Cefepime neurotoxicity: thresholds and risk factors. A Retrospective Cohort study

Autor: Léna Boschung-Pasquier, Philipp Jent, Baharak Babouee Flury, Christoph Hauser, Hansjakob Furrer, Sarah Banholzer, Yok-Ai Que, Andrew Atkinson, Dominique I. Furrer, Manuel Haschke, Leonie Kassandra Kastner, Niccolò Buetti

Publikováno v: Boschung-Pasquier, Léna; Atkinson, Andrew; Kastner, Leonie Kassandra; Banholzer, Sarah; Haschke, Manuel; Buetti, Niccolò; Furrer, Dominique I; Hauser, Christoph; Jent, Philipp; Que, Yok-Ai; Furrer, Hansjakob; Babouee Flury, Baharak (2020). Cefepime neurotoxicity: thresholds and risk factors. A Retrospective Cohort study. Clinical microbiology and infection, 26(3), pp. 333-339. Elsevier 10.1016/j.cmi.2019.06.028

OBJECTIVES Toxic serum cefepime trough concentrations are not well defined in the current literature. We aimed to define a more precise plasma trough concentration threshold for this antibiotic's neurological toxicity and to identify patients at risk

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