Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Leonid S Brown"'
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110643 (2014)
A homologue of type I rhodopsin was found in the unicellular Gloeobacter violaceus PCC7421, which is believed to be primitive because of the lack of thylakoids and peculiar morphology of phycobilisomes. The Gloeobacter rhodopsin (GR) gene encodes a p
Externí odkaz:
https://doaj.org/article/d90a9e7f48694edf84fa7ad16755638e
Autor:
Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Elena G. Govorunova, Oleg A. Sineshchekov, Yumei Wang, Lei Zheng, Éva Bertalan, Ana-Nicoleta Bondar, Azam Askari, Leonid S. Brown, John L. Spudich, Oliver P. Ernst
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) is a light-gated channel used for optogenetic silencing of mammalian neurons. It selects K+ over Na+ in the absence of the canonical tetrameric K+ selectivity filter found univ
Externí odkaz:
https://doaj.org/article/4df751c792bb444bae38a92d509b0e3d
Autor:
Elena G. Govorunova, Oleg A. Sineshchekov, Leonid S. Brown, Ana-Nicoleta Bondar, John L. Spudich
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Potassium-selective channelrhodopsins (KCRs) are light-gated K+ channels recently found in the stramenopile protist Hyphochytrium catenoides. When expressed in neurons, KCRs enable high-precision optical inhibition of spiking (optogenetic si
Externí odkaz:
https://doaj.org/article/6c367106a20741388c92353aaae743a9
Autor:
Elena G. Govorunova, Oleg A. Sineshchekov, Hai Li, Yumei Wang, Leonid S. Brown, Alyssa Palmateer, Michael Melkonian, Shifeng Cheng, Eric Carpenter, Jordan Patterson, Gane K.-S. Wong, John L. Spudich
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Cation and anion channelrhodopsins (CCRs and ACRs, respectively) primarily from two algal species, Chlamydomonas reinhardtii and Guillardia theta, have become widely used as optogenetic tools to control cell membrane potential with light. We
Externí odkaz:
https://doaj.org/article/c53e961158494961a6504a84794cf01b
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Studying the unfolding of membrane proteins in a native-like lipid environment is challenging. Here the authors describe a method combining hydrogen-deuterium exchange and solid-state NMR measurements that allows the characterization of unfolding eve
Externí odkaz:
https://doaj.org/article/598def11c2fc4bcd97e663bc018acd2a
Autor:
Oleg A. Sineshchekov, Elena G. Govorunova, Hai Li, Yumei Wang, Michael Melkonian, Gane K.-S. Wong, Leonid S. Brown, John L. Spudich
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Channelrhodopsins guide algal phototaxis and are widely used as optogenetic probes for control of membrane potential with light. “Bacteriorhodopsin-like” cation channelrhodopsins (BCCRs) from cryptophytes differ in primary structure from
Externí odkaz:
https://doaj.org/article/9e1672b12d674b958bd9f2860372ea25
Autor:
Masahiro Sugiura, Kazuki Ishikawa, Kota Katayama, Yuji Sumii, Rei Abe-Yoshizumi, Satoshi P. Tsunoda, Yuji Furutani, Norio Shibata, Leonid S. Brown, Hideki Kandori
Publikováno v:
The Journal of Physical Chemistry Letters. 13:9539-9543
Microbial and animal rhodopsins possess retinal chromophores which capture light and normally photoisomerize from all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8c99bec4e7513b858ea8e529ff3716
https://doi.org/10.1021/acs.jpclett.2c02334
https://doi.org/10.1021/acs.jpclett.2c02334
Autor:
Partha Malakar, Ishita Das, Sudeshna Bhattacharya, Andrew Harris, Mordechai Sheves, Leonid S. Brown, Sanford Ruhman
Publikováno v:
The Journal of Physical Chemistry Letters. 13:8134-8140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4769642569ebb5cce077580d5c484fc3
https://doi.org/10.1021/acs.jpclett.2c01974
https://doi.org/10.1021/acs.jpclett.2c01974
Publikováno v:
Frontiers in molecular neuroscience. 15
Channelrhodopsins (ChRs) are proteins that guide phototaxis in protists and exhibit light-gated channel conductance when their genes are heterologously expressed in mammalian cells. ChRs are widely used as molecular tools to control neurons and cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430b3b380376b039dfcf8c0aee20baa8
https://pubmed.ncbi.nlm.nih.gov/36017077
https://pubmed.ncbi.nlm.nih.gov/36017077
Autor:
Oleg A. Sineshchekov, Yumei Wang, Elena G. Govorunova, Leonid S. Brown, Hai Li, John L. Spudich
Publikováno v:
Proc Natl Acad Sci U S A
Channelrhodopsins are light-gated ion channels widely used to control neuronal firing with light (optogenetics). We report two previously unknown families of anion channelrhodopsins (ACRs), one from the heterotrophic protists labyrinthulea and the ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533465ea8a14c3cd9ffa18a8fcf4c10a
https://doi.org/10.1073/pnas.2005981117
https://doi.org/10.1073/pnas.2005981117