Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Leonie Harmse"'
Autor:
Leonie Harmse, Helmuth Reuter
Publikováno v:
South African Family Practice, Vol 58, Iss 6, Pp 6-10 (2016)
The past decade has seen a major change in the treatment options and strategies for rheumatoid arthritis (RA) and the other immune-mediated arthritic diseases. The disease modifying antirheumatic drugs (DMARDs) are now used in early stages of the dis
Externí odkaz:
https://doaj.org/article/1248f4fe9d1e473a9708a3ac6323da8f
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138607 (2015)
Despite the increased understanding of colorectal cancer and the introduction of targeted drug therapy, the metastatic phase of the disease remains refractory to treatment. Since the deregulation of normal apoptosis contributes to the pathogenesis of
Externí odkaz:
https://doaj.org/article/6c7e11db09a945eeb00b35a9b4e2c6e9
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 50(34)
Despite the concerted efforts to develop targeted cancer treatments, these therapies are plagued by the rapid development of resistance and serious adverse drug reactions. Based on the wide clinical use and successes of the platinum drugs like cispla
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1869(1)
Despite the availability of a myriad targeted treatments, resistance and treatment failures remains common in cancer treatment. Moreover, the high cost of targeted antibodies excludes a large cohort of patients from their benefits. In this context, c
Autor:
Tebogo Peega, Leonie Harmse, Izak A. Kotzé, Juanita L. van Wyk, Edmore F. Kangara, Demetrius C. Levendis
Publikováno v:
New Journal of Chemistry. 43:3665-3672
The mixed-ligand [Pt(phen)(L1-κS)2] complex, in which two N,N-diethyl-N′-1-naphthoylthioureato ligands (L1)− coordinate in an unusual κS-thio/amido mode, crystallises in two solvatomorphs, form I and form II, whose structures have been determin
Autor:
Allen T. Gordon, Olufunso O. Abosede, Songeziwe Ntsimango, Eric C. Hosten, Nonzuzo Myeza, Armorel van Eyk, Leonie Harmse, Adeniyi S. Ogunlaja
Publikováno v:
Polyhedron. 214:115649
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO3-7
Publikováno v:
Apoptosis : an international journal on programmed cell death. 24(7-8)
Metastatic colorectal cancer responds poorly to treatment and is a leading cause of cancer related deaths. Worldwide, chemotherapy of metastatic colorectal cancer remains plagued by poor efficacy, development of resistance and serious adverse effects
Autor:
Ivan R. Green, Willem A. L. van Otterlo, M.E. Christine Rey, Stephen C. Pelly, Laetitia Moreno Y Banuls, Leonie Harmse, Helen Apostolellis, Alexander Kornienko, Nurit Dahan-Farkas, Robert Kiss, Hajierah Davids, Jenny-Lee Panayides, Véronique Mathieu
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2716-2724
Seventeen silyl- and trityl-modified (5′-O- and 3′,5′-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a fixe
Autor:
Danielle Aucamp, David C. Liles, Manuel A. Fernandes, Leonie Harmse, Daniela Ina Bezuidenhout, Sreedhar Vellas Kumar
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 47(45)
1,2,3-Triazol-5-ylidene (trz) complexes of gold(i) containing a ferrocenyl substituent on the C4-position of the trz ring were synthesized to yield the neutral heterobimetallic gold(i) trz chlorido (2), gold(i) trz phenyl (3), and the cationic gold(i