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pro vyhledávání: '"Leonie Funk"'
Autor:
Marius Kollmer, William Close, Leonie Funk, Jay Rasmussen, Aref Bsoul, Angelika Schierhorn, Matthias Schmidt, Christina J. Sigurdson, Mathias Jucker, Marcus Fändrich
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Alzheimer’s disease is characterised by the deposition of Aβ amyloid fibrils and tau protein neurofibrillary tangles. Here the authors use cryo-EM to structurally characterise brain derived Aβ amyloid fibrils and find that they are polymorphic an
Externí odkaz:
https://doaj.org/article/bd15cbb55e35470c93b5f854aad34b44
Autor:
Jay Rasmussen, Leonie Funk, Marcus Fändrich, Aref Bsoul, Christina J. Sigurdson, Mathias Jucker, Angelika Schierhorn, Marius Kollmer, Matthias Schmidt, William Close
Publikováno v:
Nature Communications
Nature Communications 10(1), 4760 (2019). doi:10.1038/s41467-019-12683-8
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Nature Communications 10(1), 4760 (2019). doi:10.1038/s41467-019-12683-8
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
The formation of Aβ amyloid fibrils is a neuropathological hallmark of Alzheimer’s disease and cerebral amyloid angiopathy. However, the structure of Aβ amyloid fibrils from brain tissue is poorly understood. Here we report the purification of A