Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Leonidas Benetatos"'
Autor:
Eleftheria Hatzimichael, Despoina Timotheatou, Epameinondas Koumpis, Leonidas Benetatos, Alexandros Makis
Publikováno v:
Diseases, Vol 10, Iss 4, p 85 (2022)
Anemia is a common feature of both benign and malignant hematologic diseases. Beta-thalassemia (β-thalassemia) syndromes are a group of hereditary disorders characterized by ineffective erythropoiesis, due to a genetic deficiency in the synthesis of
Externí odkaz:
https://doaj.org/article/dc975bab5b37417d97d1481634b4a9cc
Autor:
Panagiota K. Petsa, Achilleas Karamoutsios, Lefkothea Dova, Leonidas Benetatos, Asimina Petsiou, Nikolaos Kolaitis, Antonis Georgopoulos, Georgios Vartholomatos
Publikováno v:
Clinics and Practice, Vol 2, Iss 3 (2012)
T-cell large granular lymphocyte (T-LGL) leukemia represents a clonal proliferation of cytotoxic T-cells which etiology has not been entirely elucidated. However, CD4+, CD4–,CD8–, CD4+, CD8+ cases have been described. The disease is usually chara
Externí odkaz:
https://doaj.org/article/e8934a83dab7444b8ca9dd52cd046aef
Publikováno v:
Annals of Hematology. 99:2231-2242
Long non-coding RNAs (lncRNAs) have an established role in cell biology. Among their functions is the regulation of hematopoiesis. They characterize the different stages of hematopoiesis in a more lineage-restricted expression pattern than coding mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de794d41ef43577b94d7bbb4f6b328f8
https://doi.org/10.1007/s00277-020-04166-4
https://doi.org/10.1007/s00277-020-04166-4
Publikováno v:
Journal of Molecular Medicine. 98:471-481
Transcription requires the fine interplay between enhancers and transcription factors. Enhancers are able to activate transcription of genes involved in normal cell biology, whereas aberrant enhancer activity leads to oncogenesis. MYC is a well-estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd86efeb3030d24557ec1ea4e0087c54
https://doi.org/10.1007/s00109-020-01891-1
https://doi.org/10.1007/s00109-020-01891-1
Publikováno v:
Medical oncology (Northwood, London, England). 39(10)
DNA methylation has a well-established role in the pathogenesis, prognosis, and response to treatment in all the spectra of hematological malignancies. However, most of the data reported involve average DNA methylation observed in a sample. The emerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fb20dd484c93b51ebec2303f05d24c
https://pubmed.ncbi.nlm.nih.gov/35834015
https://pubmed.ncbi.nlm.nih.gov/35834015
Publikováno v:
Annals of Hematology. 95:1571-1582
DNA methylation is the most common epigenetic modification in the mammalian genome. DNA methylation is governed by the DNA methyltransferases mainly DNMT1, DNMT3A, and DNMT3B. DNMT1 methylates hemimethylated DNA ensuring accurate DNA methylation main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf695dc7cf0660923d77b76fe41f0936
https://doi.org/10.1007/s00277-016-2636-8
https://doi.org/10.1007/s00277-016-2636-8
Publikováno v:
Medical oncology (Northwood, London, England). 34(3)
Long non-coding RNAs (lncRNAs) are able to positively or negatively regulate other genes expression in cis or in trans. Their effect can be achieved through RNA-protein, RNA-DNA, or RNA-RNA interactions. They can recruit transcription factors and act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a35654f6b8c4967d01e3b91acb0ea67
https://pubmed.ncbi.nlm.nih.gov/28176240
https://pubmed.ncbi.nlm.nih.gov/28176240
Publikováno v:
Cellular and Molecular Life Sciences. 71:4421-4430
DLK1-DIO3 represents an imprinted cluster which genes are involved in physiological cell biology as early as the stem cell level and in the pathogenesis of several diseases. Transcription factor-mediated induced pluripotent cells (iPSCs) are consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02451e0589d86d561bd9efa25c45973
https://doi.org/10.1007/s00018-014-1698-9
https://doi.org/10.1007/s00018-014-1698-9
Publikováno v:
Annals of Hematology. 92:1439-1450
MicroRNAs are short noncoding RNAs, known regulators of several signaling pathways cell differentiation and proliferation, development, and apoptosis, which are deregulated in acute leukemia. Mixed lineage leukemia (MLL) gene encodes a protein with h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e648ce48b8aa889703d4c07ed6a5e887
https://doi.org/10.1007/s00277-013-1803-4
https://doi.org/10.1007/s00277-013-1803-4
Autor:
Phillipe Loher, Eleftheria Hatzimichael, Isidore Rigoutsos, Leonidas Benetatos, Eric Londin, Evangelos Briasoulis, George Vartholomatos
Publikováno v:
Cellular and Molecular Life Sciences. 70:795-814
The mammalian genome is transcribed in a developmentally regulated manner, generating RNA strands ranging from long to short non-coding RNA (ncRNAs). NcRNAs generated by intergenic sequences and protein-coding loci, represent up to 98 % of the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42bf95b17f3008e1f5765a959eeb8b4d
https://doi.org/10.1007/s00018-012-1080-8
https://doi.org/10.1007/s00018-012-1080-8