Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Leonidas G, Alexopoulos"'
Autor:
Nikos Tsolakos, Linsey E. Haswell, Fabio Miazzi, Emma Bishop, Asier Antoranz, Vaia Pliaka, Angeliki Minia, Leonidas G. Alexopoulos, Marianna Gaca, Damien Breheny
Publikováno v:
Toxicology Reports, Vol 12, Iss , Pp 492-501 (2024)
Cigarette smoking is a risk factor for several diseases such as cancer, cardiovascular disease (CVD), and chronic obstructive pulmonary diseases (COPD), however, the underlying mechanisms are not fully understood. Alternative nicotine products with r
Externí odkaz:
https://doaj.org/article/2549979cf5304ec98b71ea8e5c0999de
Autor:
Keith E Kennedy, Nicole Kerlero de Rosbo, Antonio Uccelli, Maria Cellerino, Federico Ivaldi, Paola Contini, Raffaele De Palma, Hanne F Harbo, Tone Berge, Steffan D Bos, Einar A Høgestøl, Synne Brune-Ingebretsen, Sigrid A de Rodez Benavent, Friedemann Paul, Alexander U Brandt, Priscilla Bäcker-Koduah, Janina Behrens, Joseph Kuchling, Susanna Asseyer, Michael Scheel, Claudia Chien, Hanna Zimmermann, Seyedamirhosein Motamedi, Josef Kauer-Bonin, Julio Saez-Rodriguez, Melanie Rinas, Leonidas G Alexopoulos, Magi Andorra, Sara Llufriu, Albert Saiz, Yolanda Blanco, Eloy Martinez-Heras, Elisabeth Solana, Irene Pulido-Valdeolivas, Elena H Martinez-Lapiscina, Jordi Garcia-Ojalvo, Pablo Villoslada
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1010980 (2024)
Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype for an organism is dictated by the interplay among these scales. W
Externí odkaz:
https://doaj.org/article/c5917d61aa834152b3fb2018484da2fd
Autor:
Alexia Gali, Irene V. Bijnsdorp, Sander R. Piersma, Thang V. Pham, Elena Gutiérrez-Galindo, Fiona Kühnel, Nikos Tsolakos, Connie R. Jimenez, Angelika Hausser, Leonidas G. Alexopoulos
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108958- (2024)
Summary: The protein kinase D (PKD) family members regulate the fission of cargo vesicles at the Golgi complex and play a pro-oncogenic role in triple-negative breast cancer (TNBC). Whether PKD facilitates the secretion of tumor-promoting factors in
Externí odkaz:
https://doaj.org/article/85599656f67044cbafb566e2492ace42
Autor:
Maria Segarra-Queralt, Michael Neidlin, Laura Tio, Jordi Monfort, Joan Carles Monllau, Miguel Á. González Ballester, Leonidas G. Alexopoulos, Gemma Piella, Jérôme Noailly
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract In osteoarthritis (OA), chondrocyte metabolism dysregulation increases relative catabolic activity, which leads to cartilage degradation. To enable the semiquantitative interpretation of the intricate mechanisms of OA progression, we propose
Externí odkaz:
https://doaj.org/article/22d4edc592104ad39a6ec546b3fdbba6
Autor:
Hiroaki Imoto, Nora Rauch, Ashish J. Neve, Fahimeh Khorsand, Martina Kreileder, Leonidas G. Alexopoulos, Jens Rauch, Mariko Okada, Boris N. Kholodenko, Oleksii S. Rukhlenko
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1212 (2023)
Cancer cells often adapt to targeted therapies, yet the molecular mechanisms underlying adaptive resistance remain only partially understood. Here, we explore a mechanism of RAS/RAF/MEK/ERK (MAPK) pathway reactivation through the upregulation of RAF
Externí odkaz:
https://doaj.org/article/7dcb85afd59b4b5ebacd96250fa08b80
Autor:
Marti Bernardo-Faura, Melanie Rinas, Jakob Wirbel, Inna Pertsovskaya, Vicky Pliaka, Dimitris E. Messinis, Gemma Vila, Theodore Sakellaropoulos, Wolfgang Faigle, Pernilla Stridh, Janina R. Behrens, Tomas Olsson, Roland Martin, Friedemann Paul, Leonidas G. Alexopoulos, Pablo Villoslada, Julio Saez-Rodriguez
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)
Abstract Background Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system is a hallmark of the disease, its pathogenesis is poorly understood, wh
Externí odkaz:
https://doaj.org/article/d0283f3687a1440293ae0739ffafff56
Autor:
Aphrodite Daskalopoulou, Sotiria G. Giotaki, Konstantina Toli, Angeliki Minia, Vaia Pliaka, Leonidas G. Alexopoulos, Gerasimos Deftereos, Konstantinos Iliodromitis, Dimitrios Dimitroulis, Gerasimos Siasos, Christos Verikokos, Dimitrios Iliopoulos
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1273 (2023)
Background: There is a need for clinical markers to aid in the detection of individuals at risk of harboring an ascending thoracic aneurysm (ATAA) or developing one in the future. Objectives: To our knowledge, ATAA remains without a specific biomarke
Externí odkaz:
https://doaj.org/article/8e23e341ab3b4fc994ce2199e585718a
Autor:
Christos Fotis, Nikolaos Meimetis, Nikos Tsolakos, Marianna Politou, Karolina Akinosoglou, Vaia Pliaka, Angeliki Minia, Evangelos Terpos, Ioannis P. Trougakos, Andreas Mentis, Markos Marangos, George Panayiotakopoulos, Meletios A. Dimopoulos, Charalampos Gogos, Alexandros Spyridonidis, Leonidas G. Alexopoulos
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract There is a plethora of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) serological tests based either on nucleocapsid phosphoprotein (N), S1-subunit of spike glycoprotein (S1) or receptor binding domain (RBD). Although these sin
Externí odkaz:
https://doaj.org/article/858a40ad7d234e85a90d69d2e74774df
Autor:
Paola Bermudez-Lekerika, Katherine B. Crump, Sofia Tseranidou, Andrea Nüesch, Exarchos Kanelis, Ahmad Alminnawi, Laura Baumgartner, Estefano Muñoz-Moya, Roger Compte, Francesco Gualdi, Leonidas G. Alexopoulos, Liesbet Geris, Karin Wuertz-Kozak, Christine L. Le Maitre, Jérôme Noailly, Benjamin Gantenbein
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Low back pain is a highly prevalent, chronic, and costly medical condition predominantly triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and biochemical changes in intervertebral discs (IVD) that prompt a pathol
Externí odkaz:
https://doaj.org/article/15f20c230e9b49f080b2b6b86432f7e5
Autor:
Ferenc Tajti, Christoph Kuppe, Asier Antoranz, Mahmoud M. Ibrahim, Hyojin Kim, Francesco Ceccarelli, Christian H. Holland, Hannes Olauson, Jürgen Floege, Leonidas G. Alexopoulos, Rafael Kramann, Julio Saez-Rodriguez
Publikováno v:
Kidney International Reports, Vol 5, Iss 2, Pp 211-224 (2020)
Introduction: To develop effective therapies and identify novel early biomarkers for chronic kidney disease, an understanding of the molecular mechanisms orchestrating it is essential. We here set out to understand how differences in chronic kidney d
Externí odkaz:
https://doaj.org/article/5e417b63360844a8b56b9ab8d28548ee