Zobrazeno 1 - 10
of 551
pro vyhledávání: '"Leonidas C. Platanias"'
Autor:
Sara Small, Elspeth Beauchamp, Mariafausta Fischietti, Ricardo E. Perez, Leonidas C. Platanias
Publikováno v:
HemaSphere, Vol 7, p e47902a4 (2023)
Externí odkaz:
https://doaj.org/article/fb91009a0e254690b00057a90ec8729b
Publikováno v:
Haematologica, Vol 108, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/86c4de73a88d482b8e7bbe94b77ba18e
Autor:
Diana Saleiro, Jeremy Q. Wen, Ewa M. Kosciuczuk, Frank Eckerdt, Elspeth M. Beauchamp, Chidera V. Oku, Gavin T. Blyth, Mariafausta Fischietti, Liliana Ilut, Marco Colamonici, William Palivos, Paula A. Atsaves, Dean Tan, Masha Kocherginsky, Rona Singer Weinberg, Eleanor N. Fish, John D. Crispino, Ronald Hoffman, Leonidas C. Platanias
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Interferon alpha (IFNalpha) therapy is showing promising results to treat myeloproliferative neoplasms (MPNs). Here, the authors show that IFNalpha response requires ULK1 phosphorylation to induce p38-MAPK signalling but it is counteracted by ROCK1-2
Externí odkaz:
https://doaj.org/article/3a0f1e5129e84efda5acd4754ca85e1b
Autor:
Frank D. Eckerdt, Jonathan B. Bell, Christopher Gonzalez, Michael S. Oh, Ricardo E. Perez, Candice Mazewski, Mariafausta Fischietti, Stewart Goldman, Ichiro Nakano, Leonidas C. Platanias
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Glioblastoma (GBM) is the most common and lethal primary intrinsic tumour of the adult brain and evidence indicates disease progression is driven by glioma stem cells (GSCs). Extensive advances in the molecular characterization of GBM allowe
Externí odkaz:
https://doaj.org/article/bb07ee97883b447baba480ea2552c1ef
Autor:
Hinda Najem, Martina Ott, Cynthia Kassab, Arvind Rao, Ganesh Rao, Anantha Marisetty, Adam M. Sonabend, Craig Horbinski, Roel Verhaak, Anand Shankar, Santhoshi N. Krishnan, Frederick S. Varn, Víctor A. Arrieta, Pravesh Gupta, Sherise D. Ferguson, Jason T. Huse, Gregory N. Fuller, James P. Long, Daniel E. Winkowski, Ben A. Freiberg, Charles David James, Leonidas C. Platanias, Maciej S. Lesniak, Jared K. Burks, Amy B. Heimberger
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
BACKGROUND Immune cell profiling of primary and metastatic CNS tumors has been focused on the tumor, not the tumor microenvironment (TME), or has been analyzed via biopsies.METHODS En bloc resections of gliomas (n = 10) and lung metastases (n = 10) w
Externí odkaz:
https://doaj.org/article/ee2104f14ae1491f89501b1b618cfbda
Autor:
Andrew A. Davis, Qiang Zhang, Lorenzo Gerratana, Ami N. Shah, Youbin Zhan, Wenan Qiang, Brian S. Finkelman, Lisa Flaum, Amir Behdad, William J. Gradishar, Leonidas C. Platanias, Massimo Cristofanilli
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-8 (2019)
Abstract Purpose Liquid biopsies, including circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs), can be used to understand disease prognosis, tumor heterogeneity, and dynamic response to treatment in metastatic breast cancer (MBC). We ex
Externí odkaz:
https://doaj.org/article/40cd0501b4a249ad80a0c2b4426a8492
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14543 (2022)
Despite many recent advances in treatment options, acute myeloid leukemia (AML) still has a high mortality rate. One important issue in optimizing outcomes for AML patients lies in the limited ability to predict response to specific therapies, durati
Externí odkaz:
https://doaj.org/article/0172668aad74457798722e58f5e1f3d6
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
For several decades there has been accumulating evidence implicating type I interferons (IFNs) as key elements of the immune response. Therapeutic approaches incorporating different recombinant type I IFN proteins have been successfully employed to t
Externí odkaz:
https://doaj.org/article/a0ba1ca538a34745a55667a2a5738a49
Autor:
Andrew A. Davis, Saya Jacob, Lorenzo Gerratana, Ami N. Shah, Firas Wehbe, Neelima Katam, Qiang Zhang, Lisa Flaum, Kalliopi P. Siziopikou, Leonidas C. Platanias, William J. Gradishar, Amir Behdad, Massimo Cristofanilli
Publikováno v:
EBioMedicine, Vol 58, Iss , Pp 102914- (2020)
Background: We describe the genomic landscape of circulating tumour DNA (ctDNA) across pathological subtypes of metastatic breast cancer. Methods: 255 clinically annotated patients with ctDNA testing by Guardant360 were stratified into HR+, HER2+, an
Externí odkaz:
https://doaj.org/article/7c72c58ca777465db403e0194fc0c7e0
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1631 (2021)
Similar to other cancers, myeloid malignancies are thought to subvert the immune system during their development. This subversion occurs via both malignant cell-autonomous and non-autonomous mechanisms and involves manipulation of the innate and adap
Externí odkaz:
https://doaj.org/article/ae3df64a813045f1920fbc5ebf226af4