11.007⟩
Toxicology Letters, Elsevier, 2020, 337, pp.78-90. ⟨10.1016/j.toxlet.2020.11.007⟩
International audience; The input into the QIVIVE and Physiologically-Based kinetic and dynamic models of drug metabolising enzymes performance and their inter-individual differences significantly improve the modelling performance, supporting the dev
Autor:
Emanuela Testai, Laura Turco, K. Darney, Susanna Vichi, E. Di Consiglio, Franca M. Buratti, Jean-Lou Dorne, Leonie S. Lautz
Publikováno v:
Toxicology Letters
Toxicology Letters, Elsevier, 2021, 350, pp.162-170. ⟨10.1016/j.toxlet.2021.07.005⟩
Toxicology Letters, 350, 162-170
Toxicology Letters 350 (2021)
Toxicology Letters, Elsevier, 2021, 350, pp.162-170. ⟨10.1016/j.toxlet.2021.07.005⟩
Toxicology Letters, 350, 162-170
Toxicology Letters 350 (2021)
International audience; Carboxylesterases (CES) are an important class of enzymes involved in the hydrolysis of a range of chemicals and show large inter-individual variability in vitro. An extensive literature search was performed to identify in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89e4775f71c62e7a6b5c7a047320ed8
https://hal-anses.archives-ouvertes.fr/anses-03322529/document
https://hal-anses.archives-ouvertes.fr/anses-03322529/document
Autor:
Laura Turco, Leonie S. Lautz, K. Darney, Jean-Lou Dorne, Emanuela Testai, Franca M. Buratti, Susanna Vichi, Emma Di Consiglio
Publikováno v:
Toxicology Letters
Toxicology Letters, Elsevier, 2021, ⟨10.1016/j.toxlet.2021.07.019⟩
Toxicology Letters, Elsevier, 2021, ⟨10.1016/j.toxlet.2021.07.019⟩
International audience; The open source database "OpenCYP database" has been developed based on the results of extensive literature searches from the peer-reviewed literature. OpenCYP provides data on human variability on baseline of activities and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d2aa3a48e299b0e02118b207d50ddd
https://hal-anses.archives-ouvertes.fr/anses-03319826/file/Vichi_2021.pdf
https://hal-anses.archives-ouvertes.fr/anses-03319826/file/Vichi_2021.pdf
Autor:
Emma Di Consiglio, Emanuela Testai, Zoi-Vasiliki Skaperda, Emma E.J. Kasteel, Nicoletta Santori, Susanna Vichi, Keyvin Darney, Laura Turco, Nynke I. Kramer, Dimitrios Kouretas, Franca M. Buratti, Camille Béchaux, Leonie S. Lautz
Publikováno v:
EFSA Supporting Publications. 18
Autor:
Leonie S. Lautz, Tom M. Nolte, A. Jan Hendriks, K. Remon Koopman, Leo Posthuma, Rob S. E. W. Leuven, Jiaqi Wang
Publikováno v:
Journal of Environmental Management, 281, 1-9
Journal of Environmental Management
Journal of Environmental Management, Elsevier, 2020, 281, pp.111873. ⟨10.1016/j.jenvman.2020.111873⟩
Journal of Environmental Management, 281, pp. 1-9
Journal of Environmental Management
Journal of Environmental Management, Elsevier, 2020, 281, pp.111873. ⟨10.1016/j.jenvman.2020.111873⟩
Journal of Environmental Management, 281, pp. 1-9
International audience; Chemical pollution impinges on the quality of water systems and the ecosystem services (ESs) they provide. Expression of ESs in monetary units has become an essential tool for sustainable ecosystem management. However, the imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd3a61aba054fdb6f212846a766b486
http://hdl.handle.net/2066/231437
http://hdl.handle.net/2066/231437
Autor:
Jean-Lou Dorne, Laura Turco, Camille Béchaux, K. Darney, Leonie S. Lautz, E. Di Consiglio, Emanuela Testai, A.C. Roudot, Susanna Vichi, Franca M. Buratti
Publikováno v:
Food and Chemical Toxicology
Food and Chemical Toxicology, Elsevier, 2020, 140, pp.111305-. ⟨10.1016/j.fct.2020.111305⟩
