Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leonidas G. Baltas"'
Autor:
Gert Baumann, Ingo Morano, Leonidas G. Baltas, Hannelore Haase, Hans Peter Luther, Hagen D. Schulte, Oliver Ritter
Publikováno v:
Journal of Molecular Medicine. 77:677-685
The adult rodent heart adapts to increased work load by reexpression of its fetal genes, for example, beta-myosin heavy chain (MHC), in order to improve contractile function. However, the human ventricle regulates contractility by expression of atria
Autor:
Stephan Rimbach, Gunther Bastert, Diethelm Wallwiener, Leonidas G. Baltas, Ingo Morano, Gunter Erb, Hannelore Haase, Stefan Koehlen
Publikováno v:
Journal of Cellular Biochemistry. 64:171-181
We investigated in vivo expression of myosin heavy chain (MHC) isoforms, 17 kDa myosin light chain (MLC17), and phosphorylation of the 20 kDa MLC (MLC20) as well as mechanical performance of chemically skinned fibers of normal and hypertrophied smoot
Publikováno v:
Basic Research in Cardiology. 92:37-43
Phospholamban (PLB), the regulator of the cardiac sarcoplasmic reticulum (SR) Ca2+ pump is specifically phosphorylated at Ser16 and Thr17 by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin-dependent protein kinase (CaMK), respectively. The re
Publikováno v:
FEBS Letters. 373:71-75
Phospholamban is the regulator of the Ca(2+)-ATPase in cardiac sarcoplasmic reticulum (SR). It is phosphorylated by a Ca2+/calmodulin-dependent protein kinase (SRCaM kinase) which is closely associated with cardiac SR membrane preparations. We found
Publikováno v:
Advances in experimental medicine and biology. 538
Electromechanical coupling by KCl depolarization of bladder preparations elicits an initial phasic and subsequent tonic contraction. Using a smooth-muscle myosin heavy chain (SM-MyHC) knock-out mouse model we could previously demonstrate, that phasic
Autor:
Udo B. Zacharzowsky, Andreas K. Nuessler, Holger Bartsch, Gerhard Wolff, Leonidas G. Baltas, Hannelore Haase, Leonid Karawajew, Ingo Morano, Monika Kott
Publikováno v:
Journal of cellular biochemistry. 86(3)
Expression of the human atrial myosin light chain 1 (hALC-1) in the cardiac ventricle in vivo as well as in primary cultivated adult cardiomyocytes caused a pronounced positive inotropic effect. Therefore, it is one of the most promising candidate ge
Autor:
Ingo Morano, Guixuan Chai, Leonidas G. Baltas, Monika Kott, V Lamounier-Zepter, Gudrun Lutsch, Hannelore Haase, Michael Bader
Publikováno v:
Nature cell biology. 2(6)
Here we have used gene-targeting to eliminate expression of smooth-muscle myosin heavy chain. Elimination of this gene does not affect expression of non-muscle myosin heavy chain, and knockout individuals typically survive for three days. Prolonged a
Publikováno v:
FEBS letters. 409(2)
We investigated the effects of beta-adrenergic stimulation on the activity of the endogenous cardiac sarcoplasmic reticulum Ca2+/calmodulin-dependent protein kinase (SRCaM kinase) in Langendorff-perfused rat hearts. We found that isoproterenol induce
Publikováno v:
Biochemical and biophysical research communications. 232(2)
The effects of zinc on the phosphorylation of phospholamban (PLB) were studied in sarcoplasmic reticulum (SR) membranes prepared from swine ventricular muscle. Zinc produced a dose dependent inhibition of PLB phosphorylation. With the use of phosphor
Autor:
Theodore G. Sotiroudis, Symeon M. Kyriakidis, Leonidas G. Baltas, A.E. Evangelopoulos, Vasilis G. Zevgolis
Publikováno v:
Evolutionary Tinkering in Gene Expression ISBN: 9781468456660
Protein serine and threonine kinases can be classified into individual groups or subclasses on the basis of the type of regulation of their activities (Krebs, 1986). Two of the most intensively studied groups are Ca2+-regulated, i.e. the Ca2+/calmodu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a8657bf14f962131cb690984761d3e6
https://doi.org/10.1007/978-1-4684-5664-6_6
https://doi.org/10.1007/978-1-4684-5664-6_6