Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Leonie H Venema"'
Autor:
Daan J Touw, Henri G D Leuvenink, Rene A Posma, Leonie H Venema, Tobias M Huijink, Andrie C Westerkamp, A Mireille A Wessels, Nynke J De Vries, Frank Doesburg, J Roggeveld, Petra J Ottens, Maarten W Nijsten
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
Introduction Metformin can accumulate and cause lactic acidosis in patients with renal insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by proximal tubules indirectly requires energy. We investigated whethe
Externí odkaz:
https://doaj.org/article/4a418a50738d42c09e6d14cd98373018
Autor:
Hanno Maassen, Koen D W Hendriks, Leonie H Venema, Rob H Henning, Sijbrand H Hofker, Harry van Goor, Henri G D Leuvenink, Annemieke M Coester
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225152 (2019)
BACKGROUND:Since the start of organ transplantation, hypothermia-forced hypometabolism has been the cornerstone in organ preservation. Cold preservation showed to protect against ischemia, although post-transplant injury still occurs and further impr
Externí odkaz:
https://doaj.org/article/8863d7161b8f4c5d83fc783e62e01f8e
Autor:
Leonie van Leeuwen, Leonie H. Venema, Raphael Heilig, Henri G. D. Leuvenink, Benedikt M. Kessler
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 2, Pp 559-577 (2022)
Ischemia-reperfusion injury (IRI) is a hallmark for tissue injury in donation after circulatory death (DCD) kidneys. The implementation of hypothermic machine perfusion (HMP) provides a platform for improved preservation of DCD kidneys. Doxycycline a
Externí odkaz:
https://doaj.org/article/8002f44076ef4bbb9afd41160053021f
Publikováno v:
Transplantology, Vol 3, Iss 1, Pp 6-19 (2021)
Machine perfusion techniques are becoming standard care in the clinical donation and transplantation setting. However, more research is needed to understand the mechanisms of the protective effects of machine perfusion. For preservation related exper
Externí odkaz:
https://doaj.org/article/990ee5de32274539957a37f191660220
Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys
Autor:
Neeltina M. Jager, Leonie H. Venema, Asel S. Arykbaeva, Anita H. Meter-Arkema, Petra J. Ottens, Cees van Kooten, Tom E. Mollnes, Ian P. J. Alwayn, Henri G. D. Leuvenink, Soeren E. Pischke, PROPER study consortium
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThe gap between demand and supply of kidneys for transplantation necessitates the use of kidneys from extended criteria donors. Transplantation of these donor kidneys is associated with inferior results, reflected by an increased risk of de
Externí odkaz:
https://doaj.org/article/c1c57527154445c8add357819d54ed04
Autor:
Aukje Brat, MD, Leonie H. Venema, MSc, Bas W.J. Bens, MD, Remy Stieglis, MSc, Joris J. van der Heijden, MD, Constantino Fondevila, MD, PhD, Oleg N. Reznik, MD, PhD, Benoit Barrou, MD, PhD, Michiel E. Erasmus, MD, PhD, Henri G.D. Leuvenink, PhD
Publikováno v:
Transplantation Direct, Vol 8, Iss 1, p e1263 (2022)
Background. Donation after unexpected circulatory death (uDCD) donors are often suggested to increase the number of donor organs. In 2014, a uDCD protocol was implemented in three transplant centers in the Netherlands which unfortunately did not resu
Externí odkaz:
https://doaj.org/article/89e47d2298ff465897a263959243934c
Autor:
Hanno Maassen, Leonie H. Venema, Marc G. Weiss, Tobias M. Huijink, H. Sijbrand Hofker, Anna K. Keller, Tom E. Mollnes, Marco Eijken, Søren E. Pischke, Bente Jespersen, Harry van Goor, Henri G. D. Leuvenink
Publikováno v:
Antioxidants; Volume 12; Issue 3; Pages: 749
Antioxidants (Basel, Switzerland), 12(3):749. MDPI AG
Maassen, H, Venema, L H, Weiss, M G, Huijink, T M, Hofker, H S, Keller, A K, Mollnes, T E, Eijken, M, Pischke, S E, Jespersen, B, van Goor, H & Leuvenink, H G D 2023, ' H 2 S-Enriched Flush out Does Not Increase Donor Organ Quality in a Porcine Kidney Perfusion Model ', Antioxidants, vol. 12, no. 3, 749 . https://doi.org/10.3390/antiox12030749
Antioxidants (Basel, Switzerland), 12(3):749. MDPI AG
Maassen, H, Venema, L H, Weiss, M G, Huijink, T M, Hofker, H S, Keller, A K, Mollnes, T E, Eijken, M, Pischke, S E, Jespersen, B, van Goor, H & Leuvenink, H G D 2023, ' H 2 S-Enriched Flush out Does Not Increase Donor Organ Quality in a Porcine Kidney Perfusion Model ', Antioxidants, vol. 12, no. 3, 749 . https://doi.org/10.3390/antiox12030749
Kidney extraction time has a detrimental effect on post-transplantation outcome. This study aims to improve the flush-out and potentially decrease ischemic injury by the addition of hydrogen sulphide (H 2S) to the flush medium. Porcine kidneys ( n =
Autor:
Nynke J de Vries, Tobias M Huijink, Petra J. Ottens, Maarten W. N. Nijsten, Henri G. D. Leuvenink, Rene A. Posma, Andrie C. Westerkamp, Daan J Touw, Leonie H Venema
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 222-230 (2021)
Clinical and translational science, 14(1), 222-230. Wiley
Clinical and Translational Science
Clinical and translational science, 14(1), 222-230. Wiley
Clinical and Translational Science
Metformin may act renoprotective prior to kidney transplantation by reducing ischemia-reperfusion injury (IRI). This study examined whether metformin preconditioning and postconditioning duringex vivonormothermic machine perfusion (NMP) of rat and po
Autor:
Aukje Brat, Leonie H. Venema, Bas W.J. Bens, Remy Stieglis, Joris J. van der Heijden, Constantino Fondevila, Oleg N. Reznik, Benoit Barrou, Michiel E. Erasmus, Henri G.D. Leuvenink
Publikováno v:
Transplantation Direct
Transplantation Direct, Vol 8, Iss 1, p e1263 (2022)
Transplantation direct, 8(1):1263. LIPPINCOTT WILLIAMS & WILKINS
Transplantation direct, 8(1):E1263. Wolters Kluwer Health
Transplantation Direct, Vol 8, Iss 1, p e1263 (2022)
Transplantation direct, 8(1):1263. LIPPINCOTT WILLIAMS & WILKINS
Transplantation direct, 8(1):E1263. Wolters Kluwer Health
Background. Donation after unexpected circulatory death (uDCD) donors are often suggested to increase the number of donor organs. In 2014, a uDCD protocol was implemented in three transplant centers in the Netherlands which unfortunately did not resu
Autor:
Koen D. W. Hendriks, Guido Krenning, Henri G. D. Leuvenink, P. Vogelaar, Leonie H Venema, L. Annick van Furth
Publikováno v:
Transplantology
Volume 2
Issue 3
Pages 31-314
Transplantology, 2(3), 304-314. MDPI AG
Transplantology, Vol 2, Iss 31, Pp 304-314 (2021)
Volume 2
Issue 3
Pages 31-314
Transplantology, 2(3), 304-314. MDPI AG
Transplantology, Vol 2, Iss 31, Pp 304-314 (2021)
Diminishing ischemia-reperfusion injury (IRI) by improving kidney preservation techniques offers great beneficial value for kidney transplant recipients. Mitochondria play an important role in the pathogenesis of IRI and are therefore interesting tar