A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors

Autor: Imogen J. Swift, Rosa Rademakers, NiCole Finch, Matt Baker, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Giacomina Rossi, Matthis Synofzik, Carlo Wilke, David Mengel, Caroline Graff, Leonel T. Takada, Raquel Sánchez-Valle, Anna Antonell, Daniela Galimberti, Chiara Fenoglio, Maria Serpente, Marina Arcaro, Stefanie Schreiber, Stefan Vielhaber, Philipp Arndt, Isabel Santana, Maria Rosario Almeida, Fermín Moreno, Myriam Barandiaran, Alazne Gabilondo, Johannes Stubert, Estrella Gómez-Tortosa, Pablo Agüero, M. José Sainz, Tomohito Gohda, Maki Murakoshi, Nozomu Kamei, Sarah Kittel-Schneider, Andreas Reif, Johannes Weigl, Jinlong Jian, Chuanju Liu, Ginette Serrero, Thomas Greither, Gerit Theil, Ebba Lohmann, Stefano Gazzina, Silvia Bagnoli, Giovanni Coppola, Amalia Bruni, Mirja Quante, Wieland Kiess, Andreas Hiemisch, Anne Jurkutat, Matthew S. Block, Aaron M. Carlson, Geir Bråthen, Sigrid Botne Sando, Gøril Rolfseng Grøntvedt, Camilla Lauridsen, Amanda Heslegrave, Carolin Heller, Emily Abel, Alba Gómez-Núñez, Roger Puey, Andrea Arighi, Enmanuela Rotondo, Lize C. Jiskoot, Lieke H. H. Meeter, João Durães, Marisa Lima, Miguel Tábuas-Pereira, João Lemos, Bradley Boeve, Ronald C. Petersen, Dennis W. Dickson, Neill R. Graff-Radford, Isabelle LeBer, Leila Sellami, Foudil Lamari, Fabienne Clot, Barbara Borroni, Valentina Cantoni, Jasmine Rivolta, Alberto Lleó, Juan Fortea, Daniel Alcolea, Ignacio Illán-Gala, Lucie Andres-Cerezo, Philip Van Damme, Jordi Clarimon, Petra Steinacker, Emily Feneberg, Markus Otto, Emma L. van der Ende, John C. van Swieten, Harro Seelaar, Henrik Zetterberg, Aitana Sogorb-Esteve, Jonathan D. Rohrer

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)

Abstract Background Pathogenic heterozygous mutations in the progranulin gene (GRN) are a key cause of frontotemporal dementia (FTD), leading to significantly reduced biofluid concentrations of the progranulin protein (PGRN). This has led to a number

Externí odkaz: https://doaj.org/article/1d7c751ac55c494a90e49ef788756561

Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: a cross sectional observational studyResearch in context

Autor: Marcelo Adrián Maito, Hernando Santamaría-García, Sebastián Moguilner, Katherine L. Possin, María E. Godoy, José Alberto Avila-Funes, María I. Behrens, Ignacio L. Brusco, Martín A. Bruno, Juan F. Cardona, Nilton Custodio, Adolfo M. García, Shireen Javandel, Francisco Lopera, Diana L. Matallana, Bruce Miller, Maira Okada de Oliveira, Stefanie D. Pina-Escudero, Andrea Slachevsky, Ana L. Sosa Ortiz, Leonel T. Takada, Enzo Tagliazuchi, Victor Valcour, Jennifer S. Yokoyama, Agustín Ibañez

Publikováno v: The Lancet Regional Health. Americas, Vol 17, Iss , Pp 100387- (2023)

Summary: Background: Global brain health initiatives call for improving methods for the diagnosis of Alzheimer's disease (AD) and frontotemporal dementia (FTD) in underrepresented populations. However, diagnostic procedures in upper-middle-income cou

Externí odkaz: https://doaj.org/article/4ec51759945747fbaaabc9db03fca988

The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science

Autor: Agustin Ibanez, Jennifer S. Yokoyama, Katherine L. Possin, Diana Matallana, Francisco Lopera, Ricardo Nitrini, Leonel T. Takada, Nilton Custodio, Ana Luisa Sosa Ortiz, José Alberto Avila-Funes, Maria Isabel Behrens, Andrea Slachevsky, Richard M. Myers, J. Nicholas Cochran, Luis Ignacio Brusco, Martin A. Bruno, Sonia M. D. Brucki, Stefanie Danielle Pina-Escudero, Maira Okada de Oliveira, Patricio Donnelly Kehoe, Adolfo M. Garcia, Juan Felipe Cardona, Hernando Santamaria-Garcia, Sebastian Moguilner, Claudia Duran-Aniotz, Enzo Tagliazucchi, Marcelo Maito, Erika Mariana Longoria Ibarrola, Maritza Pintado-Caipa, Maria Eugenia Godoy, Vera Bakman, Shireen Javandel, Kenneth S. Kosik, Victor Valcour, Bruce L. Miller

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems

Externí odkaz: https://doaj.org/article/a2e4fdf9c3cc48448e116e091fd05800

Perspectives and challenges in patient stratification in Alzheimer's disease

Autor: Carla Abdelnour, Federica Agosta, Marco Bozzali, Bertrand Fougère, Atsushi Iwata, Ramin Nilforooshan, Leonel T. Takada, Félix Viñuela, Martin Traber

Background Patient stratification is the division of a patient population into distinct subgroups based on the presence or absence of particular disease characteristics. As patient stratification can be used to account for the underlying pathology of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0801957b9b355e8226b5126e7e8e1c8
https://hdl.handle.net/10668/20360

