Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leonardus J, van der Aa"'
Autor:
Johan F.J. Engbersen, Raymond M. Schiffelers, Gert Storm, Pieter Vader, Leonardus J. van der Aa
Publikováno v:
Pharmaceutical Research
Pharmaceutical research, 29(2), 352-361. Springer
Pharmaceutical research, 29(2), 352-361. Springer
Purpose Use of RNA interference as novel therapeutic strategy is hampered by inefficient delivery of its mediator, siRNA, to target cells. Cationic polymers have been thoroughly investigated for this purpose but often display unfavorable characterist
Autor:
Arwyn Tomos Jones, Leonardus J. van der Aa, Martin Piest, Dries Vercauteren, Kevin Braeckmans, Monerah Al Soraj, Johan F.J. Engbersen, Stefaan C. De Smedt
Publikováno v:
Biomaterials, 32(11), 3072-3084. Elsevier
Extensive research is currently performed on designing safe and efficient non-viral carriers for gene delivery. To increase their efficiency, it is essential to have a thorough understanding of the mechanisms involved in cellular attachment, internal
Publikováno v:
Macromolecular Rapid Communications. 32:321-325
Poly(amidoamine)s (PAAs) have received significant attention due to their good biocompatibility and fast biodegradation profile which gives these polymers high potential in biomedical applications. Conventional synthesis of PAAs via aza-type Michael
Publikováno v:
Macromolecules, 40(4), 1165-1173. American Chemical Society
Various vinyl sulfone functionalized dextrans (dex-VS) (Mn,dextran = 14K or 31K) with degrees of substitution (DS) ranging from 2 to 22 were conveniently prepared by a one-pot synthesis procedure at room temperature. This procedure involved reaction
Autor:
Pieter Vader, Gert Storm, Raymond M. Schiffelers, Johannes F.J. Engbersen, Leonardus J. van der Aa
Publikováno v:
Pharmaceutical research, 28(5), 1013-1022. Springer
Pharmaceutical Research
Pharmaceutical Research
Purpose RNA interference (RNAi) is a process by which small interfering RNAs (siRNA) induce sequence-specific gene silencing. Therefore, siRNA is an emerging promise as a novel therapeutic. In order to realize the high expectations for therapeutic ap
Autor:
Raymond M. Schiffelers, Pieter Vader, Leonardus J. van der Aa, Johan F.J. Engbersen, Gert Storm
Publikováno v:
Journal of controlled release, 148(1 (special issue)), 106-109. Elsevier
Efficient intracellular delivery of siRNA is a significant hurdle to its therapeutic success. For biological studies on the efficiency of carrier-mediated uptake of siRNA, quantitative determination of the amount of internalized siRNA is required. In
Publikováno v:
Macromolecular rapid communications. 32(3)
Poly(amidoamine)s (PAAs) have received significant attention due to their good biocompatibility and fast biodegradation profile which gives these polymers high potential in biomedical applications. Conventional synthesis of PAAs via aza-type Michael
Autor:
Clemens van Blitterswijk, Leonardus J. van der Aa, Theun van Veen, Jan Feijen, Zhiyuan Zhong, Christine Hiemstra, Jan de Boer, J.M. Jukes, Pieter J. Dijkstra
Publikováno v:
Tissue engineering. Part A, 16(2), 565-573. Mary Ann Liebert
Cartilage tissue engineering, in which chondrogenic cells are combined with a scaffold, is a cell-based approach to regenerate damaged cartilage. Various scaffold materials have been investigated, among which are hydrogels. Previously, we have develo
Publikováno v:
Biomacromolecules, 8(5), 1548-1556. American Chemical Society
Thiol-functionalized dextrans (dex-SH) (M(n,dextran) = 14K or 31K) with degrees of substitution (DS) ranging from 12 to 25 were synthesized and investigated for in situ hydrogel formation via Michael type addition using poly(ethylene glycol) tetra-ac
Autor:
Gert Storm, Ton N. Schumacher, Wim E. Hennink, Leonardus J. van der Aa, Koen Oosterhuis, Johan F.J. Engbersen, Jos H. Beijnen, Bastiaan Nuijen, John B. A. G. Haanen, Joost H. van den Berg
Publikováno v:
Journal of Controlled Release, 141, 234. Elsevier
Journal of controlled release, 141(2), 234-240. Elsevier
Journal of controlled release, 141(2), 234-240. Elsevier
Nanoparticle-formulated DNA vaccines hold promise for the design of in vivo vaccination platforms that target defined cell types in human skin. A variety of DNA formulations, mainly based on cationic liposomes or polymers, has been investigated to im