Hypoxia Abrogates Tumor-Suppressive Activities of C/EBPδ in Pancreatic Cancer

Autor: Leonie Hartl, Marieke S. ten Brink, Hella L. Aberson, Jan Koster, Danny A. Zwijnenburg, JanWillem Duitman, Maarten F. Bijlsma, C. Arnold Spek

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 17, p 9449 (2024)

Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a low 5-year survival rate of only 13%. Despite intense research efforts, PDAC remains insufficiently understood. In part, this is attributed to opposing effects of key players being un

Externí odkaz: https://doaj.org/article/c3b6f80a508d47debd1643a94dbe33ab

C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC

Autor: Leonie Hartl, Joris J. T. H. Roelofs, Frederike Dijk, Maarten F. Bijlsma, JanWillem Duitman, C. Arnold Spek

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 2, p 1537 (2023)

Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a poor clinical prognosis and unsatisfactory treatment options. We previously found that the transcription factor CCAAT/Enhancer-Binding Protein Delta (C/EBPδ) is lowly expressed in PD

Externí odkaz: https://doaj.org/article/fb34ce85fd9541798e7888cb6e5de024

Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation

Autor: JanWillem Duitman, Leonie Hartl, Joris J. T. H. Roelofs, Maarten F. Bijlsma, C. Arnold Spek

Publikováno v: Biomolecules, Vol 11, Iss 8, p 1079 (2021)

CCAAT/enhancer-binding protein delta (C/EBPδ) is a transcription factor involved in apoptosis and proliferation, which is downregulated in pancreatic ductal adenocarcinoma (PDAC) cells. Loss of nuclear C/EBPδ in PDAC cells is associated with decrea

Externí odkaz: https://doaj.org/article/fbc593a762624215b2689b7d8cd45af3

Ccaat/enhancer-binding protein delta (C/ebpδ): A previously unrecognized tumor suppressor that limits the oncogenic potential of pancreatic ductal adenocarcinoma cells

Autor: Maikel P. Peppelenbosch, Kan Chen, Gerrit K. J. Hooijer, Leonie Hartl, Joris J. T. H. Roelofs, C. Arnold Spek, Hella L. Aberson, JanWillem Duitman, Pratika Y. Hernanda, Ton Boerman, Mark P. G. Dings, Olivier R. Busch, Marc G. Besselink, Frederike Dijk, Maarten F. Bijlsma, Qiunwei Pan

Publikováno v: Cancers, 12(9):2546, 1-21. Multidisciplinary Digital Publishing Institute (MDPI)
Hartl, L, Duitman, J, Aberson, H L, Chen, K, Dijk, F, Roelofs, J J T H, Dings, M P G, Hooijer, G K J, Hernanda, P Y, Pan, Q, Busch, O R, Besselink, M G H, Boerman, T, Peppelenbosch, M P, Bijlsma, M F & Spek, C A 2020, ' Ccaat/enhancer-binding protein delta (C/ebpδ) : A previously unrecognized tumor suppressor that limits the oncogenic potential of pancreatic ductal adenocarcinoma cells ', Cancers, vol. 12, no. 9, 2546, pp. 1-21 . https://doi.org/10.3390/cancers12092546
Cancers, Vol 12, Iss 2546, p 2546 (2020)
Cancers
Volume 12
Issue 9

CCAAT/enhancer-binding protein &delta
(C/EBP&delta
) is a transcription factor involved in growth arrest and differentiation, which has consequently been suggested to harbor tumor suppressive activities. However, C/EBP&delta
over-expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcbf74028076458d10282193c980be5
https://pure.amc.nl/en/publications/ccaatenhancerbinding-protein-delta-cebp-a-previously-unrecognized-tumor-suppressor-that-limits-the-oncogenic-potential-of-pancreatic-ductal-adenocarcinoma-cells(2f283c0e-a342-4377-9e15-5dbfefda0a35).html

Yamanaka factors and iPS cells

Autor: Stina Simonsson, Itedale N. Redwan, Rocío C. Viñuelas, Joydeep Bhadury, Leonie Hartl

Cells from elderly individuals can by scientists be reprogrammed back to totipotent or pluripotent cells. The first method that achieved reprogramming to totipotency (and thereby pluripotency) was cloning of animals, for example, creation of cloned f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99895c5128841a55abb81808002985a3
https://doi.org/10.1016/b978-0-12-801238-3.65252-2