A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors

Autor: Imogen J. Swift, Rosa Rademakers, NiCole Finch, Matt Baker, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Giacomina Rossi, Matthis Synofzik, Carlo Wilke, David Mengel, Caroline Graff, Leonel T. Takada, Raquel Sánchez-Valle, Anna Antonell, Daniela Galimberti, Chiara Fenoglio, Maria Serpente, Marina Arcaro, Stefanie Schreiber, Stefan Vielhaber, Philipp Arndt, Isabel Santana, Maria Rosario Almeida, Fermín Moreno, Myriam Barandiaran, Alazne Gabilondo, Johannes Stubert, Estrella Gómez-Tortosa, Pablo Agüero, M. José Sainz, Tomohito Gohda, Maki Murakoshi, Nozomu Kamei, Sarah Kittel-Schneider, Andreas Reif, Johannes Weigl, Jinlong Jian, Chuanju Liu, Ginette Serrero, Thomas Greither, Gerit Theil, Ebba Lohmann, Stefano Gazzina, Silvia Bagnoli, Giovanni Coppola, Amalia Bruni, Mirja Quante, Wieland Kiess, Andreas Hiemisch, Anne Jurkutat, Matthew S. Block, Aaron M. Carlson, Geir Bråthen, Sigrid Botne Sando, Gøril Rolfseng Grøntvedt, Camilla Lauridsen, Amanda Heslegrave, Carolin Heller, Emily Abel, Alba Gómez-Núñez, Roger Puey, Andrea Arighi, Enmanuela Rotondo, Lize C. Jiskoot, Lieke H. H. Meeter, João Durães, Marisa Lima, Miguel Tábuas-Pereira, João Lemos, Bradley Boeve, Ronald C. Petersen, Dennis W. Dickson, Neill R. Graff-Radford, Isabelle LeBer, Leila Sellami, Foudil Lamari, Fabienne Clot, Barbara Borroni, Valentina Cantoni, Jasmine Rivolta, Alberto Lleó, Juan Fortea, Daniel Alcolea, Ignacio Illán-Gala, Lucie Andres-Cerezo, Philip Van Damme, Jordi Clarimon, Petra Steinacker, Emily Feneberg, Markus Otto, Emma L. van der Ende, John C. van Swieten, Harro Seelaar, Henrik Zetterberg, Aitana Sogorb-Esteve, Jonathan D. Rohrer

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)

Abstract Background Pathogenic heterozygous mutations in the progranulin gene (GRN) are a key cause of frontotemporal dementia (FTD), leading to significantly reduced biofluid concentrations of the progranulin protein (PGRN). This has led to a number

Externí odkaz: https://doaj.org/article/1d7c751ac55c494a90e49ef788756561

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Perspectives and challenges in patient stratification in Alzheimer’s disease

Autor: Carla Abdelnour, Federica Agosta, Marco Bozzali, Bertrand Fougère, Atsushi Iwata, Ramin Nilforooshan, Leonel T. Takada, Félix Viñuela, Martin Traber

Publikováno v: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)

Abstract Background Patient stratification is the division of a patient population into distinct subgroups based on the presence or absence of particular disease characteristics. As patient stratification can be used to account for the underlying pat

Externí odkaz: https://doaj.org/article/0963a2d230184043a8bac0dc179f9674

Griffiths phase and long-range correlations in a biologically motivated V1 model

Autor: Girardi-Schappo, Mauricio, Bortolotto, Germano S., Gonsalves, Jheniffer J., Pinto, Leonel T., Tragtenberg, Marcelo H. R.

Publikováno v: Scientific Reports 6, Article number: 29561 (2016)

Activity in the brain propagates as waves of firing neurons, namely avalanches. These waves' size and duration distributions have been experimentally shown to display a stable power-law profile, long-range correlations and $1/f^{b}$ power spectrum \t

Externí odkaz: http://arxiv.org/abs/1509.08954

Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries

Autor: Claudia Duran-Aniotz, Paulina Orellana, Tomas Leon Rodriguez, Fernando Henriquez, Victoria Cabello, María F. Aguirre-Pinto, Tamara Escobedo, Leonel T. Takada, Stefanie D. Pina-Escudero, Oscar Lopez, Jennifer S. Yokoyama, Agustin Ibanez, Mario A. Parra, Andrea Slachevsky

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Frontotemporal dementia (FTD) includes a group of clinically, genetically, and pathologically heterogeneous neurodegenerative disorders, affecting the fronto-insular-temporal regions of the brain. Clinically, FTD is characterized by progressive defic

Externí odkaz: https://doaj.org/article/8eff1edc95a64035ba74af1ffa80104b