Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Leonel Prado-Lourenco"'
Autor:
Paul Mitchell, M. Elahy, Meidong Zhu, Joel P. Mackay, Mark J. Raftery, Yue Li, Samuel J. Adamson, Jessica Marchand, Ahmad M. N. Alhendi, Fernando S. Santiago, François Barnat, Andrew Chang, Enoch Chan, Lorna Wilkinson-White, Levon M. Khachigian, Ben J. Wu, Mei-Chun Yeh, Shafqat Inam, Rohan David Joyce, Karen Viaud-Quentric, Sebastian M. Marcuccio, Nandan P. Deshpande, Jim Sockler, Leonel Prado-Lourenco
Publikováno v:
Science Advances
A thermostable drug suppresses a pERK-FosB/ΔFosB-VCAM-1 axis, endothelial activation, angiogenesis, and retinal permeability.
Vascular permeability and angiogenesis underpin neovascular age-related macular degeneration and diabetic retinopathy.
Vascular permeability and angiogenesis underpin neovascular age-related macular degeneration and diabetic retinopathy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafc7006bb0af9a9ff4b384040a5edda
https://doi.org/10.1126/sciadv.aaz7815
https://doi.org/10.1126/sciadv.aaz7815
Autor:
Leonel Prado-Lourenco, Stéphanie Bornes, Amandine Bastide, Jason S. Iacovoni, Hervé Prats, Anne-Catherine Prats, Eric Lacazette, Christian Touriol, Catherine Zanibellato
Publikováno v:
Circulation Research
Circulation Research, 2007, 100 (3), pp.305-8. ⟨10.1161/01.RES.0000258873.08041.c9⟩
Circulation Research, 2007, 100 (3), pp.305-8. ⟨10.1161/01.RES.0000258873.08041.c9⟩
International audience; Vascular endothelial growth factor-A (VEGF), a powerful factor involved in vasculogenesis and angiogenesis, is translationally regulated through 2 independent internal ribosome entry sites (IRESs A and B). IRESs enable an mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413a762262767acddc56c23dc859ce08
https://doi.org/10.1161/01.res.0000258873.08041.c9
https://doi.org/10.1161/01.res.0000258873.08041.c9
Autor:
Thomas S. Griffith, Carmine Gentile, Mary M. Kavurma, Jayant Ravindran, Amanda W. S. Yeung, Shane R. Thomas, Nor Saadah Muhammad Azahri, Belinda A. Di Bartolo, Thuan Thai, Siân P. Cartland, Leonel Prado-Lourenco
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Tumor necrosis factor–related apoptosis‐inducing ligand ( TRAIL ) has the ability to inhibit angiogenesis by inducing endothelial cell death, as well as being able to promote pro‐angiogenic activity in vitro. These seemingly opposite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd8cd373a750e7471f5dc9d0c17ebcc
https://doi.org/10.1161/jaha.115.002527
https://doi.org/10.1161/jaha.115.002527
Autor:
Leonel Prado-Lourenco, Amanda W. S. Yeung, Thuan Thai, Shane R. Thomas, Sian Cartland, Mary M. Kavurma, Nor Saadah M. Azahri, Belinda A. Di Bartolo
Publikováno v:
Circulation. 130
Background: Angiogenesis and neovascularization are essential processes that follow ischemia insults. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) not only induces endothelial cell (EC) death and inhibits angiogenesis, but al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db9398affc1a997277554d132e2818ad
https://doi.org/10.1161/circ.130.suppl_2.18060
https://doi.org/10.1161/circ.130.suppl_2.18060
Autor:
Bassem M. Shoucri, Seth G. Thacker, Praveen Sethupathy, Kerry-Anne Rye, Philip J. Barter, Michael G. Levin, Leonel Prado-Lourenco, Fatiha Tabet, Luisa F. Cuesta Torres, Carrie B. Wiese, Claire Catherinet, Kasey C. Vickers, Gilles Lambert, Alan T. Remaley
High-density lipoproteins (HDL) have many biological functions, including reducing endothelial activation and adhesion molecule expression. We recently reported that HDL transport and deliver functional microRNAs (miRNA). Here we show that HDL suppre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf65c1e322680e610b5445efeb52bef
