Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Leonid S. Metelitsa"'
Autor:
Elisa Landoni, Mark G. Woodcock, Gabriel Barragan, Gabriele Casirati, Vincenzo Cinella, Simone Stucchi, Leah M. Flick, Tracy A. Withers, Hanna Hudson, Giulia Casorati, Paolo Dellabona, Pietro Genovese, Barbara Savoldo, Leonid S. Metelitsa, Gianpietro Dotti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Human natural killer T cells (NKTs) are innate-like T lymphocytes increasingly used for cancer immunotherapy. Here we show that human NKTs expressing the pro-inflammatory cytokine interleukin-12 (IL-12) undergo extensive and sustained molecu
Externí odkaz:
https://doaj.org/article/a48e168e6afd41a0a78d021d474cf617
Autor:
Elisa Landoni, Mark G. Woodcock, Gabriel Barragan, Gabriele Casirati, Vincenzo Cinella, Simone Stucchi, Leah M. Flick, Tracy A. Withers, Hanna Hudson, Giulia Casorati, Paolo Dellabona, Pietro Genovese, Barbara Savoldo, Leonid S. Metelitsa, Gianpietro Dotti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/472487173e704ef3ad30fb9dddbe2c08
Autor:
Ho Ngai, Gabriel A. Barragan, Gengwen Tian, Julien C. Balzeau, Chunchao Zhang, Amy N. Courtney, Linjie Guo, Xin Xu, Michael S. Wood, Janice M. Drabek, Thorsten Demberg, Caroline M. Sands, Cynthia N. Chauvin-Fleurence, Erica J. Di Pierro, Jeffrey M. Rosen, Leonid S. Metelitsa
Publikováno v:
Cancer Immunology Research. 11:171-183
Vα24-invariant natural killer T cells (NKT) possess innate antitumor properties that can be exploited for cancer immunotherapy. We have shown previously that the CD62L+ central memory-like subset of these cells drives the in vivo antitumor activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266a7555c7aed7fade7dfb0cb68f67ab
https://doi.org/10.1158/2326-6066.cir-22-0333
https://doi.org/10.1158/2326-6066.cir-22-0333
Autor:
David H. M. Steffin, Ibrahim N. Muhsen, LaQuisa C. Hill, Carlos A. Ramos, Nabil Ahmed, Meenakshi Hegde, Tao Wang, Mengfen Wu, Stephen Gottschalk, Sarah B. Whittle, Premal D. Lulla, Maksim Mamonkin, Bilal Omer, Rayne H. Rouce, Andras Heczey, Leonid S. Metelitsa, Bambi J. Grilley, Catherine Robertson, Virginia Torrano, Natalia Lapteva, Adrian P. Gee, Cliona M. Rooney, Malcolm K. Brenner, Helen E. Heslop
Publikováno v:
Blood. 140:16-24
Subsequent malignancies are well-documented complications in long-term follow-up of cancer patients. Recently, genetically modified immune effector (IE) cells have shown benefit in hematologic malignancies and are being evaluated in clinical trials f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcbd710cd0342ff21ad6200231b66fa
https://doi.org/10.1182/blood.2022015728
https://doi.org/10.1182/blood.2022015728
Autor:
Andras Heczey, Xin Xu, Amy N. Courtney, Gengwen Tian, Gabriel A. Barragan, Linjie Guo, Claudia Martinez Amador, Nisha Ghatwai, Purva Rathi, Michael S. Wood, Yanchuan Li, Chunchao Zhang, Thorsten Demberg, Erica J. Di Pierro, Andrew C. Sher, Huimin Zhang, Birju Mehta, Sachin G. Thakkar, Bambi Grilley, Tao Wang, Brian D. Weiss, Antonino Montalbano, Meena Subramaniam, Chenling Xu, Chirag Sachar, Daniel K. Wells, Gianpietro Dotti, Leonid S. Metelitsa
Publikováno v:
Nature Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b13a82f4a138ed6484a1cd3ee3f4400
https://doi.org/10.1038/s41591-023-02363-y
https://doi.org/10.1038/s41591-023-02363-y
Autor:
Barbara Savoldo, Gianpietro Dotti, Leonid S. Metelitsa, Benjamin G. Vincent, Chuang Sun, Yuhui Chen, Giovanni Fucá, Christof C. Smith, Elisa Landoni
T-cell receptor (TCR) gene transfer redirects T cells to target intracellular antigens. However, the potential autoreactivity generated by TCR mispairing and occurrence of graft-versus-host disease in the allogenic setting due to the retention of nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505bbd89edd6746b52fbbfa1900f77d8
https://doi.org/10.1158/2326-6066.c.6550005.v1
https://doi.org/10.1158/2326-6066.c.6550005.v1
Autor:
Cliona M. Rooney, Stephen M. Gottschalk, Leonid S. Metelitsa, Natalia Lapteva, Bilal Omer, Mai Huynh, Charlotte Rivas, Robin Parihar
Fig. S1 shows characterization of GD2-specific CAR-T cells. Fig. S2 shows characterization of human MDSCs. Fig. S3 shows characterization of TME xenograft model. Fig. S4 shows GD2.CAR-T cell homing and infiltration into MDSC-containing tumors after N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172e235632002cb49c80bddf805cc570
https://doi.org/10.1158/2326-6066.22542165.v1
https://doi.org/10.1158/2326-6066.22542165.v1
Autor:
Leonid S. Metelitsa, Jeffrey M. Rosen, Erica J. Di Pierro, Cynthia N. Chauvin-Fleurence, Caroline M. Sands, Thorsten Demberg, Janice M. Drabek, Michael S. Wood, Xin Xu, Linjie Guo, Amy N. Courtney, Chunchao Zhang, Julien C. Balzeau, Gengwen Tian, Gabriel A. Barragan, Ho Ngai
Vα24-invariant natural killer T cells (NKT) possess innate antitumor properties that can be exploited for cancer immunotherapy. We have shown previously that the CD62L+ central memory-like subset of these cells drives the in vivo antitumor activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d6cf153beb90dc3f199a90187225a8
https://doi.org/10.1158/2326-6066.c.6551202
https://doi.org/10.1158/2326-6066.c.6551202
Autor:
Barbara Savoldo, Gianpietro Dotti, Leonid S. Metelitsa, Benjamin G. Vincent, Chuang Sun, Yuhui Chen, Giovanni Fucá, Christof C. Smith, Elisa Landoni
Supplementary Figures and legends for Figures S6-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647adedb608045fbe72ebb82b29a85fc
https://doi.org/10.1158/2326-6066.22542639.v1
https://doi.org/10.1158/2326-6066.22542639.v1
Autor:
Barbara Savoldo, Gianpietro Dotti, Leonid S. Metelitsa, Benjamin G. Vincent, Chuang Sun, Yuhui Chen, Giovanni Fucá, Christof C. Smith, Elisa Landoni
Supplementary figures and legends for Figures S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1105efc093b9987452ec2df7ce1e8305
https://doi.org/10.1158/2326-6066.22542642
https://doi.org/10.1158/2326-6066.22542642