Food and Chemical Toxicology, Elsevier, 2020, 140, pp.111305-. ⟨10.1016/j.fct.2020.111305⟩
Transporters are divided into the ABC and SLC super-families, mediating the cellular efflux and influx of various xenobiotic and endogenous substrates. Here, an extensive literature search was performed to identify in vivo probe substrates for P-gp,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a9e4a40886decbb0488a0976bfd7b4
https://hal.archives-ouvertes.fr/hal-03490480
https://hal.archives-ouvertes.fr/hal-03490480
Publikováno v:
Toxicology Letters
Toxicology Letters, Elsevier, 2021, 337, pp.111-120. ⟨10.1016/j.toxlet.2020.11.016⟩
Toxicology Letters, 2021, 337, pp.111-120. ⟨10.1016/j.toxlet.2020.11.016⟩
Toxicology Letters, Elsevier, 2021, 337, pp.111-120. ⟨10.1016/j.toxlet.2020.11.016⟩
Toxicology Letters, 2021, 337, pp.111-120. ⟨10.1016/j.toxlet.2020.11.016⟩
International audience; Quantifying variability in pharmacokinetics (PK) and toxicokinetics (TK) provides a science-based approach to refine uncertainty factors (UFs) for chemical risk assessment. In this context, genetic polymorphisms in cytochromes
Autor:
Jean-Lou Dorne, Philippe Verger, J. Tarazona, Gaud Dervilly, Leonie S. Lautz, M. C. Astuto, K. Darney, B. Le Bizec, A. K. D. Liem, Luc Ingenbleek, George E.N. Kass, Jean-Charles Leblanc
In the modern world, chemicals are ubiquitous, and humans, animals and species in the environment are exposed to an increasing number, both of anthropogenic and natural origin. Chemical risk assessment in the food and feed safety areas involves a wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b99d0f5cc3de377066731a8e0fcd594
https://doi.org/10.1039/9781839160431-00001
https://doi.org/10.1039/9781839160431-00001
Autor:
Camille Béchaux, Witold Więcek, Jean-Lou Dorne, Emanuela Testai, Kevin Darney, Billy Amzal, Leonie S. Lautz
Publikováno v:
Environment International
Environment International, Elsevier, 2021, 156, ⟨10.1016/j.envint.2021.106760⟩
Environment International, Vol 156, Iss, Pp 106760-(2021)
Environment International, Elsevier, 2021, 156, ⟨10.1016/j.envint.2021.106760⟩
Environment International, Vol 156, Iss, Pp 106760-(2021)
International audience; The major human cytochrome P450 CYP2D6 isoform enzyme plays important roles in the liver and in the brain with regards to xenobiotic metabolism. Xenobiotics as CYP2D6 substrates include a whole range of pharmaceuticals, pestic
Autor:
Witold Więcek, Ad M.J. Ragas, Leonie S. Lautz, Nynke I. Kramer, Nadia Quignot, Rémy Beaudouin, Camille Béchaux, E. Di Consiglio, Laura Turco, J. Cortinas-Abrahantes, Judith C. Madden, Tobin Robinson, Franca M. Buratti, Emma E.J. Kasteel, Billy Amzal, Rik Oldenkamp, Alicia Paini, K. Darney, Frédéric Y. Bois, A. Grech, Jean-Lou Dorne, Emanuela Testai, Susanna Vichi, Céline Brochot, Cleo Tebby
Publikováno v:
54. Congress of the European Societies of Toxicology (EUROTOX 2018)
54. Congress of the European Societies of Toxicology (EUROTOX 2018), Sep 2018, Bruxelles, Belgium. pp.S5, ⟨10.1016/j.toxlet.2018.06.023⟩
54. Congress of the European Societies of Toxicology (EUROTOX 2018), Sep 2018, Bruxelles, Belgium. pp.S5, ⟨10.1016/j.toxlet.2018.06.023⟩
International audience; requirements for pre-market authorisation of pesticides (regulation 283-284/2013) for which comparative in vitro metabolism (rat) human and in vivo rat TK data are required. As a consequence, EFSA has been involved in collabor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe72f1d17df4b1a2b69b8f20c7c7eac
https://hal-ineris.archives-ouvertes.fr/ineris-03224934
https://hal-ineris.archives-ouvertes.fr/ineris-03224934