Výsledky vyhledávání - "Leonie Majunke"

Akademický článek

Whole blood microRNAs as potential biomarkers in post-operative early breast cancer patients

Autor: Marianna Alunni-Fabbroni, Leonie Majunke, Elisabeth K. Trapp, Marie Tzschaschel, Sven Mahner, Peter A. Fasching, Tanja Fehm, Andreas Schneeweiss, Thomas Beck, Ralf Lorenz, Thomas W. P. Friedl, Wolfgang Janni, Brigitte Rack, on behalf of the SUCCESS Study Group

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)

Abstract Background microRNAs (miRNAs) are considered promising cancer biomarkers, showing high reliability, sensitivity and stability. Our study aimed to identify associations between whole blood miRNA profiles, presence of circulating tumor cells (

Externí odkaz: https://doaj.org/article/35021f3d4cbf4fba95d7c6d5747e931e

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Abstract 3471: A function-based high-throughput discovery platform, myeloid iOTarg, identifies novel immune checkpoints of the tumor microenvironment

Autor: Kritika Sudan, Tillmann Michels, Carmen Amerhauser, Claudia Tschulik, Leonie Majunke, Lucille Albert, Valentina Volpin, Adriana Turqueti-Neves, Ronny Milde, Nisit Khandelwal

Publikováno v: Cancer Research. 83:3471-3471

Tumor-associated macrophages (TAMs) are important players to maintain immunosuppression within the tumor microenvironment (TME) and attenuate the function of effector immune cells to promote tumor survival. High density of TAMs is well-recognized as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33870c7919a3ebcd33b799b7a09065d2
https://doi.org/10.1158/1538-7445.am2023-3471

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Akademický článek

Estrogen Receptor and HER2 Status on Disseminated Tumor Cells and Primary Tumor in Patients with Early Breast Cancer

Autor: Bernadette A.S. Jäger, Charlotte Finkenzeller, Carolin Bock, Leonie Majunke, Julia K. Jueckstock, Ulrich Andergassen, Julia K. Neugebauer, Aurelia Pestka, Thomas W.P. Friedl, Udo Jeschke, Wolfgang Janni, Sophie F. Doisneau-Sixou, Brigitte K. Rack

Publikováno v: Translational Oncology, Vol 8, Iss 6, Pp 509-516 (2015)

BACKGROUND: We evaluated both estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) status on disseminated tumor cells (DTCs) in the bone marrow of 54 patients with early breast cancer and compared these with the corresponding pr

Externí odkaz: https://doaj.org/article/b76ad74c8490456398f6deb59267e44b

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LKB1 pro-oncogenic activity triggers cell survival in circulating tumor cells

Autor: Thomas Wolfram Paul Friedl, Leonie Majunke, Elisabeth Trapp, Sven Mahner, Marianna Alunni-Fabbroni, Beate Zill, Julian Koch, Wolfgang Janni, Nadia Harbeck, Brigitte Rack, Harald Sommer, Ulrich Andergassen

Publikováno v: Molecular Oncology

During intravasation, circulating tumor cells (CTCs) detach from the epithelium of origin and begin the epithelial‐to‐mesenchymal transition (EMT) process, where they lose epithelial features and pass through the endothelium to enter circulation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e34a7835d3643768347ef674a595912
https://doi.org/10.1002/1878-0261.12111

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Abstract P4-07-01: Profiling miRNA in high risk post-operative early breast cancer patients to detect possible association to correlation with immune system antitumor response

Autor: E Trapp, Wolfgang Janni, S Mahner, Arkadius Polasik, Leonie Majunke, M Tzschaschel, Andreas Schneeweiss, Tanja Fehm, Marianna Alunni-Fabbroni, PA Fasching, Brigitte Rack, Twp Friedl

Publikováno v: Cancer Research. 77:P4-07

Aims: Identifying which patient will be the one who developes metastatis or relapses is still an unsolved problem in breast cancer research. Circulating free nuclei acids such as microRNA (miRNA) are very promising cancer biomarkers to detect those p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed715e0fda19d2f0a7f801a400364c4d
https://doi.org/10.1158/1538-7445.sabcs16-p4-07-01

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Whole blood microRNAs as potential biomarkers in post-operative early breast cancer patients

Autor: Wolfgang Janni, Leonie Majunke, Tanja Fehm, Sven Mahner, Ralf Lorenz, Thomas L. Beck, Elisabeth Trapp, Marie Tzschaschel, Marianna Alunni-Fabbroni, Andreas Schneeweiss, Thomas W. P. Friedl, Brigitte Rack, Peter A. Fasching

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
BMC Cancer

Background microRNAs (miRNAs) are considered promising cancer biomarkers, showing high reliability, sensitivity and stability. Our study aimed to identify associations between whole blood miRNA profiles, presence of circulating tumor cells (CTCs) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb378d6a8f6075fc78f5ed12e1c488c4
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/9696

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Estrogen Receptor and HER2 Status on Disseminated Tumor Cells and Primary Tumor in Patients with Early Breast Cancer

Autor: Thomas W. P. Friedl, Bernadette Jäger, Sophie F. Doisneau-Sixou, Wolfgang Janni, Julia Neugebauer, Julia Kathrin Jueckstock, Aurelia Pestka, Charlotte Finkenzeller, Leonie Majunke, Brigitte Rack, Udo Jeschke, Ulrich Andergassen, Carolin Bock

Publikováno v: Translational Oncology
Translational Oncology, Vol 8, Iss 6, Pp 509-516 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d575ccb87b80e80b24d4f9faa5cb00
https://doi.org/10.1016/j.tranon.2015.11.009

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Abstract P1-04-06: Discordance of the ER- and HER2-status on disseminated tumor cells compared to the primary tumor in patients with early breast cancer

Autor: A Pestka, Udo Jeschke, Wolfgang Janni, Julia Neugebauer, C Finkenzeller, Carolin Bock, Twp Friedl, Leonie Majunke, Julia Kathrin Jueckstock, Brigitte Rack, Bas Jaeger, Sophie F. Doisneau-Sixou, Ulrich Andergassen

Publikováno v: Cancer Research. 73:P1-04

Background: Differences in ER- and HER2-expression on metastases compared to the primary tumor (PT) are a known phenomenon and may have clinical implications in respect of targeted systemic treatment approaches. The aim of this study was to evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::855e7a381d1245c45c9a27c133bd5539
https://doi.org/10.1158/0008-5472.sabcs13-p1-04-06

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LKB1 and its importance for survival in EpCAM negative circulating tumor cells (CTC) in metastatic breast cancer

Autor: Elisabeth Trapp, Wolfgang Janni, Sven Mahner, Nadia Harbeck, Brigitte Rack, Marianna Alunni-Fabbroni, Leonie Majunke, Thomas W. P. Friedl, M Tzschaschel, Julian Koch, Ulrich Andergassen, Beate Zill, A. Kurt

Publikováno v: Journal of Clinical Oncology. 35:e23061-e23061

e23061 Background: To reach distant sites, CTC overcome metabolic stress and acquire a mesenchymal phenotype. So we assessed the pro survival function of liver kinase B1 (LKB1) a cellular metabolic stress controller, in combination with the EMT trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebcb0720319fc120fd5b59d3914a85e9
https://doi.org/10.1200/jco.2017.35.15_suppl.e23061

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