Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leonie Gibson"'
Autor:
Cindy Audiger, Yacine Laâbi, Junli Nie, Leonie Gibson, Julie Wilson-Annan, Phillip Brook-Carter, Andrew Kueh, Alan W. Harris, Shalin Naik, Stephen L. Nutt, Andreas Strasser, Jerry M. Adams, Philippe Bouillet, Michaël Chopin
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114159- (2024)
Summary: The traditional view of hematopoiesis is that myeloid cells derive from a common myeloid progenitor (CMP), whereas all lymphoid cell populations, including B, T, and natural killer (NK) cells and possibly plasmacytoid dendritic cells (pDCs),
Externí odkaz:
https://doaj.org/article/c89909ecc3fe477ea2e87a7d2dff8850
Autor:
Michael A. Dengler, Adeline Y. Robin, Leonie Gibson, Mark X. Li, Jarrod J. Sandow, Sweta Iyer, Andrew I. Webb, Dana Westphal, Grant Dewson, Jerry M. Adams
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 359-373.e6 (2019)
Summary: To elicit apoptosis, BAX metamorphoses from an inert cytosolic monomer into homo-oligomers that permeabilize the mitochondrial outer membrane (MOM). A long-standing puzzle is that BH3 domains apparently activate BAX by not only its canonical
Externí odkaz:
https://doaj.org/article/1a88cb70b3f14443b0f43847941a9243
Autor:
Andreas Strasser, Cindy Audiger, Yacine Laabi, Leonie Gibson, Julie Wilson-Annan, Philipp Brook-Carter, Andrew Kueh, Alan Harris, Shalin Naik, Stephen Nutt, Jerry Adams, Philippe Bouillet, Michael Chopin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81ba2dff82ff9fbbcfc87bba40199d3b
https://doi.org/10.2139/ssrn.4321074
https://doi.org/10.2139/ssrn.4321074
Publikováno v:
Cell Death Differ
The conformational changes converting BAX from an inert cytosolic monomer into the homo-oligomers that permeabilize the mitochondrial outer membrane (MOM) are crucial steps toward apoptosis. Here, we have explored the potential role of the BAX α1-α
Publikováno v:
Cell Death and Differentiation
Drugs targeting various pro-survival BCL-2 family members (''BH3 mimetics'') have efficacy in hemopoietic malignancies, but the non-targeted pro-survival family members can promote resistance. Pertinently, the sensitivity of some tumor cell lines to
Autor:
Jerry M. Adams, Leonie Gibson, Mark Xiang Li, Sweta Iyer, Grant Dewson, D. Westphal, Andrew I. Webb, Michael A. Dengler, Adeline Y. Robin, Jarrod J. Sandow
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 359-373.e6 (2019)
Summary: To elicit apoptosis, BAX metamorphoses from an inert cytosolic monomer into homo-oligomers that permeabilize the mitochondrial outer membrane (MOM). A long-standing puzzle is that BH3 domains apparently activate BAX by not only its canonical
Autor:
Grant Dewson, Brian J. Smith, Leonie Gibson, Paul Frederick, Sweta Iyer, D. Westphal, Marie Menard, Jerry M. Adams, Ray Bartolo, Ruth M. Kluck, Peter E. Czabotar
Publikováno v:
Proceedings of the National Academy of Sciences. 111
The pivotal step on the mitochondrial pathway to apoptosis is permeabilization of the mitochondrial outer membrane (MOM) by oligomers of the B-cell lymphoma-2 (Bcl-2) family members Bak or Bax. However, how they disrupt MOM integrity is unknown. A lo
Promoter Elements of vav Drive Transgene Expression In Vivo Throughout the Hematopoietic Compartment
Publikováno v:
Blood. 94:1855-1863
To develop a method for targeting expression of genes to the full hematopoietic system, we have used transgenic mice to explore the transcriptional regulation of the vav gene, which is expressed throughout this compartment but rarely outside it. Prev
Autor:
Karin M Innes, Jerry M. Adams, Leonie Gibson, Heather E Davidson, Suzanne Cory, Stephen J. Szilvassy
Publikováno v:
Europe PubMed Central
Transduction of hematopoietic stem cells with a novel retrovirus has allowed long-term expression of human Bcl-2 in multiple hematopoietic lineages. Thy-1.2 lo Sca-1 + H-2K hi stem cells enriched from the bone marrow of 5-fluorouracil–treated (Ly5-
Autor:
Donald Metcalf, Anna Stylianou, Nigel G. Wreford, Terry Meehan, Suzanne Cory, Cris G Print, Leonie Gibson, D. M. De Kretser, Frank Köntgen, Jerry M. Adams, Kate L Loveland
Publikováno v:
Monash University
Europe PubMed Central
Europe PubMed Central
Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the embryo and adult. The recently isolatedbcl-wgene encodes a pro-survival member of the Bcl-2 family, which is widely expressed. To explore its physiological role