Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Leonhard Held"'
Publikováno v:
Royal Society Open Science, Vol 11, Iss 8 (2024)
Statistical significance of both the original and the replication study is a commonly used criterion to assess replication attempts, also known as the two-trials rule in drug development. However, replication studies are sometimes conducted although
Externí odkaz:
https://doaj.org/article/20f4f889a3b2406480fc2f27ce8a0781
Publikováno v:
BMJ Medicine, Vol 3, Iss 1 (2024)
Objective To explore how design emulation and population differences relate to variation in results between randomised controlled trials (RCT) and non-randomised real world evidence (RWE) studies, based on the RCT-DUPLICATE initiative (Randomised, Co
Externí odkaz:
https://doaj.org/article/9e3119892f264705bccfe5525e3af4e3
Publikováno v:
F1000Research, Vol 12 (2024)
Background The quality of COVID-19 preprints should be considered with great care, as their contents can influence public policy. Surprisingly little has been done to calibrate the public’s evaluation of preprints and their contents. The PRECHECK p
Externí odkaz:
https://doaj.org/article/5cd69120d4654f10be1962fd1af789ee
Autor:
Maximilian Mastall, Patrick Roth, Andrea Bink, Angela Fischer Maranta, Heinz Läubli, Andreas Felix Hottinger, Thomas Hundsberger, Denis Migliorini, Adrian Ochsenbein, Katharina Seystahl, Lukas Imbach, Tibor Hortobagyi, Leonhard Held, Michael Weller, Hans-Georg Wirsching
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background Glioblastoma is the most common and most aggressive malignant primary brain tumor in adults. Glioblastoma cells synthesize and secrete large quantities of the excitatory neurotransmitter glutamate, driving epilepsy, neuronal death
Externí odkaz:
https://doaj.org/article/e53ab1e863984c64a3b65cb1d93195ef
Publikováno v:
eLife, Vol 12 (2024)
In several large-scale replication projects, statistically non-significant results in both the original and the replication study have been interpreted as a ‘replication success.’ Here, we discuss the logical problems with this approach: Non-sign
Externí odkaz:
https://doaj.org/article/b5bf0b5914bd4a17a96b39b0ebcf9a5f
Autor:
Natascha Ingrid Drude, Lorena Martinez-Gamboa, Meggie Danziger, Anja Collazo, Silke Kniffert, Janine Wiebach, Gustav Nilsonne, Frank Konietschke, Sophie K. Piper, Samuel Pawel, Charlotte Micheloud, Leonhard Held, Florian Frommlet, Daniel Segelcke, Esther M. Pogatzki-Zahn, Bernhard Voelkl, Tim Friede, Edgar Brunner, Astrid Dempfle, Bernhard Haller, Marie Juliane Jung, Lars Björn Riecken, Hans-Georg Kuhn, Matthias Tenbusch, Lina Maria Serna Higuita, Edmond J. Remarque, Servan Luciano Grüninger-Egli, Katrin Manske, Sebastian Kobold, Marion Rivalan, Lisa Wedekind, Juliane C. Wilcke, Anne-Laure Boulesteix, Marcus W. Meinhardt, Rainer Spanagel, Simone Hettmer, Irene von Lüttichau, Carla Regina, Ulrich Dirnagl, Ulf Toelch
Publikováno v:
Translational Medicine Communications, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Clinical translation from bench to bedside often remains challenging even despite promising preclinical evidence. Among many drivers like biological complexity or poorly understood disease pathology, preclinical evidence often lacks desired
Externí odkaz:
https://doaj.org/article/bf47b97f5e2949fb928a3da8d60cd224
Autor:
Christoph Martin Rüegger, Dominic Gascho, Peter Karl Bode, Elisabeth Bruder, Christian Haslinger, Steffen Ross, Kevin Schmid, Claudia Knöpfli, Lisa J. Hofer, Leonhard Held, Rosa Maria Martinez, Hans Ulrich Bucher, for the Virtopsy Study Group
Publikováno v:
BMC Pediatrics, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Post-mortem imaging has been suggested as an alternative to conventional autopsy in the prenatal and postnatal periods. Noninvasive autopsies do not provide tissue for histological examination, which may limit their clinical value
Externí odkaz:
https://doaj.org/article/7b86e61e846b4edc9613d044d22f9d44
Publikováno v:
BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-4 (2022)
Abstract We examine the concept of Bayesian Additional Evidence (BAE) recently proposed by Sondhi et al. We derive simple closed-form expressions for BAE and compare its properties with other methods for assessing findings in the light of new evidenc
Externí odkaz:
https://doaj.org/article/f109ea9009b6478987b46bfea6a1cc1a
Autor:
Simon Schwab, Perrine Janiaud, Michael Dayan, Valentin Amrhein, Radoslaw Panczak, Patricia M Palagi, Lars G Hemkens, Meike Ramon, Nicolas Rothen, Stephen Senn, Eva Furrer, Leonhard Held
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010139 (2022)
Externí odkaz:
https://doaj.org/article/55270207f96848ac9e2470cad59e30de
Autor:
Aline Wolfensberger, Lauren Clack, von Felten Stefanie, Katharina Kusejko, Mirjam Faes Hesse, Werner Jakob, Dirk Saleschus, Marie-Theres Meier, Roger Kouyos, Leonhard Held, Hugo Sax
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Hospital acquired pneumonia (HAP) is divided in two distinct groups, ventilator-associated pneumonia (VAP) and non-ventilator-associated HAP (nvHAP). Although nvHAP occurs more frequently than VAP and results in similar mortality
Externí odkaz:
https://doaj.org/article/ebad063f766747f1b2a7279440bbe2e5