Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Leonid A. Sazanov"'
Autor:
Ziyu Zhao, Irene Vercellino, Jana Knoppová, Roman Sobotka, James W. Murray, Peter J. Nixon, Leonid A. Sazanov, Josef Komenda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Robust oxygenic photosynthesis requires a suite of accessory factors to ensure efficient assembly and repair of the oxygen-evolving photosystem two (PSII) complex. The highly conserved Ycf48 assembly factor binds to the newly synthesized D1
Externí odkaz:
https://doaj.org/article/f3a7c23139374b9fa10bec39b14337af
Autor:
David Molina-Granada, Emiliano González-Vioque, Marris G. Dibley, Raquel Cabrera-Pérez, Antoni Vallbona-Garcia, Javier Torres-Torronteras, Leonid A. Sazanov, Michael T. Ryan, Yolanda Cámara, Ramon Martí
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Mitochondrial dGTP is mostly bound to an accessory subunit of complex I of the mitochondrial respiratory chain, which may reveal a mechanism linking mitochondrial dNTP availability and oxidative metabolism.
Externí odkaz:
https://doaj.org/article/c2e314fb4cc24c139f22530a243441eb
Autor:
Javier Gutiérrez-Fernández, Karol Kaszuba, Gurdeep S. Minhas, Rozbeh Baradaran, Margherita Tambalo, David T. Gallagher, Leonid A. Sazanov
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Complex I (NADH:ubiquinone oxidoreductase) is the first enzyme of the respiratory chain in bacteria and mitochondria. Here, the authors present cryo-EM and crystal structures of T. thermophilus complex I in different conformational states and further
Externí odkaz:
https://doaj.org/article/2865989836bc44c684807dba957f46af
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102139- (2021)
Summary: Cryo-EM grid preparation is an important bottleneck in protein structure determination, especially for membrane proteins, typically requiring screening of a large number of conditions. We systematically investigated the effects of buffer com
Externí odkaz:
https://doaj.org/article/32f56a293a794a51a73fb2e587044993
Autor:
Leonid A. Sazanov, Irene Vercellino
Publikováno v:
Nature Reviews Molecular Cell Biology. 23:141-161
The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It comprises five enzymatic complexes and two mobile electron carriers that work in a mitochondrial respiratory chain. By coupling the oxidation of reducing equival
Autor:
Irene Vercellino, Leonid A. Sazanov
Publikováno v:
Nature. 598:364-367
The enzymes of the mitochondrial electron transport chain are key players of cell metabolism. Despite being active when isolated, in vivo they associate into supercomplexes1, whose precise role is debated. Supercomplexes CIII2CIV1-2 (refs. 2,3), CICI
Autor:
Ziyu Zhao, Irene Vercellino, Jana Knoppová, Roman Sobotka, James W. Murray, Peter J. Nixon, Leonid A. Sazanov, Josef Komenda
Robust oxygenic photosynthesis requires a suite of accessory factors to ensure efficient assembly and repair of the oxygen-evolving photosystem two (PSII) complex. The highly conserved Ycf48 assembly factor binds to the newly synthesized D1 reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d212e265983b91c81f050d311816f5ff
https://doi.org/10.1101/2022.10.16.512410
https://doi.org/10.1101/2022.10.16.512410
Autor:
Marilyn R. Gunner, Abhishek Singharoy, Chitrak Gupta, Umesh Khaniya, François Dehez, Christophe Chipot, Mrinal Shekhar, Chun Kit Chan, Leonid A. Sazanov
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2020, 142 (20), pp.9220-9230. ⟨10.1021/jacs.9b13450⟩
Journal of the American Chemical Society, American Chemical Society, 2020, 142 (20), pp.9220-9230. ⟨10.1021/jacs.9b13450⟩
The mitochondrial respiratory chain, formed by five protein complexes, utilizes energy from catabolic processes to synthesize ATP. Complex I, the first and the largest protein complex of the chain, harvests electrons from NADH to reduce quinone, whil
Autor:
Domen Kampjut, Leonid A. Sazanov
Publikováno v:
Current opinion in structural biology. 74
Complex I is one of the major respiratory complexes, conserved from bacteria to mammals. It oxidises NADH, reduces quinone and pumps protons across the membrane, thus playing a central role in the oxidative energy metabolism. In this review we discus
Autor:
Irene, Vercellino, Leonid A, Sazanov
Publikováno v:
Nature reviews. Molecular cell biology. 23(2)
The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It comprises five enzymatic complexes and two mobile electron carriers that work in a mitochondrial respiratory chain. By coupling the oxidation of reducing equival