Autor:
Ying Lu, James G. Kench, Mathew A. Vadas, Christopher N. Hahn, Joshua Moses, Anna Tsykin, Leonel Prado-Lourenco, Nham Tran, Louise L. Dunn, Jennifer Young, Angelina J. Lay, Gregory J. Goodall, Nicholas A. Shackel, Geoffrey W. McCaughan, Levon M. Khachigian, Ka Ka Ting, Ilana Lichtenstein, Jia Li, Jennifer R. Gamble, Thorleif Moller, Philip A. Gregory, Martin K.C. Ng
Publikováno v:
Scopus-Elsevier
Cellular junctions are essential to the normal functioning of the endothelium and control angiogenesis, tissue leak, and inflammation. From a screen of micro RNAs (miRNAs) altered in in vitro angiogenesis, we selected a subset predicted to target jun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e3dcf2b038457b38ef58174ae426cb
https://pubmed.ncbi.nlm.nih.gov/24009229
https://pubmed.ncbi.nlm.nih.gov/24009229
Publikováno v:
Angiogenesis and Vascularisation ISBN: 9783709114278
Immediate-early genes are those that are rapidly induced in response to a cellular stimulus in the absence of protein synthesis and can influence the biology and pathobiology of the cell. These span transcription factors, cytokines, growth factors, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3d4ec32c502f3dc101b554373db7aa
https://doi.org/10.1007/978-3-7091-1428-5_7
https://doi.org/10.1007/978-3-7091-1428-5_7
Autor:
Levon M. Khachigian, Miles P. Davenport, Ross StC Barnetson, Fergal J. Moloney, Tak Wah Wong, Gary M. Halliday, Fernando S. Santiago, Colin N. Chesterman, Douglas J. Francis, Margaret Patrikakis, Beng H. Chong, Bo Wang, Ghassan J. Maghzal, Roland Stocker, Graham J. Lieschke, Christopher R. Parish, Hong Cai, Leonel Prado-Lourenco
Publikováno v:
Science translational medicine. 4(139)
Worldwide, one in three cancers is skin-related, with increasing incidence in many populations. Here, we demonstrate the capacity of a DNAzyme-targeting c-jun mRNA, Dz13, to inhibit growth of two common skin cancer types-basal cell and squamous cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52c159d0ac11716210c4d87a14e453b
https://pubmed.ncbi.nlm.nih.gov/22850785
https://pubmed.ncbi.nlm.nih.gov/22850785
Autor:
Jeffrey Chan, Levon M. Khachigian, Belinda A. Di Bartolo, Mary M. Kavurma, Martin R. Bennett, Leonel Prado-Lourenco
Publikováno v:
Circulation research. 106(6)
Rationale : TRAIL (tumor necrosis factor–related apoptosis-inducing ligand) is well reported as an inducer of apoptosis in tumor models; however, its role and function in vivo in atherosclerosis and vascular injury has not been established. Objecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e668b58c646bcd1f59c584eaf1140d57
https://pubmed.ncbi.nlm.nih.gov/20150555
https://pubmed.ncbi.nlm.nih.gov/20150555
Autor:
Charles Neveu, Audrey Rayssac, Anne-Catherine Prats, Jean-François Arnal, Mélanie Pucelle, Loic Van Den Berghe, Xavier Chaufour, Leonel Prado-Lourenco
Publikováno v:
Molecular Therapy
Molecular Therapy, Cell Press, 2009, epub ahead of print. ⟨10.1038/mt.2009.211⟩
Molecular Therapy, 2009, epub ahead of print. ⟨10.1038/mt.2009.211⟩
Molecular Therapy, Cell Press, 2009, epub ahead of print. ⟨10.1038/mt.2009.211⟩
Molecular Therapy, 2009, epub ahead of print. ⟨10.1038/mt.2009.211⟩
International audience; Due to the lack of an adequate conventional therapy against lower limb ischemia, gene transfer for therapeutic angiogenesis is seen as an attractive alternative. However, the possibility of side effects, due to the expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff7f951bd2cdc680fe76b4116937064
https://www.hal.inserm.fr/inserm-00419435
https://www.hal.inserm.fr/inserm-00419435