An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration

Autor: Agalya Periasamy, Naomi Mitchell, Olga Zaytseva, Arjun S. Chahal, Jiamin Zhao, Peter M. Colman, Leonie M. Quinn, Jacqueline M. Gulbis

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Intronic polymorphic TOMM40 variants increasing TOMM40 mRNA expression are strongly correlated to late onset Alzheimer’s Disease. The gene product, hTomm40, encoded in the APOE gene cluster, is a core component of TOM, the translocase that

Externí odkaz: https://doaj.org/article/152d29d679174b4dbdb60b58aa7f1c2c

Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth

Autor: Nicholas R. Lim, Belal Shohayeb, Olga Zaytseva, Naomi Mitchell, S. Sean Millard, Dominic C.H. Ng, Leonie M. Quinn

Publikováno v: Stem Cell Reports, Vol 9, Iss 1, Pp 32-41 (2017)

The second most commonly mutated gene in primary microcephaly (MCPH) patients is wd40-repeat protein 62 (wdr62), but the relative contribution of WDR62 function to the growth of major brain lineages is unknown. Here, we use Drosophila models to disse

Externí odkaz: https://doaj.org/article/7fa5518e5b1442dea2c96eabdf243eb7

Rbf Regulates Drosophila Spermatogenesis via Control of Somatic Stem and Progenitor Cell Fate in the Larval Testis

Autor: Fengwei Yu, Nicole A Siddall, Mai Tran, Yu Cai, Hongyan Wang, Leonie M. Quinn, Nicole Dominado, John E. La Marca, W. Gregory Somers, James Heaney, Gary R. Hime

Publikováno v: Stem Cell Reports

Summary The Drosophila testis has been fundamental to understanding how stem cells interact with their endogenous microenvironment, or niche, to control organ growth in vivo. Here, we report the identification of two independent alleles for the highl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a2cd08b982b28762a42fcb31640fa1

MYC function and regulation in flies: how Drosophila has enlightened MYC cancer biology

Autor: Jue Er Amanda Lee, Linda May Parsons, Leonie M. Quinn

Publikováno v: AIMS Genetics, Vol 1, Iss 1, Pp 81-98 (2014)

Progress in our understanding of the complex signaling events driving human cancer would have been unimaginably slow without discoveries from Drosophila genetic studies. Significantly, many of the signaling pathways now synonymous with cancer biology

Externí odkaz: https://doaj.org/article/4f447846e41540f8bc0c3f8674315535

A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and CrB Cell Polarity Genes in Epithelial Tissues

Autor: Helena E. Richardson, Peter Burke, Leonie M. Quinn, Kasun Amaratunga, Linda M. Parsons, Nicola A. Grzeschik

Publikováno v: G3 : Genes, Genomes, Genetics, 7(8), 2497-2509. GENETICS SOCIETY AMERICA
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2497-2509 (2017)

In both Drosophila melanogaster and mammalian systems, epithelial structure and underlying cell polarity are essential for proper tissue morphogenesis and organ growth. Cell polarity interfaces with multiple cellular processes that are regulated by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fb71f4df8e12c32eedae86287716e2