Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Leonid A. Serebryannyy"'
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112534- (2023)
Summary: One of the major cellular mechanisms to ensure cellular protein homeostasis is the endoplasmic reticulum (ER) stress response. This pathway is triggered by accumulation of misfolded proteins in the ER lumen. The ER stress response is also ac
Externí odkaz:
https://doaj.org/article/2e6edf4b69434f418175323628943e45
Activation of endoplasmic reticulum stress via clustering of the inner nuclear membrane protein SUN2
SUMMARYOne of the major cellular mechanisms to ensure protein homeostasis is the endoplasmic reticulum (ER) stress response. This pathway is typically triggered by accumulation of misfolded proteins in the ER lumen. Here we describe activation of ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::615e45fc202d43aac3768268adb4475d
https://doi.org/10.1101/2021.09.14.460295
https://doi.org/10.1101/2021.09.14.460295
Autor:
Tom Misteli, Leonid A. Serebryannyy
Publikováno v:
Methods. 157:80-87
Protein-protein interactions are essential for cellular structure and function. To delineate how the intricate assembly of protein interactions contribute to cellular processes in health and disease, new methodologies that are both highly sensitive a
Autor:
Hui-Jun Yu, Leonid A Serebryannyy, Madeline Fry, Madelyne Greene, Olga Chernaya, Wen-Yang Hu, Teng-Leong Chew, Nadim Mahmud, Shrihari S Kadkol, Sarah Glover, Gail Prins, Zuzana Strakova, Primal de Lanerolle
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79776 (2013)
Many tumors are stiffer than their surrounding tissue. This increase in stiffness has been attributed, in part, to a Rho-dependent elevation of myosin II light chain phosphorylation. To characterize this mechanism further, we studied myosin light cha
Externí odkaz:
https://doaj.org/article/b7cdede7dfa544b09dc154618a68221a
Autor:
Tom Misteli, Leonid A. Serebryannyy
Publikováno v:
The Journal of Cell Biology
Serebryannyy and Misteli provide a perspective on how protein sequestration at the inner nuclear membrane and nuclear lamina might influence aging.
Despite the extensive description of numerous molecular changes associated with aging, insights i
Despite the extensive description of numerous molecular changes associated with aging, insights i
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 821:111714
The presence of actin in the nucleus has historically been a highly contentious issue. It is now, however, well accepted that actin has physiologically important roles in the nucleus. In this Review, we describe the evolution of our thinking about ac
Autor:
Sigal Shachar, Varun Sood, Carmen Adriaens, Elizabeth H. Finn, Gianluca Pegoraro, Tom Misteli, Sandra Vidak, Leonid A. Serebryannyy, Nard Kubben, Andria C. Schibler, Pawel Trzaskoma, Marina Feric, Karen J. Meaburn
Publikováno v:
Histochemistry and cell biology. 150(6)
The past decades have provided remarkable insights into how the eukaryotic cell nucleus and the genome within it are organized. The combined use of imaging, biochemistry and molecular biology approaches has revealed several basic principles of nuclea
The nuclear envelope (NE) is an essential cellular structure that contributes to nuclear stability, organization, and function. Mutations in NE-associated proteins result in a myriad of pathologies with widely diverse clinical manifestations, ages of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6dd612931edc9b91ce76b1ba0f6aef6
α-Catenin is an F-actin-binding protein widely recognized for its role in cell—cell adhesion. However, a growing body of literature indicates α-catenin is also a nuclear protein. In this study, we show that α-catenin is able to modulate the sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7bd526be7bdc50970f0366b6da8301
https://europepmc.org/articles/PMC5450192/
https://europepmc.org/articles/PMC5450192/
Autor:
Hui-Jun Yu, Alexander Yemelyanov, Steven T. Kosak, Leonid A. Serebryannyy, Annette S. Flozak, Cara J. Gottardi, Primal deLanerolle, Rebecca L. Daugherty
Publikováno v:
Proceedings of the National Academy of Sciences. 111:5260-5265
α-Catenin (α-cat) is an actin-binding protein required for cell-cell cohesion. Although this adhesive function for α-cat is well appreciated, cells contain a substantial amount of nonjunctional α-cat that may be used for other functions. We show