Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Leonie Ringrose"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Polycomb (PcG) and Trithorax (TrxG) group regulate several hundred target genes with important roles in development and disease. Here the authors combine experiment and theory to provide evidence that the Polycomb/Trithorax system has the potential f
Externí odkaz:
https://doaj.org/article/c081d1c5a15a439ca97b4307c27e34a7
Autor:
Kim Sneppen, Leonie Ringrose
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Polycomb and Trithorax group proteins regulate silent and active gene expression states, but also allow poised states in pluripotent cells. Here the authors present a mathematical model that integrates data on Polycomb/ Trithorax biochemistry into a
Externí odkaz:
https://doaj.org/article/344a9aa5671646888fbae5c488d5080b
Publikováno v:
PLoS Biology, Vol 6, Iss 10, p e261 (2008)
cis-Regulatory DNA elements contain multiple binding sites for activators and repressors of transcription. Among these elements are enhancers, which establish gene expression states, and Polycomb/Trithorax response elements (PREs), which take over fr
Externí odkaz:
https://doaj.org/article/f1944e5689454a329b718b3524aaa1aa
Autor:
Christina Altmutter, Attila Gyenesei, Leonie Ringrose, Philipp A. Steffen, Eva Dworschak, Xinzhou Zhu, Tobias Kockmann, Sini Junttila
Publikováno v:
Chromosoma
The Drosophila Trithorax group (TrxG) protein ASH1 remains associated with mitotic chromatin through mechanisms that are poorly understood. ASH1 dimethylates histone H3 at lysine 36 via its SET domain. Here, we identify domains of the TrxG protein AS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd7a906efa89968601279d73d2ec2d1
https://pubmed.ncbi.nlm.nih.gov/34331109
https://pubmed.ncbi.nlm.nih.gov/34331109
Autor:
Leonie Ringrose
Publikováno v:
Annual Review of Genetics. 51:385-411
The question of how noncoding RNAs are involved in Polycomb group (PcG) and Trithorax group (TrxG) regulation has been on an extraordinary journey over the last three decades. Favored models have risen and fallen, and healthy debates have swept back
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3373ca5973444516a406281b4c872d89
https://doi.org/10.1146/annurev-genet-120116-023402
https://doi.org/10.1146/annurev-genet-120116-023402
Autor:
Leonie Ringrose, Martin Howard
Publikováno v:
Current Opinion in Systems Biology. 3:7-14
The application of mathematical modelling to chromatin-mediated gene regulation is gaining momentum, but is still surprisingly rare. Here we review examples in which the combination of quantitative experimentation and mathematical modelling has given
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46200ef2c64f96ac21008f43d4e912c2
https://doi.org/10.1016/j.coisb.2017.02.003
https://doi.org/10.1016/j.coisb.2017.02.003
Autor:
Attila Gyenesei, Isabella Tsai, Christine Ehrhardt, Leonie Ringrose, Karl Mechtler, Luiza Deszcz, Tomoko Asaoka, Kay Hofmann, Anoop Kavirayani, Jorge Almagro, Peter Duchek, Sini Junttila, Katrin Rittinger, Fumiyo Ikeda, Alexander Schleiffer
Publikováno v:
EMBO Reports
The HOIP ubiquitin E3 ligase generates linear ubiquitin chains by forming a complex with HOIL‐1L and SHARPIN in mammals. Here, we provide the first evidence of linear ubiquitination induced by a HOIP orthologue in Drosophila. We identify Drosophila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7506073c75d048d33a5db6524e4f28e4
http://europepmc.org/articles/PMC5090701
http://europepmc.org/articles/PMC5090701
Publikováno v:
Chromosoma
A long-standing mystery in the field of Polycomb and Trithorax regulation is how these proteins, which are highly conserved between flies and mammals, can regulate several hundred equally highly conserved target genes, but recognise these targets via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2a794e0e3b612a3439f2b8e0bb9580
http://europepmc.org/articles/PMC4901126
http://europepmc.org/articles/PMC4901126
Autor:
Leonie Ringrose
Epigenetics and Systems Biology highlights the need for collaboration between experiments and theoretical modeling that is required for successful application of systems biology in epigenetics studies. This book breaks down the obstacles which exist
