Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Leonie M. Quinn"'
Autor:
Agalya Periasamy, Naomi Mitchell, Olga Zaytseva, Arjun S. Chahal, Jiamin Zhao, Peter M. Colman, Leonie M. Quinn, Jacqueline M. Gulbis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Intronic polymorphic TOMM40 variants increasing TOMM40 mRNA expression are strongly correlated to late onset Alzheimer’s Disease. The gene product, hTomm40, encoded in the APOE gene cluster, is a core component of TOM, the translocase that
Externí odkaz:
https://doaj.org/article/152d29d679174b4dbdb60b58aa7f1c2c
Autor:
Linda M. Parsons, Nicola A. Grzeschik, Kasun Amaratunga, Peter Burke, Leonie M. Quinn, Helena E. Richardson
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2497-2509 (2017)
In both Drosophila melanogaster and mammalian systems, epithelial structure and underlying cell polarity are essential for proper tissue morphogenesis and organ growth. Cell polarity interfaces with multiple cellular processes that are regulated by t
Externí odkaz:
https://doaj.org/article/95093d56a0a5460d9e89c05e5d5747d9
Autor:
Nicholas R. Lim, Belal Shohayeb, Olga Zaytseva, Naomi Mitchell, S. Sean Millard, Dominic C.H. Ng, Leonie M. Quinn
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 32-41 (2017)
The second most commonly mutated gene in primary microcephaly (MCPH) patients is wd40-repeat protein 62 (wdr62), but the relative contribution of WDR62 function to the growth of major brain lineages is unknown. Here, we use Drosophila models to disse
Externí odkaz:
https://doaj.org/article/7fa5518e5b1442dea2c96eabdf243eb7
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7742 (2020)
The MYC family of transcriptional regulators play significant roles in animal development, including the renewal and maintenance of stem cells. Not surprisingly, given MYC’s capacity to promote programs of proliferative cell growth, MYC is frequent
Externí odkaz:
https://doaj.org/article/b9e0f94d45734b11b091cf553ec53145
Publikováno v:
AIMS Genetics, Vol 1, Iss 1, Pp 81-98 (2014)
Progress in our understanding of the complex signaling events driving human cancer would have been unimaginably slow without discoveries from Drosophila genetic studies. Significantly, many of the signaling pathways now synonymous with cancer biology
Externí odkaz:
https://doaj.org/article/4f447846e41540f8bc0c3f8674315535
Publikováno v:
Cells, Vol 1, Iss 4, Pp 1182-1196 (2012)
Animal growth requires coordination of cell growth and cell cycle progression with developmental signaling. Loss of cell cycle control is extremely detrimental, with reduced cycles leading to impaired organ growth and excessive proliferation, potenti
Externí odkaz:
https://doaj.org/article/86fb75993ec34b0190614e6e3345498a
Autor:
Olga Zaytseva, Naomi C. Mitchell, Damien Muckle, Caroline Delandre, Zuqin Nie, Janis K. Werner, John T. Lis, Eduardo Eyras, Ross D. Hannan, David L. Levens, Owen J. Marshall, Leonie M. Quinn
Publikováno v:
Development. 150
The first characterised FUSE Binding Protein family member, FUBP1, binds single-stranded DNA to activate MYC transcription. Psi, the sole FUBP protein in Drosophila, binds RNA to regulate P-element and mRNA splicing. Our previous work revealed pro-gr
Autor:
Fengwei Yu, Nicole A Siddall, Mai Tran, Yu Cai, Hongyan Wang, Leonie M. Quinn, Nicole Dominado, John E. La Marca, W. Gregory Somers, James Heaney, Gary R. Hime
Publikováno v:
Stem Cell Reports
Summary The Drosophila testis has been fundamental to understanding how stem cells interact with their endogenous microenvironment, or niche, to control organ growth in vivo. Here, we report the identification of two independent alleles for the highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a2cd08b982b28762a42fcb31640fa1
Autor:
Helena E. Richardson, Peter Burke, Leonie M. Quinn, Kasun Amaratunga, Linda M. Parsons, Nicola A. Grzeschik
Publikováno v:
G3 : Genes, Genomes, Genetics, 7(8), 2497-2509. GENETICS SOCIETY AMERICA
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2497-2509 (2017)
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2497-2509 (2017)
In both Drosophila melanogaster and mammalian systems, epithelial structure and underlying cell polarity are essential for proper tissue morphogenesis and organ growth. Cell polarity interfaces with multiple cellular processes that are regulated by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fb71f4df8e12c32eedae86287716e2
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7742, p 7742 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The MYC family of transcriptional regulators play significant roles in animal development, including the renewal and maintenance of stem cells. Not surprisingly, given MYC’s capacity to promote programs of proliferative cell growth, MYC is frequent