Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Leonid Bystrykh"'
Autor:
Leonid Bystrykh
Publikováno v:
F1000Research, Vol 10 (2022)
Genome biology shows substantial progress in its analytical and computational part in the last decades. Differential gene expression is one of many computationally intense areas; it is largely developed under R programming language. Here we explain p
Externí odkaz:
https://doaj.org/article/8e0a672528594a97ab3b0ea0dca23347
Autor:
Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S. Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential and associated dormancy. Here the authors show that niche produced netrin-1 preserves HSC quiescence and self-renewal via neogenin-1, and that decline of netrin-1 prod
Externí odkaz:
https://doaj.org/article/3c2f87ae1c244f13b1b1ad0a9daad872
Autor:
Leonid Bystrykh
Publikováno v:
F1000Research, Vol 10 (2021)
Genome biology shows substantial progress in its analytical and computational part in the last decades. Differential gene expression is one of many computationally intense areas; it is largely developed under R programming language. Here we explain p
Externí odkaz:
https://doaj.org/article/0136d09b3c92492cac0b22607ae0c4fc
Autor:
Ye Yuan, Fubiao Niu, Ilja M. Nolte, Jasper Koerts, Debora de Jong, Bea Rutgers, Jan Osinga, Maria Azkanaz, Martijn Terpstra, Leonid Bystrykh, Arjan Diepstra, Lydia Visser, Agnieszka Dzikiewicz-Krawczyk, Klaas Kok, Joost Kluiver, Anke van den Berg
Publikováno v:
Cellular Physiology and Biochemistry, Vol 49, Iss 1, Pp 144-159 (2018)
Background/Aims: Classical Hodgkin lymphoma (cHL) is among the most frequent lymphoma subtypes. The tumor cells originate from crippled germinal center (GC)-B cells that escaped from apoptosis. MicroRNAs (miRNAs) play important roles in B-cell matura
Externí odkaz:
https://doaj.org/article/b7325962cc024f268c06f97f56ad5155
Autor:
Ellen Weersing, Gerald de Haan, Leonid Bystrykh, Sabrina Jacobs, Mirjam E. Belderbos, Albertina Ausema, Erik Zwart
Publikováno v:
Experimental Hematology, 91, 46-54. ELSEVIER SCIENCE INC
Clonal heterogeneity fuels leukemia evolution, therapeutic resistance, and relapse. Upfront detection of therapy-res istant leukemia clones at diagnosis may allow adaptation of treatment and prevention of relapse, but this is hampered by a paucity of
Autor:
Leonid Bystrykh, Sabrina Jacobs, Albertina Ausema, Mirjam E. Belderbos, Maaike J Kingma, Ellen Weersing, Gerald de Haan, Yasmine A S El Menshawi, Erik Zwart
Publikováno v:
Leukemia
Leukemia, 34(6), 1669-1674. Nature Publishing Group
Leukemia, 34(6), 1669-1674. Nature Publishing Group
Autor:
Gerald de Haan, Ellen Weersing, Albertina Ausema, Sabrina Jacobs, Erik Zwart, Leonid Bystrykh, Taco Koster, Mirjam E. Belderbos
Publikováno v:
Biology of Blood and Marrow Transplantation, 26(1), 16-25. ELSEVIER SCIENCE INC
Umbilical cord blood (UCB) provides an alternative source of hematopoietic stem cells (HSCs) for allogeneic transplantation. Administration of sufficient donor HSCs is critical to restore recipient hematopoiesis and to maintain long-term polyclonal b
Autor:
Leonid Bystrykh, Ellen Weersing, Alexander Bak Dinitzen, Albertina Ausema, Arthur Flohr Svendsen, Roza Cengiz, Danielle Luinenburg, Gerald de Haan
Publikováno v:
Experimental Hematology, 94, 47-59.e5. ELSEVIER SCIENCE INC
MicroRNAs (miRs) are small noncoding RNAs that regulate gene expression posttranscriptionally by binding to the 30 untranslated regions of their target mRNAs. The evolutionarily conserved microRNA-125a (miR-125a) is highly expressed in both murine an
Autor:
Karin Klauke, Ellen Weersing, Sonja Buisman, Hein Schepers, Leonid Bystrykh, Seka Lazare, Gerald de Haan, Yulia Skokova, Albertina Dethmers-Ausema, Erik Zwart, Raymond A. Poot, Johannes Jung, Mike R. Dekker, Franziska Hammerl, Susanne M. Kooistra
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1906-1918.e8 (2019)
Cell reports, 26(7), 1906-1918.e8. CELL PRESS
Cell Reports, 26(7), 1906-+. Cell Press
Cell reports, 26(7), 1906-1918.e8. CELL PRESS
Cell Reports, 26(7), 1906-+. Cell Press
Summary: In this study, we demonstrate that, among all five CBX Polycomb proteins, only CBX7 possesses the ability to control self-renewal of human hematopoietic stem and progenitor cells (HSPCs). Xenotransplantation of CBX7-overexpressing HSPCs resu
Publikováno v:
Methods in Molecular Biology, 317-344
STARTPAGE=317;ENDPAGE=344;TITLE=Methods in Molecular Biology
Leukemia Stem Cells ISBN: 9781071608098
STARTPAGE=317;ENDPAGE=344;TITLE=Methods in Molecular Biology
Leukemia Stem Cells ISBN: 9781071608098
Cellular barcoding is a relatively simple method that allows quantitative assessment of the clonal dynamics of normal, nonmalignant hematopoietic stem cells and of leukemia. Cellular barcodes are (semi-)random synthetic DNA sequences of a fixed lengt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918f1156708b28a1240ee792ffb967c8
https://research.rug.nl/en/publications/482b754d-ce82-4fff-bcdc-964e930579ad
https://research.rug.nl/en/publications/482b754d-ce82-4fff-bcdc-964e930579ad