A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry

Autor: Anh Phuong Luu, Zhenlan Yao, Sangeetha Ramachandran, Stephanie A. Azzopardi, Linde A. Miles, William M. Schneider, H.-Heinrich Hoffmann, Leonia Bozzacco, Gustavo Garcia, Danyang Gong, Robert Damoiseaux, Hengli Tang, Kouki Morizono, Charles M. Rudin, Ren Sun, Vaithilingaraja Arumugaswami, John T. Poirier, Margaret R. MacDonald, Charles M. Rice, Melody M. H. Li

Publikováno v: Viruses, Vol 13, Iss 11, p 2113 (2021)

Zika virus (ZIKV) is a re-emerging flavivirus that has caused large-scale epidemics. Infection during pregnancy can lead to neurologic developmental abnormalities in children. There is no approved vaccine or therapy for ZIKV. To uncover cellular path

Externí odkaz: https://doaj.org/article/2f3d203580654a47b1222b3bf06f5e6f

TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP).

Autor: Melody M H Li, Zerlina Lau, Pamela Cheung, Eduardo G Aguilar, William M Schneider, Leonia Bozzacco, Henrik Molina, Eugen Buehler, Akinori Takaoka, Charles M Rice, Dan P Felsenfeld, Margaret R MacDonald

Publikováno v: PLoS Pathogens, Vol 13, Iss 1, p e1006145 (2017)

The host factor and interferon (IFN)-stimulated gene (ISG) product, zinc-finger antiviral protein (ZAP), inhibits a number of diverse viruses by usurping and intersecting with multiple cellular pathways. To elucidate its antiviral mechanism, we perfo

Externí odkaz: https://doaj.org/article/a8efea74f386440099de31c0b39f4517

A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry

Autor: Zhenlan Yao, Charles M. Rice, Danyang Gong, Melody M. H. Li, John T. Poirier, William M. Schneider, Stephanie A. Azzopardi, Hengli Tang, Margaret R. MacDonald, H.-Heinrich Hoffmann, Leonia Bozzacco, Sangeetha Ramachandran, Ren Sun, Robert Damoiseaux, Charles M. Rudin, Anh Phuong Luu, Linde A. Miles, Gustavo Garcia, Vaithilingaraja Arumugaswami, Kouki Morizono

Publikováno v: Viruses, Vol 13, Iss 2113, p 2113 (2021)
Viruses
Volume 13
Issue 11

Zika virus (ZIKV) is a re-emerging flavivirus that has caused large-scale epidemics. Infection during pregnancy can lead to neurologic developmental abnormalities in children. There is no approved vaccine or therapy for ZIKV. To uncover cellular path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950c559b45ff6ad07841b01ce8415257
https://www.mdpi.com/1999-4915/13/11/2113

Risk of Zika microcephaly correlates with features of maternal antibodies

Autor: Priscilla C. Olsen, Rubens Belfort, Juliana A Lima, Charles M. Rice, Gustavo B. S Carvalho, David H. O’Connor, Heather A. Simmons, Michael Gale, Rebekah I. Keesler, Gracinda Archanjo, Stephanie A. Azzopardi, Antônio Raimundo Pinto de Almeida, Gustavo Carvalho, Isadora Cristina de Siqueira, Dawn M. Dudley, Federico Costa, Thiago Y. Oliveira, Pedro Fernando da Costa Vasconcelos, Anne D. Lewis, Lois M. A. Colgin, Adeolu Aromolaran, Anna Gazumyan, Jennifer Tisoncik-Go, Gielson Almeida do Sacramento, Kristina M. Adams Waldorf, Manoel Sarno, Ana P Alcântara, Nicole N. Haese, Albert I. Ko, Alec J. Hirsch, Elsio A. Wunder, Meredith A. Kelleher, Bruno de Paula Freitas, Jessica L. Smith, Mitermayer G. Reis, Davide F. Robbiani, Margaret R. MacDonald, Laksmi Rajagopal, Dina Daltro, Dennis Schaefer-Babajew, Ricardo Khouri, Rosemary J. Steinbach, Leonia Bozzacco, Qiao Wang, Daniele Freitas Henriques, Antonio E. Frias, Michel C. Nussenzweig, Lark L. Coffey, Adriana Mattos, Nivison Nery, Andres Mejia, Jaqueline S. Cruz, Licia Moreira, Kleber Pimentel, Daniel N. Streblow, João R. M. de Almeida, Victoria H. J. Roberts, Koen K. A. Van Rompay, Mateus Santana do Rosário, Katiaci Araujo

Publikováno v: Repositório Digital do Instituto Evandro Chagas (Patuá)
Instituto Evandro Chagas (IEC)
instacron:IEC
The Journal of Experimental Medicine

ZIKV infection during pregnancy causes microcephaly, but not all neonates are affected. This study shows that features of the maternal antibodies correlate with the risk of ZIKV-associated microcephaly.
Zika virus (ZIKV) infection during pregnan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acee0b48342e649f77b09066df4275d5
https://doi.org/10.1084/jem.20191061

A histone-like motif in yellow fever virus contributes to viral replication

Autor: Carolina Adura, Alan Gerber, Alexander Tarakhovsky, Dinshaw J. Patel, Diego Mourao, Benjamin A Garcia, Henrik Molina, Matthew R. Paul, Inmaculada Rioja, Charles M. Rice, Natarajan V. Bhanu, Leticia A.M. Carneiro, Robert G. Roeder, Brian D. Dill, Thomas L. Carroll, Gerard Joberty, Rab K. Prinjha, Shoudeng Chen, Leonia Bozzacco, Uwe Schaefer, Margaret R. MacDonald

Publikováno v: bioRxiv, 2020. Cold Spring Harbor Laboratory Press
Mourao, D, Chen, S, Schaefer, U, Bozzacco, L, Carneiro, L A, Gerber, A, Adura, C, Dill, B D, Molina, H, Carroll, T, Paul, M, Bhanu, N V, Garcia, B A, Joberty, G, Rioja, I, Prinjha, R K, Roeder, R G, Rice, C M, MacDonald, M R, Patel, D J & Tarakhovsky, A 2020, ' A histone-like motif in yellow fever virus contributes to viral replication ', bioRxiv, vol. 2020 . https://doi.org/10.1101/2020.05.05.078782

The mimicry of host proteins by viruses contributes to their ability to suppress antiviral immunity and hijack host biosynthetic machinery1. Host adaptation to evade this exploitation depends on host protein functional redundancy2. Non-redundant, ess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cf35bd9001f77ec669a28d3ab24aa3
https://research.vu.nl/en/publications/f6715f1a-4a11-4342-a462-0d6a0020ccd0