Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Leonie, Voorwerk"'
Autor:
Leonie Voorwerk, Joyce Sanders, Milou S. Keusters, Sara Balduzzi, Sten Cornelissen, Maxime Duijst, Esther H. Lips, Gabe S. Sonke, Sabine C. Linn, Hugo M. Horlings, Marleen Kok
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Immune checkpoint blockade (ICB) is currently approved for patients with triple-negative breast cancer (TNBC), whereas responses to ICB are also observed in a small subgroup of Estrogen Receptor (ER)-positive breast cancer. The cut-off for E
Externí odkaz:
https://doaj.org/article/bf1f76273f634aa69a34a1e2029a1773
Autor:
Dora Hammerl, John W. M. Martens, Mieke Timmermans, Marcel Smid, Anita M. Trapman-Jansen, Renée Foekens, Olga I. Isaeva, Leonie Voorwerk, Hayri E. Balcioglu, Rebecca Wijers, Iris Nederlof, Roberto Salgado, Hugo Horlings, Marleen Kok, Reno Debets
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Only a subset of triple negative breast cancer patients respond to immunotherapy. Here, the authors analysed spatial immune contextures, which can be captured by a gene classifier, in relation to genomic alterations, mechanisms of T cell evasion and
Externí odkaz:
https://doaj.org/article/c987387dc5c94a1b93ac3cb4c523d2fd
Autor:
Leonie Voorwerk, Olga I. Isaeva, Hugo M. Horlings, Sara Balduzzi, Maksim Chelushkin, Noor A. M. Bakker, Elisa Champanhet, Hannah Garner, Karolina Sikorska, Claudette E. Loo, Inge Kemper, Ingrid A. M. Mandjes, Michiel de Maaker, Jasper J. L. van Geel, Jorianne Boers, Maaike de Boer, Roberto Salgado, Marloes G. J. van Dongen, Gabe S. Sonke, Karin E. de Visser, Ton N. Schumacher, Christian U. Blank, Lodewyk F. A. Wessels, Agnes Jager, Vivianne C. G. Tjan-Heijnen, Carolien P. Schröder, Sabine C. Linn, Marleen Kok
Publikováno v:
Nature Cancer, 4, 535-549. Springer Nature
Nature Cancer, 4(4), 535-549. Nature Research
Nature Cancer, 4(4), 535-549. Nature Research
Invasive lobular breast cancer (ILC) is the second most common histological breast cancer subtype, but ILC-specific trials are lacking. Translational research revealed an immune-related ILC subset, and in mouse ILC models, synergy between immune chec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173e4cc0d70da59f93de91b9372cee78
https://doi.org/10.1038/s43018-023-00542-x
https://doi.org/10.1038/s43018-023-00542-x
Autor:
Veerle Geurts, Leonie Voorwerk, Karolina Sikorska, Roberto Salgado, Koen van de Vijver, Marloes van Dongen, Inge Kemper, Ingrid A. Mandjes, Martine Heuver-mes, John Haanen, Gabe S. Sonke, Hugo Horlings, Marleen Kok
Publikováno v:
Cancer Research. 83:P3-06
Background Although treatment options and survival of HER2+ metastatic breast cancer (MBC) patients have greatly improved, the majority of MBC-patients still die of this disease. The relatively high levels of TILs observed in this BC subtype provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15a5374bb49d0606a1e6bfc6d3ba9a8e
https://doi.org/10.1158/1538-7445.sabcs22-p3-06-01
https://doi.org/10.1158/1538-7445.sabcs22-p3-06-01
Publikováno v:
Clinical Cancer Research. :OF1-OF9
A substantial fraction of early-stage triple-negative breast cancer (eTNBC) is characterized by high levels of stromal tumor-infiltrating lymphocytes (sTIL) and has a good prognosis even without systemic treatment, highlighting the importance of an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c01386929486bb22a816fe13442bd01
https://doi.org/10.1158/1078-0432.ccr-22-0701
https://doi.org/10.1158/1078-0432.ccr-22-0701
Autor:
Olga S, Blomberg, Lorenzo, Spagnuolo, Hannah, Garner, Leonie, Voorwerk, Olga I, Isaeva, Ewald, van Dyk, Noor, Bakker, Myriam, Chalabi, Chris, Klaver, Maxime, Duijst, Kelly, Kersten, Marieke, Brüggemann, Dorien, Pastoors, Cheei-Sing, Hau, Kim, Vrijland, Elisabeth A M, Raeven, Daphne, Kaldenbach, Kevin, Kos, Inna S, Afonina, Paulien, Kaptein, Louisa, Hoes, Willemijn S M E, Theelen, Paul, Baas, Emile E, Voest, Rudi, Beyaert, Daniela S, Thommen, Lodewyk F A, Wessels, Karin E, de Visser, Marleen, Kok
Publikováno v:
Cancer cell.
