Výsledky vyhledávání - "Leonie Hoffmeister"

Akademický článek

Natural antibodies and CRP drive anaphylatoxin production by urate crystals

Autor: Anne Kathrin Wessig, Leonie Hoffmeister, Annika Klingberg, Anika Alberts, Andreas Pich, Korbinian Brand, Torsten Witte, Konstantin Neumann

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract In gout, crystallization of uric acid in the form of monosodium urate (MSU) leads to a painful inflammatory response. MSU crystals induce inflammation by activating the complement system and various immune cell types, and by inducing necroti

Externí odkaz: https://doaj.org/article/fc215984b77e49c793190607bdf5f93a

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Akademický článek

MARCKS Is an Essential Regulator of Reactive Oxygen Species Production in the Monocytic Cell Type

Autor: René Huber, Mareike Diekmann, Leonie Hoffmeister, Friederike Kühl, Bastian Welz, Korbinian Brand

Publikováno v: Antioxidants, Vol 11, Iss 8, p 1600 (2022)

Myristoylated alanine-rich C-kinase substrate (MARCKS) is a ubiquitous protein mediating versatile effects in a variety of cell types, including actin crosslinking, signal transduction, and intracellular transport processes. MARCKS’s functional rol

Externí odkaz: https://doaj.org/article/ce2dcfe229124a43b877837e5dd85955

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Akademický článek

Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures

Autor: Anika Alberts, Annika Klingberg, Leonie Hoffmeister, Anne Kathrin Wessig, Korbinian Brand, Andreas Pich, Konstantin Neumann

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Endogenous and exogenous crystalline structures are involved in various pathologies and diseases in humans by inducing sterile inflammation, mechanical stress, or obstruction of excretory organs. The best studied of these diseases is gout, in which c

Externí odkaz: https://doaj.org/article/763faf98e2e94a47b14619b416aead47

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Akademický článek

GSK3: A Kinase Balancing Promotion and Resolution of Inflammation

Autor: Leonie Hoffmeister, Mareike Diekmann, Korbinian Brand, René Huber

Publikováno v: Cells, Vol 9, Iss 4, p 820 (2020)

GSK3 has been implicated for years in the regulation of inflammation and addressed in a plethora of scientific reports using a variety of experimental (disease) models and approaches. However, the specific role of GSK3 in the inflammatory process is

Externí odkaz: https://doaj.org/article/8603de1981774fe781fd65a206956892

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Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma

Publikováno v: Clinical Cancer Research. :OF1-OF14

Purpose: Interactions with tumor-associated microglia and macrophages (TAM) are critical for glioblastoma progression. Polysialic acid (polySia) is a tumor-associated glycan, but its frequency of occurrence and its prognostic value in glioblastoma ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41f499e7ec0f62317036333b2bcd7aab
https://doi.org/10.1158/1078-0432.ccr-22-1488

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Data from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma

Purpose:Interactions with tumor-associated microglia and macrophages (TAM) are critical for glioblastoma progression. Polysialic acid (polySia) is a tumor-associated glycan, but its frequency of occurrence and its prognostic value in glioblastoma are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a89a453387561fa27a8adeb814abb1
https://doi.org/10.1158/1078-0432.c.6628579.v1

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Supplementary Figure S4 from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma

PolySia on GB tumor cells is associated with NCAM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b5464b6d5d33fbe99fbe6acad6c41c
https://doi.org/10.1158/1078-0432.22746412.v1

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Supplementary Methods S1 from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma

Supplementary Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093da10b055adbaadf16991d6c6cf69c
https://doi.org/10.1158/1078-0432.22746403.v1

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Supplementary Tables S1-S14 from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma

Supplementary Table S1.Demographic and clinical parameters of GB patient cohorts.Supplementary Table S2.Characteristics of the two cohorts of n = 70 (MHH) and n = 100 (UMG) GB patients stratified for the presence of a functional SIGLEC16 allele (A) o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bcf3896a6f6e04551d1064d65aa3c8c
https://doi.org/10.1158/1078-0432.22746397

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Activation of GSK3 Prevents Termination of TNF-Induced Signaling

Autor: Korbinian Brand, Mareike Diekmann, Leonie Hoffmeister, Rolf Bikker, Martin Christmann, René Huber, Bastian Welz

Publikováno v: Journal of Inflammation Research

Bastian Welz,* Rolf Bikker,* Leonie Hoffmeister, Mareike Diekmann, Martin Christmann, Korbinian Brand,* René Huber* Institute of Clinical Chemistry, Hannover Medical School, Hannover, 30625, Germany*These authors contributed equally to this workCorr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a619ebb5727e94e848188bb31fb255
https://doi.org/10.2147/jir.s300806

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