Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Leonel E. Rojo"'
Autor:
Claudio Acuña-Castillo, Mabel Vidal, Eva Vallejos-Vidal, Roberto Luraschi, Carlos Barrera-Avalos, Ailen Inostroza-Molina, Sonia Molina-Cabrera, Daniel Valdes, Carolina Schafer, Kevin Maisey, Mónica Imarai, Rodrigo Vera, Sergio Vargas, Leonel E. Rojo, Elías Leiva-Salcedo, Alejandro Escobar, Sebastián Reyes-Cerpa, Alexis Gaete, Ricardo Palma-Vejares, Dante Travisany, Claudio Torres, Felipe E. Reyes-López, Ana María Sandino
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e24419- (2024)
Background: As the COVID-19 pandemic persists, infections continue to surge globally. Presently, the most effective strategies to curb the disease and prevent outbreaks involve fostering immunity, promptly identifying positive cases, and ensuring the
Externí odkaz:
https://doaj.org/article/e88008247a6e4966a573a7575e0dfe3e
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Alzheimer’s disease (AD) is the most common form of neurodegenerative disease and disability in the elderly; it is estimated to account for 60%–70% of all cases of dementia worldwide. The most relevant mechanistic hypothesis to explain AD symptom
Externí odkaz:
https://doaj.org/article/a1ae811f86274bf9a796163d8ff5c6ee
Autor:
Víctor Andrade, Maylin Wong-Guerra, Nicole Cortés, Gabriela Pastor, Andrea González, Camila Calfío, Leonardo Guzmán-Martínez, Leonardo P. Navarrete, Nicolas Ramos-Escobar, Inelia Morales, Rocío Santander, Juan Andrades-Lagos, Mitchell Bacho, Leonel E. Rojo, Ricardo Benjamín Maccioni
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 960 (2023)
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder without a cure, despite the enormous number of investigations and therapeutic approaches. AD is a consequence of microglial responses to “damage signals”, such as aggregate
Externí odkaz:
https://doaj.org/article/7bf836ffbde647c6888e94019d7aea65
Autor:
Carlos Barrera-Avalos, Pedro Briceño, Daniel Valdés, Mónica Imarai, Elías Leiva-Salcedo, Leonel E. Rojo, Luis A. Milla, Juan Pablo Huidobro-Toro, Claudia Robles-Planells, Alejandro Escobar, Francesco Di Virgilio, Gabriel Morón, Daniela Sauma, Claudio Acuña-Castillo
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103520- (2021)
Summary: T cell activation requires the processing and presentation of antigenic peptides in the context of a major histocompatibility complex (MHC complex). Cross-dressing is a non-conventional antigen presentation mechanism, involving the transfer
Externí odkaz:
https://doaj.org/article/128cfe10d0e34ee580248c3e368befc7
Autor:
Francisco Díaz-Castro, Matías Monsalves-Álvarez, Leonel E. Rojo, Andrea del Campo, Rodrigo Troncoso
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic exposure to cortisol is as
Externí odkaz:
https://doaj.org/article/a0b83766d2ae4c58aede0b4a45cf919f
Autor:
Claudia Robles-Planells, Giselle Sánchez-Guerrero, Carlos Barrera-Avalos, Silvia Matiacevich, Leonel E. Rojo, Jorge Pavez, Edison Salas-Huenuleo, Marcelo J. Kogan, Alejandro Escobar, Luis A. Milla, Ricardo Fernandez, Mónica Imarai, Eugenio Spencer, Juan Pablo Huidobro-Toro, Claudio Acuña-Castillo
Publikováno v:
Mediators of Inflammation, Vol 2020 (2020)
Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation and immunogenic cell death
Externí odkaz:
https://doaj.org/article/6ea9183ca04c481c9a90f59db9b9426e
Autor:
Andrea del Campo, Catalina Salamanca, Angelo Fajardo, Francisco Díaz-Castro, Catalina Bustos, Camila Calfío, Rodrigo Troncoso, Edgar R. Pastene-Navarrete, Claudio Acuna-Castillo, Luis A. Milla, Carlos A. Villarroel, Francisco A. Cubillos, Mario Aranda, Leonel E. Rojo
Publikováno v:
Molecules, Vol 26, Iss 20, p 6149 (2021)
Type 2 diabetes and obesity are major problems worldwide and dietary polyphenols have shown efficacy to ameliorate signs of these diseases. Anthocyanins from berries display potent antioxidants and protect against weight gain and insulin resistance i
Externí odkaz:
https://doaj.org/article/e21d257cd4e1492a8cb382eb628ae34b
Autor:
Claudia Robles-Planells, Sofia A. Michelson, Javier Mena, Daniela Escrig, Juan L. Rojas, Giselle Sanchez-Guerrero, Ronny Hernández, Carlos Barrera-Avalos, Leonel E. Rojo, Daniela Sauma, Alexis M. Kalergis, Mónica Imarai, Ricardo Fernández, Carolina A. Robles, Elías Leiva-Salcedo, Rocio Santander, Alejandro Escobar, Claudio Acuña-Castillo
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive clinical effects of this therapy have been associated to increased Th17 response and
Externí odkaz:
https://doaj.org/article/1ee59b96ff124ad68a8a218a86c6a7ef
Autor:
Andrea del Campo, Catalina Bustos, Carolina Mascayano, Claudio Acuña-Castillo, Rodrigo Troncoso, Leonel E. Rojo
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There are limited prophylactic inte
Externí odkaz:
https://doaj.org/article/39b07853024348e3914181144796d1b3
Autor:
Jonathan Morales, Carlos Barrera-Avalos, Carlos Castro, Stephanie Castillo, Claudio Barrientos, Claudia Robles-Planells, Ximena López, Ernesto Torres, Margarita Montoya, Marcelo Cortez-San Martín, Denise Riquelme, Alejandro Escobar, Ricardo Fernández, Mónica Imarai, Daniela Sauma, Leonel E. Rojo, Elias Leiva-Salcedo, Claudio Acuña-Castillo
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Antigen cross-presentation is a crucial step in the assembly of an antitumor immune response leading to activation of naïve CD8 T cells. This process has been extensively used in clinical trials, in which dendritic cells generated in vitro are loade
Externí odkaz:
https://doaj.org/article/51ff5d8be73c4a808e35262395de0beb