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::858404ab7e5b5d36c2dd670afa56af35
https://pubmed.ncbi.nlm.nih.gov/36525971
https://pubmed.ncbi.nlm.nih.gov/36525971
Autor:
Olga S. Blomberg, Lorenzo Spagnuolo, Hannah Garner, Leonie Voorwerk, Olga I. Isaeva, Ewald van Dyk, Noor Bakker, Myriam Chalabi, Chris Klaver, Maxime Duijst, Kelly Kersten, Marieke Brüggemann, Dorien Pastoors, Cheei-Sing Hau, Kim Vrijland, Elisabeth A.M. Raeven, Daphne Kaldenbach, Kevin Kos, Inna S. Afonina, Paulien Kaptein, Louisa Hoes, Willemijn S.M.E. Theelen, Paul Baas, Emile E. Voest, Rudi Beyaert, Daniela S. Thommen, Lodewyk F.A. Wessels, Karin E. de Visser, Marleen Kok
Publikováno v:
CANCER CELL
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad37e511061ec36826986b3010056ea
https://doi.org/10.1016/j.ccell.2022.11.014
https://doi.org/10.1016/j.ccell.2022.11.014
Autor:
Yulong Liang, Daniel J. McGrail, Hui Dai, Christine B. Peterson, Truong Nguyen Anh Lam, Leonie Voorwerk, Patrick G. Pilie, Marleen Kok, Amy B. Heimberger, S.H. Lin, Xiang Zhang, Eric Jonasch, Jeffrey M. Rosen
Publikováno v:
Sci Transl Med
Treatment with immune checkpoint blockade (ICB) has resulted in durable responses for a subset of patients with cancer, with predictive biomarkers for ICB response originally identified largely in the context of hypermutated cancers. Although recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0469e0f1c41d4a649378607be204526b
https://doi.org/10.1126/scitranslmed.abe6201
https://doi.org/10.1126/scitranslmed.abe6201
Autor:
Hayri E. Balcioglu, Iris Nederlof, Mieke Timmermans, John W.M. Martens, Reno Debets, Renée Foekens, Olga I. Isaeva, Rebecca Wijers, Hugo M. Horlings, Marcel Smid, Anita M. A. C. Trapman-Jansen, Dora Hammerl, Roberto Salgado, Leonie Voorwerk, Marleen Kok
Publikováno v:
Nature Communications, 12(1):5668. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Only a subgroup of triple-negative breast cancer (TNBC) responds to immune checkpoint inhibitors (ICI). To better understand lack of response to ICI, we analyze 681 TNBCs for spatial immune cell contextures in relation to clinical outcomes and pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8530b84ca13ab7128ec85fda20aeb5c6
https://pure.eur.nl/en/publications/eb2a9c63-0754-4f32-b5b4-85ff2d2d7052
https://pure.eur.nl/en/publications/eb2a9c63-0754-4f32-b5b4-85ff2d2d7052
Autor:
Leonie Voorwerk, Maggie L. DiNome, Javier I. J. Orozco, Sandra Íñiguez-Muñoz, Kelly E McCann, Miquel Ensenyat-Mendez, Pere Llinàs-Arias, Borja Sesé, Diego M. Marzese
Publikováno v:
Cancers
Cancers, Vol 13, Iss 4139, p 4139 (2021)
Cancers, Vol 13, Iss 4139, p 4139 (2021)
Simple Summary Triple-negative breast cancer (TNBC) outcomes are improving since the implementation of immunotherapy. However, objective response rates are still limited to a select group of patients. This is partly due to TNBC intrinsic immune evasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b370dfb4c52897cc0acdb16d3f71e4
http://europepmc.org/articles/PMC8394958
http://europepmc.org/articles/PMC8394958