Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Leonidas Tsiokas"'
Autor:
Eleni Petsouki, Vasileios Gerakopoulos, Nicholas Szeto, Wenhan Chang, Mary Beth Humphrey, Leonidas Tsiokas
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Petsouki et al. dissect the importance of FBW7-mediated regulation of NDE1 and TALPID3 in mesenchymal stem cells (MSCs). They find that by modulating the abundance of negative (NDE1) and positive (TALPID3) cilia regulators, FBW7 contributes to both t
Externí odkaz:
https://doaj.org/article/a269982ff2f24864a1170fac0d97006f
Autor:
Wang Zheng, Ruiqi Cai, Laura Hofmann, Vasyl Nesin, Qiaolin Hu, Wentong Long, Mohammad Fatehi, Xiong Liu, Shaimaa Hussein, Tim Kong, Jingru Li, Peter E. Light, Jingfeng Tang, Veit Flockerzi, Leonidas Tsiokas, Xing-Zhen Chen
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1560-1573 (2018)
Summary: Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanism
Externí odkaz:
https://doaj.org/article/8e0d032f464f4d0bbee98b4b0c03ace1
Autor:
Maulin M. Patel, Leonidas Tsiokas
Publikováno v:
Cells, Vol 10, Iss 11, p 2977 (2021)
The primary cilium, an antenna-like structure that protrudes out from the cell surface, is present in most cell types. It is a microtubule-based organelle that serves as a mega-signaling center and is important for sensing biochemical and mechanical
Externí odkaz:
https://doaj.org/article/fce71ed181334a9d90579151c5b40ec4
Autor:
Prabir K. Chakraborty, Soumyajit Banerjee Mustafi, Xunhao Xiong, Shailendra Kumar Dhar Dwivedi, Vasyl Nesin, Sounik Saha, Min Zhang, Danny Dhanasekaran, Muralidharan Jayaraman, Robert Mannel, Kathleen Moore, Scott McMeekin, Da Yang, Rosemary Zuna, Kai Ding, Leonidas Tsiokas, Resham Bhattacharya, Priyabrata Mukherjee
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The mitochondrial uniporter MICU1 regulates mitochondrial Ca2+ uptake. Here, the authors show that MICU1 is upregulated in ovarian cancer and confers resistance to cisplatin-induced apoptosis through a Ca2+-mediated regulation of pyruvate dehydrogena
Externí odkaz:
https://doaj.org/article/6eedb1c6824a4f579fb70e3563024a60
Publikováno v:
Cells, Vol 5, Iss 1, p 6 (2016)
Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles on the surface of most eukaryotic cells. They play important roles in coordinating a variety of signaling pathways during growth, development, cell mobility
Externí odkaz:
https://doaj.org/article/949b7a3abcae4b52ba20dda5c215265f
Autor:
Chandra Kumar Elechalawar, Geeta Rao, Suresh Kumar Gulla, Maulin Mukeshchandra Patel, Alex Frickenstein, Nicolas Means, Ram Vinod Roy, Leonidas Tsiokas, Sima Asfa, Prasanta Panja, Chinthalapally Rao, Stefan Wilhelm, Resham Bhattacharya, Priyabrata Mukherjee
Publikováno v:
ACS Nano. 17:9326-9337
Autor:
Jeremy S. Houser, Maulin Patel, Kyle Wright, Marta Onopiuk, Leonidas Tsiokas, Mary Beth Humphrey
Publikováno v:
Blood Cells, Molecules, and Diseases. 102:102760
Publikováno v:
The Journal of Immunology. 208:47.15-47.15
The differentiation of megakaryocytes (Mk) from hematopoietic stem and progenitor cells (HSPC) is crucial to homeostasis and requires tight regulation. Cell-intrinsic factors skew HSPCs towards the Mk lineage and promote terminal differentiation, but
Autor:
Mary Beth Humphrey, Wenhan Chang, Eleni Petsouki, Nicholas Szeto, Leonidas Tsiokas, Vasileios Gerakopoulos
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Structural defects in primary cilia have robust effects in diverse tissues and systems. However, how disorders of ciliary length lead to functional outcomes are unknown. We examined the functional role of a ciliary length control mechanism of FBW7-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cbbc0fdfdff478068b31e03f5cc82d
https://doi.org/10.1101/2020.12.18.423369
https://doi.org/10.1101/2020.12.18.423369
Publikováno v:
Life Science Alliance
Deletion of the polycystins activates components of the centrosomal integrity pathway, resulting in delayed cell deciliation and prolonged activation of cilia-related signaling pathways.
The primary cilium is a microtubule-based, antenna-like or
The primary cilium is a microtubule-based, antenna-like or