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pro vyhledávání: '"Leonie Heyden"'
Autor:
Patrick M. Gubser, Sharanya Wijesinghe, Leonie Heyden, Sarah S. Gabriel, David P. de Souza, Christoph Hess, Malcolm M. McConville, Daniel T. Utzschneider, Axel Kallies
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114632- (2024)
Summary: Tumor cells undergo uncontrolled proliferation driven by enhanced anabolic metabolism including glycolysis and glutaminolysis. Targeting these pathways to inhibit cancer growth is a strategy for cancer treatment. Critically, however, tumor-r
Externí odkaz:
https://doaj.org/article/ed496fbd2a8c447f9858e95fb3791214
Autor:
Jonas Lategahn, Hannah L. Tumbrink, Carsten Schultz-Fademrecht, Alena Heimsoeth, Lisa Werr, Janina Niggenaber, Marina Keul, Fatma Parmaksiz, Matthias Baumann, Sascha Menninger, Eldar Zent, Ina Landel, Jörn Weisner, Kirujan Jeyakumar, Leonie Heyden, Nicole Russ, Fabienne Müller, Carina Lorenz, Johannes Brägelmann, Inga Spille, Tobias Grabe, Matthias P. Müller, Johannes M. Heuckmann, Bert M. Klebl, Peter Nussbaumer, Martin L. Sos, Daniel Rauh
Publikováno v:
Journal of Medicinal Chemistry. 65:6643-6655
Despite the clinical efficacy of epidermal growth factor receptor (EGFR) inhibitors, a subset of patients with non-small cell lung cancer displays insertion mutations in exon20 in EGFR and Her2 with limited treatment options. Here, we present the dev
Autor:
Daniel Rauh, Matthias P. Müller, Jonas Lategahn, Tobias Grabe, Janina Niggenaber, Leonie Heyden
Publikováno v:
ACS Med Chem Lett
[Image: see text] Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) and currently the gold-standard for the treatment of patients suffering from non-small cell lung cancer (NSCLC) harboring T790M-mutated epidermal growth factor recept