Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Leonid A, Shemchuk"'
1
Akademický článek
3,3′-(Phenylmethylene)bis(1-ethyl-3,4-dihydro-1H-2,1-benzothiazine-2,2,4-trione): single-crystal X-ray diffraction study, quantum-chemical calculations and Hirshfeld surface analysis
Autor: Mariia O. Shyshkina, Dmitry A. Lega, Liudmyla M. Shemchuk, Irina L. Starchikova, Leonid A. Shemchuk
Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 79, Iss 4, Pp 349-355 (2023)
The title compound, C27H26N2O6S2, possesses potential antimicrobial, analgesic, and anti-inflammatory activity. This compound has three tautomeric forms, which relative energies were estimated with quantum-chemical calculations. All these tautomers (
Externí odkaz: https://doaj.org/article/de6e55d4db494fbe819a26e2d95d750d
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2
Akademický článek
1,2-Benzoxathiin-4(3H)-one 2,2-dioxide – an underinvestigated building block with a high synthetic and pharmacological potential: synthesis, chemical properties, biological activity
Autor: Halyna V. Hryhoriv, Dmitry A. Lega, Leonid A. Shemchuk
Publikováno v: Журнал органічної та фармацевтичної хімії, Vol 19, Iss 2, Pp 4-28 (2021)
Aim. To analyze the available literature data on the methods of synthesis, chemical transformations and the biological activity of derivatives containing a sultone core – 1,2-benzoxathiin-4(3H)-one 2,2-dioxide – and to show the possibilities of t
Externí odkaz: https://doaj.org/article/19898b8f12f14e5c98e3eec86cf9aab0
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3
Akademický článek
2-Amino-4-(4-chloro-1-ethyl-2,2-dioxo-1H-benzo[c][1,2]thiazin-3-yl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile: single-crystal X-ray diffraction study and Hirshfeld surface analysis
Autor: Mariia O. Shyshkina, Dmitry A. Lega, Volodymyr D. Goryachiy, Ludmila M. Shemchuk, Dmitriy V. Levashov, Leonid A. Shemchuk
Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 3, Pp 294-297 (2021)
In the title compound, C22H22ClN3O4S, which has potential non-steroidal anti-inflammatory activity, the benzothiazine and cyclohexenone rings both adopt a distorted sofa conformation while the 4H-pyrane ring adopts a very flattened sofa conformation.
Externí odkaz: https://doaj.org/article/e8cfcfde46694bc59415e7c1f871829f
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4
Akademický článek
Chemical transformations of new mono- and bis-derivatives of spiroindol-3,3’-pyrrolo[3,4-c]pyrrole based on bis-maleiminides and the study of the microbiological activity of the compounds synthesized
Autor: Yevheniia I. Siumka, Konstantin M. Sytnik, Dmitriy V. Levashov, Tamara V. Spychak, Vladimir D. Horiachyi, Leonid A. Shemchuk
Publikováno v: Журнал органічної та фармацевтичної хімії, Vol 17, Iss 4, Pp 44-52 (2019)
Aim. To synthesize new derivatives based on hexamethylene(ethylene)-N,N’-bis(spiroindole-3,3’-pyrrolo-[3,4-c]pyrrole-2a,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trions) and 1’-(m-phenylene-N-maleimidido)-2a’,5a’-dihydro-1’H- spiroindole-
Externí odkaz: https://doaj.org/article/eb27c5a3f35f4c7b9eaf3f56163fcbee
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7
2-Amino-4-(4-chloro-1-ethyl-2,2-dioxo-1H-benzo[c][1,2]thiazin-3-yl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile: single-crystal X-ray diffraction study and Hirshfeld surface analysis
Autor: Leonid A. Shemchuk, Mariia O. Shyshkina, Volodymyr D Goryachiy, Dmitriy V Levashov, Dmitry A. Lega, Ludmila M Shemchuk
Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 3, Pp 294-297 (2021)
Acta Crystallographica Section E: Crystallographic Communications
The mol­ecular and crystal structures were studied and a Hirshfeld surface analysis undertaken for the title benzo­thia­zine derivative, which has potential non-steroidal anti-inflammatory activity.
In the title compound, C22H22ClN3O4S, which
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2f5384e02881a64aaffe26a7c93774
https://doi.org/10.1107/s2056989021002085
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8
Synthesis of novel spiro-condensed 2-amino-4H-pyrans based on 1,2-benzoxathiin-4(3H)-one 2,2-dioxide
Autor: Ewa Wieczorek-Dziurla, Lucjusz Zaprutko, Andrzej Gzella, Galina V. Grygoriv, Leonid A. Shemchuk, Dmitry A. Lega, Valentine P. Chernykh
Publikováno v: Chemistry of Heterocyclic Compounds. 55:254-260
A series of new spiro-condensed 2-amino-4H-pyrans were synthesized by three-component interaction of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide, malononitrile, and cyclic carbonyls in moderate to high yields. This is one of the first examples of 1,2-benz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc8de5809ca533c9cb991e6b8cd4cb1a
https://doi.org/10.1007/s10593-019-02450-4
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