C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration

Autor: Leonie Hartl, Pien A. F. Maarschalkerweerd, Joe M. Butler, Xue D. Manz, Victor L. J. L. Thijssen, Maarten F. Bijlsma, JanWillem Duitman, C. Arnold Spek

Publikováno v: Cells, Vol 11, Iss 21, p 3334 (2022)

Pancreatic Ductal Adenocarcinoma (PDAC) is among the most aggressive human cancers and occurs globally at an increasing incidence. Metastases are the primary cause of cancer-related death and, in the majority of cases, PDAC is accompanied by metastat

Externí odkaz: https://doaj.org/article/c40525e5847b4102add33b8dc3094fbd

The dual role of C/EBPδ in cancer

Autor: Leonie Hartl, JanWillem Duitman, Maarten F. Bijlsma, C. Arnold Spek

Publikováno v: Hartl, L, Duitman, J, Bijlsma, M F & Spek, C A 2023, ' The dual role of C/EBPδ in cancer ', Critical Reviews in Oncology/Hematology, vol. 185, 103983 . https://doi.org/10.1016/j.critrevonc.2023.103983

CCAAT/Enhancer-Binding Protein delta (C/EBPδ) is a transcription factor involved in differentiation and inflammation. While sparsely expressed in adult tissues, aberrant expression of C/EBPδ has been associated with different cancers. Initially, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9448a2b90ad871e6961bc19254d3bea
https://research.vumc.nl/en/publications/0597f2f3-8cc0-425d-a002-02d1f2342432

Ccaat/enhancer-binding protein delta (C/ebpδ): A previously unrecognized tumor suppressor that limits the oncogenic potential of pancreatic ductal adenocarcinoma cells

Autor: Maikel P. Peppelenbosch, Kan Chen, Gerrit K. J. Hooijer, Leonie Hartl, Joris J. T. H. Roelofs, C. Arnold Spek, Hella L. Aberson, JanWillem Duitman, Pratika Y. Hernanda, Ton Boerman, Mark P. G. Dings, Olivier R. Busch, Marc G. Besselink, Frederike Dijk, Maarten F. Bijlsma, Qiunwei Pan

Publikováno v: Cancers, 12(9):2546, 1-21. Multidisciplinary Digital Publishing Institute (MDPI)
Hartl, L, Duitman, J, Aberson, H L, Chen, K, Dijk, F, Roelofs, J J T H, Dings, M P G, Hooijer, G K J, Hernanda, P Y, Pan, Q, Busch, O R, Besselink, M G H, Boerman, T, Peppelenbosch, M P, Bijlsma, M F & Spek, C A 2020, ' Ccaat/enhancer-binding protein delta (C/ebpδ) : A previously unrecognized tumor suppressor that limits the oncogenic potential of pancreatic ductal adenocarcinoma cells ', Cancers, vol. 12, no. 9, 2546, pp. 1-21 . https://doi.org/10.3390/cancers12092546
Cancers, Vol 12, Iss 2546, p 2546 (2020)
Cancers
Volume 12
Issue 9

CCAAT/enhancer-binding protein &delta
(C/EBP&delta
) is a transcription factor involved in growth arrest and differentiation, which has consequently been suggested to harbor tumor suppressive activities. However, C/EBP&delta
over-expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcbf74028076458d10282193c980be5
https://pure.amc.nl/en/publications/ccaatenhancerbinding-protein-delta-cebp-a-previously-unrecognized-tumor-suppressor-that-limits-the-oncogenic-potential-of-pancreatic-ductal-adenocarcinoma-cells(2f283c0e-a342-4377-9e15-5dbfefda0a35).html

Yamanaka factors and iPS cells

Autor: Stina Simonsson, Itedale N. Redwan, Rocío C. Viñuelas, Joydeep Bhadury, Leonie Hartl

Cells from elderly individuals can by scientists be reprogrammed back to totipotent or pluripotent cells. The first method that achieved reprogramming to totipotency (and thereby pluripotency) was cloning of animals, for example, creation of cloned f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99895c5128841a55abb81808002985a3
https://doi.org/10.1016/b978-0-12-801238-3.65252-2