Supplementary Figures from Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

Autor: Adam J. Bass, Channing J. Der, Douglas R. Lowy, Adrienne D. Cox, Emanuel F. Petricoin, Kwok-Kin Wong, George Church, Timothy C. Wang, Katherine A. Hoadley, Mariaelena Pierobon, Sarah Derks, Leonie K. de Klerk, Fahire G. Akarca, Zhong Wu, Jin Zhou, Jennifer Liao, Matthew D. Stachler, Alex G. Papageorge, J. Nathaniel Diehl, Devon R. Blake, Richard G. Hodge, Yichen Wang, Antje Schaefer, Haisheng Zhang

Supplementary Figures and Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e810e7c390d32bad4be2d052c43dbf2
https://doi.org/10.1158/2159-8290.22535581.v1

Supplementary Methods from Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

Autor: Adam J. Bass, Channing J. Der, Douglas R. Lowy, Adrienne D. Cox, Emanuel F. Petricoin, Kwok-Kin Wong, George Church, Timothy C. Wang, Katherine A. Hoadley, Mariaelena Pierobon, Sarah Derks, Leonie K. de Klerk, Fahire G. Akarca, Zhong Wu, Jin Zhou, Jennifer Liao, Matthew D. Stachler, Alex G. Papageorge, J. Nathaniel Diehl, Devon R. Blake, Richard G. Hodge, Yichen Wang, Antje Schaefer, Haisheng Zhang

Supplementary Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cf2b19817995da9a9a75ad73aa191b
https://doi.org/10.1158/2159-8290.22535578

Supplementary Video S2 from Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

Autor: Adam J. Bass, Channing J. Der, Douglas R. Lowy, Adrienne D. Cox, Emanuel F. Petricoin, Kwok-Kin Wong, George Church, Timothy C. Wang, Katherine A. Hoadley, Mariaelena Pierobon, Sarah Derks, Leonie K. de Klerk, Fahire G. Akarca, Zhong Wu, Jin Zhou, Jennifer Liao, Matthew D. Stachler, Alex G. Papageorge, J. Nathaniel Diehl, Devon R. Blake, Richard G. Hodge, Yichen Wang, Antje Schaefer, Haisheng Zhang

Supplementary Video S2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593f9baaa0b2cdf971f6b99af39b1142
https://doi.org/10.1158/2159-8290.22535554.v1

Phase II study of pembrolizumab in refractory esophageal cancer with correlates of response and survival

Autor: Eirini Pectasides, Sarah Derks, Charles S. Fuchs, Megan E. Cavanaugh, Peter C. Enzinger, Anuj K. Patel, Amanda J. Rode, Douglas A. Rubinson, Adam J. Bass, Bridget Fitzpatrick, Lauren K. Brais, Nadine Jackson McCleary, Mariano Severgnini, Patrick H. Lizotte, Fahire G Akarca, Jeffrey W. Clark, Leonie K. de Klerk, Melissa G Jean, Matthew Nazzaro, Jeremy Augustin, Mohamed Uduman, James M. Cleary, Hui Zheng, Nihal Raman

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Journal for Immunotherapy of Cancer, 9(9):e002472. BioMed Central
de Klerk, L K, Patel, A K, Derks, S, Pectasides, E, Augustin, J, Uduman, M, Raman, N, Akarca, F G, McCleary, N J, Cleary, J M, Rubinson, D A, Clark, J W, Fitzpatrick, B, Brais, L K, Cavanaugh, M E, Rode, A J, Jean, M G, Lizotte, P H, Nazzaro, M J, Severgnini, M, Zheng, H, Fuchs, C S, Enzinger, P C & Bass, A J 2021, ' Phase II study of pembrolizumab in refractory esophageal cancer with correlates of response and survival ', Journal for Immunotherapy of Cancer, vol. 9, no. 9, e002472 . https://doi.org/10.1136/jitc-2021-002472, https://doi.org/10.1136/jitc-2021-002472
Journal for Immunotherapy of Cancer

BackgroundImmune checkpoint inhibitors have revolutionized cancer treatment, but the benefits in refractory patients with esophageal cancer have been modest. Predictors of response as well as new targets for novel therapeutic combinations are needed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c810cbc651fe7a89668ba3764f6711a
https://jitc.bmj.com/content/9/9/e002472.full

Molecular profiles of response to neoadjuvant chemoradiotherapy in oesophageal cancers to develop personalized treatment strategies

Autor: Henk M.W. Verheul, Nicole C.T. van Grieken, Rosa T. van der Kaaij, Adam J. Bass, Jurriën Stiekema, Victor L. J. L. Thijssen, Leonie K. de Klerk, Donald L. van der Peet, Aaron R. Thorner, Roy L. J. van Wanrooij, Manon van Engeland, Sarah Derks, Arantza Farina Sarasqueta, Johanna W. van Sandick, Maarten A. J. M. Jacobs, Ruben S. A. Goedegebuure, Annemieke Cats

Publikováno v: Molecular Oncology, 15, 901-914
Molecular oncology, 15(4), 901-914. Elsevier
de Klerk, L K, Goedegebuure, R S A, van Grieken, N C T, van Sandick, J W, Cats, A, Stiekema, J, van der Kaaij, R T, Farina Sarasqueta, A, van Engeland, M, Jacobs, M A J M, van Wanrooij, R L J, van der Peet, D L, Thorner, A R, Verheul, H M W, Thijssen, V L J L, Bass, A J & Derks, S 2021, ' Molecular profiles of response to neoadjuvant chemoradiotherapy in oesophageal cancers to develop personalized treatment strategies ', Molecular oncology, vol. 15, no. 4, pp. 901-914 . https://doi.org/10.1002/1878-0261.12907
Molecular Oncology
Molecular Oncology, 15, 4, pp. 901-914
Molecular Oncology, Vol 15, Iss 4, Pp 901-914 (2021)

Identification of molecular predictive markers of response to neoadjuvant chemoradiation could aid clinical decision‐making in patients with localized oesophageal cancer. Therefore, we subjected pretreatment biopsies of 75 adenocarcinoma (OAC) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb63e49f4f3e9c7269a4fea9d4bf26fc
http://hdl.handle.net/2066/235461