Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Leonid Tyan"'
Autor:
Emily Sempou, Valentyna Kostiuk, Jie Zhu, M. Cecilia Guerra, Leonid Tyan, Woong Hwang, Elena Camacho-Aguilar, Michael J. Caplan, David Zenisek, Aryeh Warmflash, Nick D. L. Owens, Mustafa K. Khokha
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Transitioning from pluripotency to differentiated cell fates is fundamental to both embryonic development and adult tissue homeostasis. Improving our understanding of this transition would facilitate our ability to manipulate pluripotent cel
Externí odkaz:
https://doaj.org/article/58862aeb53a640a4ba563a0187c09257
Autor:
Emily Sempou, Valentyna Kostiuk, Jie Zhu, M. Cecilia Guerra, Leonid Tyan, Woong Hwang, Elena Camacho-Aguilar, Michael J. Caplan, David Zenisek, Aryeh Warmflash, Nick D. L. Owens, Mustafa K. Khokha
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/32a4bc62762c4d869617691f1d6c7801
Autor:
Yuriy V. Egorov, Di Lang, Leonid Tyan, Daniel Turner, Evi Lim, Zachary D. Piro, Jonathan J. Hernandez, Rylie Lodin, Rose Wang, Eric G. Schmuck, Amish N. Raval, Carter J. Ralphe, Timothy J. Kamp, Leonid V. Rosenshtraukh, Alexey V. Glukhov
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 20 (2019)
Background Atrial fibrillation often occurs in the setting of hypertension and associated atrial dilation with pathologically increased cardiomyocyte stretch. In the setting of atrial dilation, mechanoelectric feedback has been linked to the developm
Externí odkaz:
https://doaj.org/article/f0cffe821e2a46e59e63602870d31e8b
Autor:
Wenli Dai, Brigitte Laforest, Leonid Tyan, Kaitlyn M Shen, Rangarajan D Nadadur, Francisco J Alvarado, Stefan R Mazurek, Sonja Lazarevic, Margaret Gadek, Yitang Wang, Ye Li, Hector H Valdivia, Le Shen, Michael T Broman, Ivan P Moskowitz, Christopher R Weber
Publikováno v:
eLife, Vol 8 (2019)
Risk for Atrial Fibrillation (AF), the most common human arrhythmia, has a major genetic component. The T-box transcription factor TBX5 influences human AF risk, and adult-specific Tbx5-mutant mice demonstrate spontaneous AF. We report that TBX5 is c
Externí odkaz:
https://doaj.org/article/5542066897174d2fb4a630960edaea63
Autor:
Xinan H Yang, Rangarajan D Nadadur, Catharina RE Hilvering, Valerio Bianchi, Michael Werner, Stefan R Mazurek, Margaret Gadek, Kaitlyn M Shen, Joseph Aaron Goldman, Leonid Tyan, Jenna Bekeny, Johnathon M Hall, Nutishia Lee, Carlos Perez-Cervantes, Ozanna Burnicka-Turek, Kenneth D Poss, Christopher R Weber, Wouter de Laat, Alexander J Ruthenburg, Ivan P Moskowitz
Publikováno v:
eLife, Vol 6 (2017)
The noncoding genome is pervasively transcribed. Noncoding RNAs (ncRNAs) generated from enhancers have been proposed as a general facet of enhancer function and some have been shown to be required for enhancer activity. Here we examine the transcript
Externí odkaz:
https://doaj.org/article/483cf25f032e4eb3bd37b9b1b0cee643
Autor:
Daniel G.P. Turner, Leonid Tyan, Frank C. DeGuire, Roman Y. Medvedev, Sami J. Stroebel, Di Lang, Alexey V. Glukhov
Publikováno v:
Biophys J
Caveola membrane structures harbor mechanosensitive chloride channels (MCCs; including chloride channel 2, chloride channel 3, and SWELL1, also known as LRRC8A) that form a swelling-activated chloride current (I(Cl,swell)) and play an important role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8c1a0f00b8f7e1920cd30a035c07e2
https://doi.org/10.1016/j.bpj.2022.04.001
https://doi.org/10.1016/j.bpj.2022.04.001
Publikováno v:
Am J Physiol Heart Circ Physiol
Angiotensin II (AngII) is a key mediator of the renin-angiotensin system and plays an important role in the regulation of cardiac electrophysiology by affecting various cardiac ion currents, including transient outward potassium current, I(to). AngII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d8dfeccd581e5f3d2c22ce19b87709
https://doi.org/10.1152/ajpheart.00569.2020
https://doi.org/10.1152/ajpheart.00569.2020
Publikováno v:
Am J Physiol Heart Circ Physiol
Various experimental mouse models are extensively used to research human diseases, including atrial fibrillation, the most common cardiac rhythm disorder. Despite this, there are no comprehensive mathematical models that describe the complex behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf6f1c4f1544e28872667a18507354e
https://doi.org/10.1152/ajpheart.00460.2019
https://doi.org/10.1152/ajpheart.00460.2019
Publikováno v:
Circulation Research. 129
Background: Caveolae membrane structures harbor mechanosensitive chloride channels (MCCs) which form a swelling-activated chloride current ( I Cl,swell ) and play an important role in cell volume regulation and mechano-electrical signal transduction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aba1fe5e8eb2da5eacc10879c9843536
https://doi.org/10.1161/res.129.suppl_1.p368
https://doi.org/10.1161/res.129.suppl_1.p368
Autor:
Christopher R. Weber, Kaitlyn M Shen, Michael Broman, Margaret Gadek, Leonid Tyan, Ivan P. Moskowitz, Wenli Dai, Brigitte Laforest, Sonja Lazarevic
Publikováno v:
Journal of Clinical Investigation. 129:4937-4950
Atrial fibrillation (AF), defined by disorganized atrial cardiac rhythm, is the most prevalent cardiac arrhythmia worldwide. Recent genetic studies have highlighted a major heritable component and identified numerous loci associated with AF risk, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05737b7f1e8fad3b50c1dcb4cf0b2e36
https://doi.org/10.1172/jci124231
https://doi.org/10.1172/jci124231