Zobrazeno 1 - 10
of 545
pro vyhledávání: '"Leonidas C Platanias"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78780 (2013)
Chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) are characterized by the presence of the BCR-ABL oncoprotein, which leads to activation of a plethora of pro-mitogenic and pro-survival pathways, including the mTOR signaling c
Externí odkaz:
https://doaj.org/article/24052efa13034cfc8650dcc815e472d7
Autor:
Azhar R Hussain, Saeeda O Ahmed, Maqbool Ahmed, Omar S Khan, Sally Al Abdulmohsen, Leonidas C Platanias, Khawla S Al-Kuraya, Shahab Uddin
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39945 (2012)
A number of constitutively activated signaling pathways play critical roles in the survival and growth of primary effusion lymphoma cells (PELs) including NFkB and PI3/AKT kinase cascades. NFkBis constitutively activated in a number of malignancies,
Externí odkaz:
https://doaj.org/article/819a721147874dbdaee01691b9f7035d
Autor:
Sara Small, Elspeth Beauchamp, Mariafausta Fischietti, Ricardo E. Perez, Leonidas C. Platanias
Publikováno v:
HemaSphere, Vol 7, p e47902a4 (2023)
Externí odkaz:
https://doaj.org/article/fb91009a0e254690b00057a90ec8729b
Publikováno v:
Haematologica, Vol 108, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/86c4de73a88d482b8e7bbe94b77ba18e
Autor:
Diana Saleiro, Jeremy Q. Wen, Ewa M. Kosciuczuk, Frank Eckerdt, Elspeth M. Beauchamp, Chidera V. Oku, Gavin T. Blyth, Mariafausta Fischietti, Liliana Ilut, Marco Colamonici, William Palivos, Paula A. Atsaves, Dean Tan, Masha Kocherginsky, Rona Singer Weinberg, Eleanor N. Fish, John D. Crispino, Ronald Hoffman, Leonidas C. Platanias
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Interferon alpha (IFNalpha) therapy is showing promising results to treat myeloproliferative neoplasms (MPNs). Here, the authors show that IFNalpha response requires ULK1 phosphorylation to induce p38-MAPK signalling but it is counteracted by ROCK1-2
Externí odkaz:
https://doaj.org/article/3a0f1e5129e84efda5acd4754ca85e1b
Autor:
Diana Saleiro, Ewa M. Kosciuczuk, Mariafausta Fischietti, Ricardo E. Perez, G. Sohae Yang, Frank Eckerdt, Elspeth M. Beauchamp, Ye Hou, Qixuan Wang, Rona Singer Weinberg, Eleanor N. Fish, Feng Yue, Ronald Hoffman, Leonidas C. Platanias
Publikováno v:
Cancer Research Communications. 3:943-951
Interferons (IFNs) are cytokines with potent antineoplastic and antiviral properties. IFNα has significant clinical activity in the treatment of myeloproliferative neoplasms (MPN), but the precise mechanisms by which it acts are not well understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc08a67b4a95eb295e0a55a7cae3a24c
https://doi.org/10.1158/2767-9764.crc-23-0010
https://doi.org/10.1158/2767-9764.crc-23-0010
Autor:
Candice Mazewski, Leonidas C Platanias
Publikováno v:
OncoTargets and Therapy. 16:283-295
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5037a3c68e9d7f35761a50fe20fe119
https://doi.org/10.2147/ott.s370874
https://doi.org/10.2147/ott.s370874
Publikováno v:
Expert opinion on pharmacotherapy. 23(13)
With advances in molecular medicine and precision approaches, there has been significant improvement in the treatment of acute myeloid leukemia (AML) in recent years. This reflects better understanding of molecular and metabolic pathways in leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876f6db66715e4df79f61666c8f70c6c
https://pubmed.ncbi.nlm.nih.gov/35938317
https://pubmed.ncbi.nlm.nih.gov/35938317
Autor:
Hongxia Chen, Yunpeng Bai, Michihiro Kobayashi, Shiyu Xiao, Wenjie Cai, Sergio Barajas, Sisi Chen, Jinmin Miao, Frederick Nguele Meke, Sasidhar Vemula, James P. Ropa, James M. Croop, H. Scott Boswell, Jun Wan, Yuzhi Jia, Huiping Liu, Loretta S. Li, Jessica K. Altman, Elizabeth A. Eklund, Peng Ji, Wei Tong, Hamid Band, Danny T. Huang, Leonidas C. Platanias, Zhong-Yin Zhang, Yan Liu
Publikováno v:
Blood. 141:244-259
Acute myeloid leukemia (AML) is an aggressive blood cancer with poor prognosis. FMS-like tyrosine kinase receptor-3 (FLT3) is one of the major oncogenic receptor tyrosine kinases aberrantly activated in AML. Although protein tyrosine phosphatase PRL2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba45e7977ff76b91425c2b3b3f267450
https://doi.org/10.1182/blood.2022016580
https://doi.org/10.1182/blood.2022016580
Autor:
Sarah E. Fenton, Markella Zannikou, Liliana Ilut, Mariafausta Fischietti, Chunni Ji, Chidera V. Oku, Curt M. Horvath, I. Caroline Le Poole, Marcus Bosenberg, Elizabeth T. Bartom, Masha Kocherginsky, Leonidas C. Platanias, Diana Saleiro
Publikováno v:
Molecular Cancer Research. 21:332-344
Immune checkpoint inhibitors (ICI) have transformed the treatment of melanoma. However, the majority of patients have primary or acquired resistance to ICIs, limiting durable responses and patient survival. IFNγ signaling and the expression of IFNγ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c421fef04efa91ec5f424805584db4d
https://doi.org/10.1158/1541-7786.mcr-22-0684
https://doi.org/10.1158/1541-7786.mcr-22-0684