Výsledky vyhledávání - "Leonid, Gaidukov"

Akademický článek

A synthetic transcription platform for programmable gene expression in mammalian cells

Autor: William C. W. Chen, Leonid Gaidukov, Yong Lai, Ming-Ru Wu, Jicong Cao, Michael J. Gutbrod, Gigi C. G. Choi, Rachel P. Utomo, Ying-Chou Chen, Liliana Wroblewska, Manolis Kellis, Lin Zhang, Ron Weiss, Timothy K. Lu

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Precise and scalable regulation of gene expression in mammalian cells is challenging. Here, the authors created a highly tunable CRISPR-based synthetic transcription system for programmable control of mammalian gene expression and cellular activity.

Externí odkaz: https://doaj.org/article/310dc9b5a9a34df28dfb75c848485687

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Table S3 from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Reagents and antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0cc52ff5f90d222f6c91fd94d9fb5d
https://doi.org/10.1158/1535-7163.22520857.v1

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Data from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

The promise of IL12 as a cancer treatment has yet to be fulfilled with multiple tested approaches being limited by unwanted systemic exposure and unpredictable pharmacology. To address these limitations, we generated exoIL12, a novel, engineered exos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48f064854755ca4ed6549b6b5758945
https://doi.org/10.1158/1535-7163.c.6542815.v1

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Supplementary Table 1 from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Mean Cytokine Values in Cynomolgus Plasma After Subcutaneous Dosing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72abef236439adc462be2e495a07859
https://doi.org/10.1158/1535-7163.22520860.v1

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Supplementary Data Table 2 from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Fold-change Cytokine Values in Cynomolgus Plasma After Subcutaneous Dosing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565f93cee3c4ea09b46e8867aafda435
https://doi.org/10.1158/1535-7163.22520869.v1

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Supplementary Figure from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Figures S1 through S6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c5b51e812ca6bddaccbe1b538f459a
https://doi.org/10.1158/1535-7163.22520863

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20201229pdtedSupplementaryFigures.pdf from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

20201229pdtedSupplementaryFigures.pdf from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187f061226a25f50c15b215a72a23107
https://doi.org/10.1158/1535-7163.22520872.v1

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A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties

Publikováno v: Mol Ther

Extracellular vesicles (EVs) are an important intercellular communication system facilitating the transfer of macromolecules between cells. Delivery of exogenous cargo tethered to the EV surface or packaged inside the lumen are key strategies for gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbabea1bba95f566b0264c85c6b11c8
https://doi.org/10.1016/j.ymthe.2021.01.020

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Akademický článek

The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activitys⃞

Autor: Leonid Gaidukov, Dan S. Tawfik

Publikováno v: Journal of Lipid Research, Vol 48, Iss 7, Pp 1637-1646 (2007)

Serum paraoxonase (PON1) is a lipolactonase that associates with HDL-apolipoprotein A-I (HDL-apoA-I) and thereby plays a role in the prevention of atherosclerosis. Current sera tests make use of promiscuous substrates and provide no indications regar

Externí odkaz: https://doaj.org/article/58cfe64895224c779b4a6d2a58656fb9

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Akademický článek

The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol effluxs⃞

Autor: Leonid Gaidukov, Mira Rosenblat, Michael Aviram, Dan S. Tawfik

Publikováno v: Journal of Lipid Research, Vol 47, Iss 11, Pp 2492-2502 (2006)

Serum paraoxonase (PON1) is a HDL-associated enzyme exhibiting potentially antiatherogenic properties. Here, we examined the common PON1-192R/Q human polymorphism. Despite numerous studies, the effect of this polymorphism on the antiatherogenic poten

Externí odkaz: https://doaj.org/article/8bc9112a32ba42468c290d4c5fe15403

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