Dementia in Latin America: Paving the way toward a regional action plan

Autor: Raffaele Ferrari, Oscar L. Lopez, Leonel T. Takada, José Alberto Avila-Funes, Katherine L. Possin, Marcio Luiz Figueredo Balthazar, Carlos Cano-Gutierrez, Fábio Henrique de Gobbi Porto, David Orozco, Letícia Lessa Mansur, Jeronimo Martin Ramirez, André Luiz Rodrigues Palmeira, Adolfo M. García, Juan de Jesús Llibre, Henry Engler, Elisa de Paula França Resende, Silvia Kochen, Sebastian Moguilner, Lingani Mbakile-Mahlanza, Renata Kochhann, Antônio Lúcio Teixeira, Dominic Trépel, Maritza Pintado Caipa, Patricia Cogram, Yakeel T. Quiroz, Agustín Ibáñez, Ronnielly Melo Tavares, Maira Tonidandel Barbosa, Andrea Slachevsky, Roberta Diehl Rodriguez, Gonzalo A. Farías, Laís Fajersztajn, Bárbara Costa Beber, Maira Okada de Oliveira, Norberto Anizio Ferreira Frota, David Lira, Patricio Fuentes, Laura Morelli, Patricia Lillo, Paulo Caramelli, Renata Eloah de Lucena Ferretti-Rebustini, Stefanie Danielle Piña Escudero, Cecilia Serrano, Sonia Maria Dozzi Brucki, Heather M. Snyder, Sandra Baez, Ana Luisa Sosa, Alejandra Guerrero Barragan, Adelina Comas, Rosa Montesinos, Paulo Henrique Ferreira Bertolucci, Juan F. Cardona, Ioannis Tarnanas, Jerusa Smid, Lea T. Grinberg, Fernanda G. De Felice, Mario A. Parra, Christian Gonzalez-Billault, Cecilia Gonzalez Campo, Eliane Correa Miotto, David Huepe, Jose Manuel Santacruz-Escudero, Maria Aparecida Camargos Bicalho, Bruce L. Miller, P. Solis, Claudia K. Suemoto, Lissette Duque Peñailillo, Patricia J. Garcia, Marcia Lorena Fagundes Chaves, Lucas Porcello Schilling, Rodrigo B. Serafim, Claudia Ramos, Hernando Santamaría-García, Fabricio Joao Pio, Alyne Mendonca Marques Ton, Ignacio F. Mata, Irene Maier, Leonardo Cruz de Souza, Felipe A. Court, Lucas Sedeño, Myriam de la Cruz, Mônica Sanches Yassuda, Jenifer Yokoyama, Jorge J. Llibre Guerra, Fabricio Ferreira de Oliveira, Serggio Lanata, Nilton Custodio, Ricardo Nitrini, Andres Damian, Kenneth S. Kosik, Julián Bustin, Graciela Muniz-Terrera, Ceres Ferretti, Ivan Aprahamian, Diana Matallana, Olivier Piguet, Marcio Soto-Añari, Fiona Kumfor, Sergio T. Ferreira, Francisco Lopera, Mirna Lie Hosogi, Luis Arnoldo Muñoz-Nevárez

Publikováno v: Alzheimer's & Dementia
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Parra, M A, Baez, S, Sedeño, L, Gonzalez Campo, C, Santamaría-garcía, H, Aprahamian, I, Bertolucci, P H, Bustin, J, Camargos Bicalho, M A, Cano-gutierrez, C, Caramelli, P, Chaves, M L F, Cogram, P, Beber, B C, Court, F A, Souza, L C, Custodio, N, Damian, A, De La Cruz, M, Diehl Rodriguez, R, Brucki, S M D, Fajersztajn, L, Farías, G A, De Felice, F G, Ferrari, R, De Oliveira, F F, Ferreira, S T, Ferretti, C, Figueredo Balthazar, M L, Ferreira Frota, N A, Fuentes, P, García, A M, Garcia, P J, De Gobbi Porto, F H, Duque Peñailillo, L, Engler, H W, Maier, I, Mata, I F, Gonzalez-billault, C, Lopez, O L, Morelli, L, Nitrini, R, Quiroz, Y T, Guerrero Barragan, A, Huepe, D, Pio, F J, Suemoto, C K, Kochhann, R, Kochen, S, Kumfor, F, Lanata, S, Miller, B, Mansur, L L, Hosogi, M L, Lillo, P, Llibre Guerra, J, Lira, D, Lopera, F, Comas, A, Avila-funes, J A, Sosa, A L, Ramos, C, Resende, E D P F, Snyder, H M, Tarnanas, I, Yokoyama, J, Llibre, J, Cardona, J F, Possin, K, Kosik, K S, Montesinos, R, Moguilner, S, Solis, P C L, Ferretti-rebustini, R E D L, Ramirez, J M, Matallana, D, Mbakile-mahlanza, L, Marques Ton, A M, Tavares, R M, Miotto, E C, Muniz Terrera, G, Muñoz-nevárez, L A, Orozco, D, Okada De Oliveira, M, Piguet, O, Pintado Caipa, M, Piña Escudero, S D, Schilling, L P, Rodrigues Palmeira, A L, Yassuda, M S, Santacruz-escudero, J M, Serafim, R B, Smid, J, Slachevsky, A, Serrano, C, Soto-añari, M, Takada, L T, Grinberg, L T, Teixeira, A L, Barbosa, M T, Trépel, D & Ibanez, A 2020, ' Dementia in Latin America: Paving the way toward a regional action plan ', Alzheimer's & Dementia, vol. 17, no. 2, pp. 295-313 . https://doi.org/10.1002/alz.12202, https://doi.org/10.1002/alz.v17.2

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collabora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e82e77ac218d72613df5a753778cac8
http://europepmc.org/articles/PMC7984223