Zobrazeno 1 - 10
of 848
pro vyhledávání: '"Leong, Lim"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Synaptic Vesicle Glycoprotein 2C (SV2C), characterized by its selective expression in discrete brain regions such as the midbrain, has recently emerged as a promising player in Parkinson’s Disease (PD) – a debilitating neurodegenerative disorder
Externí odkaz:
https://doaj.org/article/f74d3ec6ddc0448aa7d7ac27d8cb2611
Autor:
Wenli Cui, Jing Yang, Chuanyun Tu, Ziting Zhang, Huifang Zhao, Yan Qiao, Yanqiu Li, Wulin Yang, Kah-Leong Lim, Quanhong Ma, Chengwu Zhang, Li Lu
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-15 (2024)
Abstract Seipin is one key mediator of lipid metabolism that is highly expressed in adipose tissues as well as in the brain. Lack of Seipin gene, Bscl2, leads to not only severe lipid metabolic disorders but also cognitive impairments and motor disab
Externí odkaz:
https://doaj.org/article/ac9a3cbcf6594d67ac8d3f56c6f4cfd4
Autor:
Teddy J. W. Tng, Barbara Wing Yan Wong, Esther H. Y. Sim, Eng King Tan, Wilson W. B. Goh, Kah-Leong Lim
Publikováno v:
Translational Medicine Communications, Vol 9, Iss 1, Pp 1-21 (2024)
Abstract Parkinson’s disease (PD) is a prevalent neurodegenerative disorder affecting millions of elderly individuals worldwide. Clinically, PD is diagnosed based on the presentation of motoric symptoms. Other methods such as F-DOPA PET scan or α-
Externí odkaz:
https://doaj.org/article/1f023a8c5dfc4c8085e7636fbddf049a
Publikováno v:
Journal of Orthopaedic Reports, Vol 3, Iss 1, Pp 100315- (2024)
Background: Intraarticular fractures of the distal ulna rarely occur as an isolated phenomenon. We describe one such case with distal radioulnar joint disruption in a 13-year-old child who sustained an injury to his dominant right wrist following a f
Externí odkaz:
https://doaj.org/article/18767bc97c044e23a2b3f1e305bbb16e
Autor:
Pazhanichamy Kalailingam, Khalilatul‐Hanisah Mohd‐Kahliab, SoFong Cam Ngan, Ranjith Iyappan, Evelin Melekh, Tian Lu, Gan Wei Zien, Bhargy Sharma, Tiannan Guo, Adam J MacNeil, Rebecca EK MacPherson, Evangelia Litsa Tsiani, Deborah D O'Leary, Kah Leong Lim, I Hsin Su, Yong‐Gui Gao, A Mark Richards, Raj N Kalaria, Christopher P Chen, Neil E McCarthy, Siu Kwan Sze
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-16 (2023)
Abstract Aging results from the accumulation of molecular damage that impairs normal biochemical processes. We previously reported that age‐linked damage to amino acid sequence NGR (Asn‐Gly‐Arg) results in “gain‐of‐function” conformatio
Externí odkaz:
https://doaj.org/article/0e78e068254840989c041da6a4477442
Autor:
Dylan Hong Zheng Koh, Tomoki Naito, Minyoung Na, Yee Jie Yeap, Pritisha Rozario, Franklin L. Zhong, Kah-Leong Lim, Yasunori Saheki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the distribution of cellular cholesterol is associated with numerous diseases, including neurodegenerative disorders. While regulated transport of a spe
Externí odkaz:
https://doaj.org/article/91c41d6838114740a6485960bdefe6bb
Autor:
Jing Yang, Na Yang, Huifang Zhao, Yan Qiao, Yanqiu Li, Chunfang Wang, Kah-Leong Lim, Chengwu Zhang, Wulin Yang, Li Lu
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Background Lipodystrophy-associated metabolic disorders caused by Seipin deficiency lead to not only severe lipodystrophy but also neurological disorders. However, the underlying mechanism of Seipin deficiency-induced neuropathy is not well
Externí odkaz:
https://doaj.org/article/81a5fa7d3a8f4d5f9e79172579110faf
Autor:
Joseph D. Quick, Cristian Silva, Jia Hui Wong, Kah Leong Lim, Richard Reynolds, Anna M. Barron, Jialiu Zeng, Chih Hung Lo
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Microglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their active phagocytic capability. Be
Externí odkaz:
https://doaj.org/article/bc395be4598848258372b3681dfdadc4
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Pollen tube growth involves coordinated energy fluxes between plastids, the cytosol, and mitochondria. Here using ratiometric biosensors, the authors delineate energy flux in growing Arabidopsis pollen tubes by monitoring ATP, NADPH and the NADH/NAD
Externí odkaz:
https://doaj.org/article/e709a4ef43624b5d8a49050aee7b3d58
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-18 (2022)
Abstract Background Aberrant aggregation of α-synuclein (α-syn) is a key pathological feature of Parkinson’s disease (PD), but the precise role of intestinal α-syn in the progression of PD is unclear. In a number of genetic Drosophila models of
Externí odkaz:
https://doaj.org/article/e56eb6790d5d42038861326d9d0a3a33