Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Leonel Munoz-Sagredo"'
Autor:
Ilaria Rosso, Corey Jones-Weinert, Francesca Rossiello, Matteo Cabrini, Silvia Brambillasca, Leonel Munoz-Sagredo, Zeno Lavagnino, Emanuele Martini, Enzo Tedone, Massimiliano Garre’, Julio Aguado, Dario Parazzoli, Marina Mione, Jerry W. Shay, Ciro Mercurio, Fabrizio d’Adda di Fagagna
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism activated in ~10–15% of cancers, characterized by telomeric damage. Telomeric damage-induced long non-coding RNAs (dilncRNAs) are transcribed at dysfunctional t
Externí odkaz:
https://doaj.org/article/96aecb24e77f4ab3b16b729a382e090c
Autor:
Romina J. Walter, Steffen J. Sonnentag, Leonel Munoz-Sagredo, Melanie Merkel, Ludovic Richert, Felix Bunert, Yvonne M. Heneka, Thomas Loustau, Michael Hodder, Rachel A. Ridgway, Owen J. Sansom, Yves Mely, Ulrich Rothbauer, Mark Schmitt, Véronique Orian-Rousseau
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-16 (2022)
Abstract Enhancement of Wnt signaling is fundamental for stem cell function during intestinal regeneration. Molecular modules control Wnt activity by regulating signal transduction. CD44 is such a positive regulator and a Wnt target gene. While highl
Externí odkaz:
https://doaj.org/article/ba60973a08064619990c359bff0a4f13
Autor:
Tong Xu, Mathijs Verhagen, Rosalie Joosten, Wenjie Sun, Andrea Sacchetti, Leonel Munoz Sagredo, Véronique Orian-Rousseau, Riccardo Fodde
Publikováno v:
eLife, Vol 11 (2022)
Phenotypic plasticity allows carcinoma cells to transiently acquire the quasi-mesenchymal features necessary to detach from the primary mass and proceed along the invasion-metastasis cascade. A broad spectrum of epigenetic mechanisms is likely to cau
Externí odkaz:
https://doaj.org/article/b2b52f669ba54817b60881937191c705
Autor:
Tong Xu, Mathijs Verhagen, Rosalie Joosten, Wenjie Sun, Andrea Sacchetti, Leonel Munoz Sagredo, Véronique Orian-Rousseau, Riccardo Fodde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f15d1b16e592f5fce9819e2ed04a2c32
https://doi.org/10.7554/elife.82006.sa2
https://doi.org/10.7554/elife.82006.sa2
Autor:
Tanja Nicole Hartmann, Karolin Streule, Carsten Müller-Tidow, Romina Judith Walter, Richard Greil, Leonel Munoz-Sagredo, Patricia Muschong, Miguel L. Concha, Julia Christine Gutjahr, Elisabeth Bayer, Xiaobing Yu, Véronique Orian-Rousseau
Publikováno v:
Blood. 138:1067-1080
Acute myeloid leukemia (AML) has a poor prognosis under the current standard of care. In recent years, venetoclax, a BCL-2 inhibitor, was approved to treat patients who are ineligible for intensive induction chemotherapy. However, complete remission
Autor:
Mijanur Rahaman Molla, Leonel Munoz Sagredo, Pavel A. Levkin, Markus Drechsler, Shraddha Chakraborty, Véronique Orian−Rousseau
Publikováno v:
Bioconjugate Chemistry. 31:852-860
Transcriptional inhibition by small interfering RNA (siRNA) delivery using synthetic transfection agents eliminates the subsequent risk of introducing mutations in relevant genes, as opposed to viral vectors. However, synthetic vectors with comparabl
Autor:
Romina J, Walter, Steffen J, Sonnentag, Leonel, Munoz-Sagredo, Melanie, Merkel, Ludovic, Richert, Felix, Bunert, Yvonne M, Heneka, Thomas, Loustau, Michael, Hodder, Rachel A, Ridgway, Owen J, Sansom, Yves, Mely, Ulrich, Rothbauer, Mark, Schmitt, Véronique, Orian-Rousseau
Publikováno v:
Cell deathdisease. 13(2)
Enhancement of Wnt signaling is fundamental for stem cell function during intestinal regeneration. Molecular modules control Wnt activity by regulating signal transduction. CD44 is such a positive regulator and a Wnt target gene. While highly express
Autor:
Leonel Munoz Sagredo, Shimrit Avraham, Véronique Orian-Rousseau, Haguy Wolfenson, Abhishek Mukherjee, Tamar Geiger, Dvir Shechter, Yuval Shaked, Michal Harel, Elad Prinz, David Loven
Publikováno v:
Cells
Cells, Vol 9, Iss 2269, p 2269 (2020)
Volume 9
Issue 10
Cells, 9 (10), 2269
Cells, Vol 9, Iss 2269, p 2269 (2020)
Volume 9
Issue 10
Cells, 9 (10), 2269
Tumor cell heterogeneity is primarily dictated by mutational changes, sometimes leading to clones that undergo a metastatic switch. However, little is known about tumor heterogeneity following chemotherapy perturbation. Here we studied the possible i
Autor:
Viviana Anelli, Anita Ordas, Susanne Kneitz, Leonel Munoz Sagredo, Victor Gourain, Manfred Schartl, Annemarie H. Meijer, Marina Mione
Publikováno v:
Frontiers in genetics, 9, Artikel-Nr.: 675
Frontiers in Genetics
Frontiers in Genetics, Vol 9 (2018)
Frontiers in Genetics
Frontiers in Genetics, Vol 9 (2018)
Ras genes are among the most commonly mutated genes in human cancer; yet our understanding of their oncogenic activity at the molecular mechanistic level is incomplete. To identify downstream events that mediate ras-induced cellular transformation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccbdc6fd65c87b5afd142cc0c7c4268
https://publikationen.bibliothek.kit.edu/1000089055
https://publikationen.bibliothek.kit.edu/1000089055