Effects of dapagliflozin on postprandial lipid metabolism in type 2 diabetes mellitus

Autor: Benjamin Burggraaf, Nadine M C Pouw, Salvador Fernández Arroyo, Leonie C van Vark-van der Zee, Gert-Jan M van de Geijn, Erwin Birnie, Jeannine Huisbrink, Ellen M van der Zwan, Wouter W de Herder, Monique T Mulder, Patrick C N Rensen, Manuel Castro Cabezas

Publikováno v: European journal of endocrinology, 186(5), 597-605. BIOSCIENTIFICA LTD
European Journal of Endocrinology, 186(5), 597-605. Bioscientifica Ltd
European Journal of Endocrinology, 186(5), 597-605. BIOSCIENTIFICA LTD

Objectives Sodium-glucose cotransporter 2 inhibitors (SGLT2i) modulate lipid metabolism and improve cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). The exact cardioprotective mechanism of SGLT2i is unclear. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1424477cd856305f77b9871e9de0fc9e
https://doi.org/10.1530/eje-21-1270

A placebo-controlled proof-of-concept study of alirocumab on postprandial lipids and vascular elasticity in insulin-treated patients with type 2 diabetes mellitus

Autor: Jeannine Huisbrink, Manuel Castro Cabezas, Monique T. Mulder, Nadine Pouw, Gert-Jan M. van de Geijn, Benjamin Burggraaf, Leonie C. van Vark-van der Zee, Patrick C.N. Rensen, Ellen van der Zwan, Wouter W. de Herder, Salvador Fernandez Arroyo, Erwin Birnie

Publikováno v: Diabetes obesity & metabolism, 22(5), 807-816. Wiley
Diabetes, Obesity and Metabolism, 22(5), 807-816. Wiley-Blackwell Publishing Ltd
Diabetes, Obesity and Metabolism, 22(5), 807-816. WILEY

AIM: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular disease (CVD) linked to atherogenic dyslipidaemia and postprandial hyperlipidaemia. Alirocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda152640ae291fef69e6bdcb34f9c1e
https://hdl.handle.net/11370/198197d2-8ddc-40ef-b282-e717e759b5f3

A mouse model of humanized liver shows a human-like lipid profile, but does not form atherosclerotic plaque after western type diet

Autor: Andre Boonstra, Maikel P. Peppelenbosch, Jeanine E. Roeters van Lennep, Gulce Sari, Kim van der Heiden, Leonie C. van Vark-van der Zee, Kristiaan Wouters, Monique T. Mulder, Thomas Vanwolleghem, Eric Jan Meester

Publikováno v: Biochemical and Biophysical Research Communications, 524, 510-515. Academic Press
Biochemical and Biophysical Research Communications, 524(2), 510-515. Elsevier
Biochemical and biophysical research communications

Mouse models are a crucial and often used tool to provide insight into the underlying mechanisms of human atherosclerosis. However, mice profoundly differ from humans in lipoprotein synthesis and metabolism, key factors in atherosclerotic plaque form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997ea71ff3747491c212c2c9c86b9fa7
https://pure.eur.nl/en/publications/9c8b51c8-4b65-40d4-bbd2-3c2a1f4c3db0

Variation in Coronary Atherosclerosis Severity Related to a Distinct LDL (Low-Density Lipoprotein) Profile: Findings From a Familial Hypercholesterolemia Pig Model

Autor: Ludovic Drouet, Jurgen Ligthart, Ayla Hoogendoorn, Monique T. Mulder, Maaike te Lintel Hekkert, Jolanda J. Wentzel, Kristien Dorst, Kim Van der Heiden, Eline M J Hartman, Dirk J. Duncker, Kim van Gaalen, Jeanine E. Roeters van Lennep, Sandra den Hoedt, Leonie C. van Vark-van der Zee, Ilona Krabbendam-Peters, Antonius F.W. van der Steen, Karen Witberg

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis Thrombosis & Vascular Biology, 39(11), 2338-2352. Lippincott Williams & Wilkins

Supplemental Digital Content is available in the text.
Objective: In an adult porcine model of familial hypercholesterolemia (FH), coronary plaque development was characterized. To elucidate the underlying mechanisms of the observed inter-indivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de853b5f6c2f5c8906bff5bb1eb4d457
https://pubmed.ncbi.nlm.nih.gov/31644349

Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach

Autor: Anho H Liem, Albert Hofman, Adriana C. Blommesteijn-Touw, Iris Kindt, Jeanette Erdman, Mojgan Yazdanpanah, Fátima Almagro, Frans van der Ouderaa, Ranitha Vongpromek, Fernando Civeira, Jose M. Ordovas, Peter W. de Leeuw, Keith J. Johnson, Hrobjartur D. Karlsson, Monique T. Mulder, Daniëlla M. Oosterveer, Tony Dadd, Martin R. Green, Joep C. Defesche, Roeland Huijgen, Abbas Dehghan, Maarten L. Simoons, Hilma Holm, Leonie C. van Vark-van der Zee, Leiv Ose, Aeilko H. Zwinderman, Cornelia M. van Duijn, Gisle Langslet, Luis Masana, Maurizio Averna, Gudmar Thorleifsson, Jorie Versmissen, A F L Schinkel, Jaap Kwekkeboom, Yurii S. Aulchenko, Jacqueline C. M. Witteman, John J.P. Kastelein, Heribert Schunkert, Steve E. Humphries, Arne S. Schaefer, Stefano Bertolini, Emilio Ros, Xavier Pintó, Andrew Neil, André G. Uitterlinden, Eric J.G. Sijbrands, Amelia Jarman, Sebastiano Calandra

Publikováno v: European journal of human genetics, 23(3), 381-387. Nature Publishing Group
European Journal of Human Genetics, 23(3), 381-387. Nature Publishing Group
European Journal of Human Genetics, 23(3), 381-387

Mutations in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolemia (FH), a disorder characterized by coronary heart disease (CHD) at young age. We aimed to apply an extreme sampling method to enhance the statistical pow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b4bf108a24c38e57156f1d8016f15a
https://doi.org/10.1038/ejhg.2014.101