Product development programs for neglected tropical diseases: A crucial role for expert meetings.

Autor: Leonie Hussaarts, Kim van der Weijde, Pierre Dome, Elly Kourany-Lefoll, Jutta Reinhard-Rupp, Remco de Vrueh, Pediatric Praziquantel Consortium

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005183 (2017)

Externí odkaz: https://doaj.org/article/47ad14c1049145e2976f5a60e234b3d0

Soluble mannose receptor induces pro-inflammatory macrophage activation and metaflammation

Autor: Laura Schlautmann, Noemí García-Tardón, Bart Everts, Karin de Ruiter, Hendrik J. P. van der Zande, Lisa R. Hoving, Kristian Händler, Ko Willems van Dijk, Isabel Stoetzel, Anna Zawistowska-Deniziak, Bruno Guigas, Joachim L. Schultze, Hanno Pijl, Maria Embgenbroich, Vanessa van Harmelen, Leonard R. Pelgrom, Marjolein A. Wijngaarden, Jonas Schulte-Schrepping, Leonie Hussaarts, Sven Burgdorf, Maria Yazdanbakhsh, Joost M. Lambooij

Pro-inflammatory activation of macrophages in metabolic tissues is critically important in induction of obesity-induced metaflammation. Here, we demonstrate that the soluble mannose receptor (sMR) plays a direct, functional role in both macrophage ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbb08cd5cc6ad47b8e8f6ed951ff0e03
https://doi.org/10.1101/2020.09.29.315598

Human Dendritic Cells with Th2-Polarizing Capacity: Analysis Using Label-Free Quantitative Proteomics

Autor: Arzu Tugce Guler, Maria M. M. Kaisar, Magnus Palmblad, Maria Yazdanbakhsh, Hans Dalebout, Leonie Hussaarts, André M. Deelder, Bart Everts

Publikováno v: International Archives of Allergy and Immunology, 174(3-4), 170-182

Background: Dendritic cells (DCs) are the sentinels of the immune system. Upon recognition of a pathogen, they mature and migrate to draining lymph nodes to prime and polarize T cell responses. Although it is known that helminths and helminth-derived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492b8a4aa37dc44e4b5cae395e2f6d25
https://hdl.handle.net/1887/115693

Vitrification of Tokuyasu-style immuno-labelled sections for correlative cryo light microscopy and cryo electron tomography

Autor: Mark H. Ellisman, Jan R.T. van Weering, Leonie Hussaarts, Heidi de Wit, Erik Bos, Abraham J. Koster

Publikováno v: Journal of Structural Biology, 186(2), 273-282. Academic Press Inc.
Journal of Structural Biology, 186(2), 273-282
Bos, E, Hussaarts, L, van Weering, J R T, Ellisman, M H, de Wit, H & Koster, A J 2014, ' Vitrification of Tokuyasu-style immuno-labelled sections for correlative cryo light microscopy and cryo electron tomography ', Journal of Structural Biology, vol. 186, no. 2, pp. 273-282 . https://doi.org/10.1016/j.jsb.2014.03.021

We present an approach for the preparation of immuno-labelled ultrathin sections from cells or tissue that are compatible with both fluorescence and transmission electron microscopy. Our approach is inspired by a method of Sabanay et al. (1991) that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5d1cc2f3bfb7f9396738e8082b1ff4
https://doi.org/10.1016/j.jsb.2014.03.021

Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice

Autor: Arifa Ozir-Fazalalikhan, Ko Willems van Dijk, Gerard C.M. van der Zon, Jimmy F.P. Berbée, Bruno Guigas, Lianne van Beek, Leonie Hussaarts, Vanessa van Harmelen, Noemí García-Tardón, Simone Haeberlein, Mattijs M. Heemskerk, Maria Yazdanbakhsh

Publikováno v: FASEB Journal, 29(7), 3027-3039

Chronic low-grade inflammation associated with obesity contributes to insulin resistance and type 2 diabetes. Helminth parasites are the strongest natural inducers of type 2 immune responses, and short-lived infection with rodent nematodes was report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2a9f8de7e3b44dd929d043a10a4824
https://pubmed.ncbi.nlm.nih.gov/25917360