Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Leonid G. Khaspekov"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8520 (2024)
The endogenous cannabinoid system (ECS) of the brain plays an important role in the molecular pathogenesis of Parkinson’s disease (PD). It is involved in the formation of numerous clinical manifestations of the disease by regulating the level of en
Externí odkaz:
https://doaj.org/article/4d8720cb09ae46ffb77b49cd891f3d19
Autor:
Elena V. Stelmashook, Elizaveta E. Genrikhs, Nikolay K. Isaev, Svetlana V. Novikova, Leonid G. Khaspekov
Publikováno v:
Анналы клинической и экспериментальной неврологии, Vol 14, Iss 4, Pp 54-60 (2020)
Ischaemic brain damage is a major neurobiological and medical social problem, making experimental research of the pathogenesis of cerebral ischemia and the search for ways to minimize its consequences particularly relevant. The aim of the study wa
Externí odkaz:
https://doaj.org/article/6cf2a3de7bf348c89409cf741846e4e2
Autor:
Elizaveta E. Genrikhs, Olga P. Aleksandrova, Elena V. Stelmashuk, Svetlana V. Novikova, Dmitriy N. Voronkov, Nikolay K. Isaev, Leonid G. Khaspekov
Publikováno v:
Анналы клинической и экспериментальной неврологии, Vol 13, Iss 4, Pp 38-45 (2019)
Introduction. Study of the morphofunctional neuronal development in a dissociated cerebrocortical cell culture, using modern cell technologies, is a priority in experimental neurology, which is required for successful in vitro modelling of acute and
Externí odkaz:
https://doaj.org/article/29063239c7914fbb9a92faa5a0727c49
Autor:
Leonid G. Khaspekov
Publikováno v:
Анналы клинической и экспериментальной неврологии, Vol 12, Iss 5S, Pp 70-78 (2018)
Cellular models are a very important research tool in modern neurobiology. The presented review of Russian and international literature summarizes the main data of experimental studies, conducted over the past 15 years, aimed at modeling in vitro acu
Externí odkaz:
https://doaj.org/article/1350e4d36d05458bb00b11203afb9443
Publikováno v:
Анналы клинической и экспериментальной неврологии, Vol 12, Iss 4, Pp 52-56 (2018)
Introduction. Oxidative stress is an important pathogenic factor in cerebral ischemia, which occupies one of the leading places among various forms of cerebral pathology in mortality and disability of the working-age population and is recognized as a
Externí odkaz:
https://doaj.org/article/ac64cfcb547446e888aedd41731a263a
Autor:
Leonid G. Khaspekov, Lidia E. Frumkina
Publikováno v:
Biochemistry (Moscow). 88:502-514
Publikováno v:
Bulletin of Experimental Biology and Medicine. 171:732-735
In primary dissociated hippocampal cell cultures from 18-day-old mouse embryos, streptozotocin in concentrations of 2-5 mM produced a dose-dependent cytotoxic effect on day 3 in vitro, whereas on day 11 of culturing, the neurons were resistant to str
Autor:
Leonid G Khaspekov
Publikováno v:
Biochemistry (Moscow). 86:737-745
The review summarizes the results of studies on the cellular and molecular mechanisms mediating the impact of stress on the pathogenesis of neurodegenerative brain pathologies (Alzheimer's disease, Parkinson's disease, etc.) and presents current info
Autor:
Yulia Vanyushina, E. V. Novosadova, Sergey N. Illarioshkin, Elena Arsenyeva, Stanislav A Antonov, Mikhail Bobrov, Leonid G. Khaspekov, Andrey Kobylanskiy, Vladimir V. Bezuglov, Tatyana Malova, Vyacheslav Z Tarantul, Igor Grivennikov
Publikováno v:
NeuroToxicology. 82:108-118
The prominent protective effects in diverse neuron injury paradigms exerted by cannabinoids and in particular their endogenously produced species render the endocannabinoid system a promising molecular target in the treatment of neurodegenerative dis
Autor:
I. A. Grivennikov, Sergey N. Illarioshkin, S. A. Antonov, E. V. Novosadova, L. E. Frumkina, Leonid G. Khaspekov, K. A. Kutukova, V. V. Simonova, M. V. Ivanov
Publikováno v:
Human Physiology. 46:886-894
Introduction. The study of neuronal differentiation of human induced pluripotent stem cells (iPSCs) offers wide prospects for modeling and analyzing the pathogenesis of human neurodegenerative brain diseases, screening the drugs for efficacious treat