Výsledky vyhledávání - "Leonardo T Totola"

Akademický článek

SOCS3 Ablation in Leptin Receptor-Expressing Cells Causes Autonomic and Cardiac Dysfunctions in Middle-Aged Mice despite Improving Energy and Glucose Metabolism

Autor: João A. B. Pedroso, Ivson B. da Silva, Thais T. Zampieri, Leonardo T. Totola, Thiago S. Moreira, Ana P. T. Taniguti, Gabriela P. Diniz, Maria Luiza M. Barreto-Chaves, Jose Donato

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 12, p 6484 (2022)

Leptin resistance is a hallmark of obesity. Treatments aiming to improve leptin sensitivity are considered a promising therapeutical approach against obesity. However, leptin receptor (LepR) signaling also modulates several neurovegetative aspects, s

Externí odkaz: https://doaj.org/article/1ebc96f0690649ecbcbd7de84212cb6a

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Autoregulation of blood flow drives early hypotension in a rat model of systemic inflammation induced by bacterial lipopolysaccharide

Autor: Eduardo H Moretti, Abner C Rodrigues, Bruno V Marques, Leonardo T Totola, Caroline B Ferreira, Camila F Brito, Caroline M Matos, Filipe A da Silva, Robson A S Santos, Luciana B Lopes, Thiago S Moreira, Eliana H Akamine, Luiz A Baccala, André Fujita, Alexandre A Steiner

Publikováno v: PNAS Nexus. 2

Uncontrolled vasodilation is known to account for hypotension in the advanced stages of sepsis and other systemic inflammatory conditions, but the mechanisms of hypotension in earlier stages of such conditions are not clear. By monitoring hemodynamic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29816cf3bcff0a2cfc5f67e0ba1ce087
https://doi.org/10.1093/pnasnexus/pgad014

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Impaired chemosensory control of breathing after depletion of bulbospinal catecholaminergic neurons in rats

Autor: Leonardo T. Totola, Thiago S. Moreira, Milene R. Malheiros-Lima, Ana C. Takakura

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Bulbospinal catecholaminergic neurons located in the rostral aspect of the ventrolateral medulla (C1 neurons) or within the ventrolateral pons (A5 neurons) are involved in the regulation of blood pressure and sympathetic outflow. A stimulus that comm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76992d2165304186f8a4768c9eaf7287
https://doi.org/10.1007/s00424-017-2078-8

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Amygdala rapid kindling impairs breathing in response to chemoreflex activation

Autor: Milene R. Malheiros-Lima, Ana C. Takakura, Thiago S. Moreira, Polianna Delfino-Pereira, Norberto Garcia-Cairasco, Flávio Del Vecchio, Leonardo T. Totola, Felipe C Souza

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Temporal lobe epilepsy is often accompanied by behavioral, electroencephalographic and autonomic abnormalities. Amygdala kindling has been used as an experimental model to study epileptogenesis. Although amygdala kindling has been extensively investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fa8fb595d80b3eb6e7bd2b2f4a789a

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Impaired central respiratory chemoreflex in an experimental genetic model of epilepsy

Autor: Norberto Garcia-Cairasco, Leonardo T. Totola, Thiago S. Moreira, Ana C. Takakura, José Antônio Cortes de Oliveira

Publikováno v: The Journal of Physiology. 595:983-999

Key points It is recognized that seizures commonly cause apnoea and oxygen desaturation, but there is still a lack in the literature about the respiratory impairments observed ictally and in the post-ictal period. Respiratory disorders may involve ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ee96b82661136677b89faba7e43638d
https://doi.org/10.1113/jp272822

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Breathing responses produced by optogenetic stimulation of adrenergic C1 neurons are dependent on the connection with preBötzinger complex in rats

Autor: Milene R. Malheiros-Lima, Bryan E. Strauss, Leonardo T. Totola, Marlous G Lana, Thiago S. Moreira, Ana C. Takakura

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Optogenetic stimulation of the adrenergic C1 neurons produces cardiorespiratory activation, and selective depletion of these cells attenuates breathing responses induced by hypoxia. The preBotzinger complex (preBotC) is a group of neurons located in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f46a18c1c7cdc9d1e53a67c41a56833

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Commissural nucleus of the solitary tract regulates the antihypertensive effects elicited by moxonidine

Autor: Ana C. Takakura, Vagner Roberto Antunes, Thales B. Alves, José Vanderlei Menani, Thiago S. Moreira, Hildebrando Candido Ferreira-Neto, Eduardo Colombari, Leonardo T. Totola

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The rostral ventrolateral medulla (RVLM) contains the presympathetic neurons involved in cardiovascular regulation that has been implicated as one of the most important central sites for the antihypertensive action of moxonidine (an α2-adrenergic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9435fe54bf745b925eb1ed2b861e80

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GABA‐A receptors mediating sympathoinhibition elicited by moxonidine in rats

Autor: Thales B. Alves, Ana C. Takakura, Thiago S. Moreira, Leonardo T. Totola, Eduardo Colombari

Publikováno v: The FASEB Journal. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3ca80376487b28b41b3e24e044f259f
https://doi.org/10.1096/fasebj.26.1_supplement.1091.32

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Central chemoreceptors and neural mechanisms of cardiorespiratory control

Autor: Cleyton R. Sobrinho, Leonardo T. Totola, F.P. Zolezi, Danielle A M T Ragioto, Rosélia S. Damasceno, Thiago S. Moreira, Ana C. Takakura, Barbara Falquetto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The arterial partial pressure (P(CO)(2)) of carbon dioxide is virtually constant because of the close match between the metabolic production of this gas and its excretion via breathing. Blood gas homeostasis does not rely solely on changes in lung ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60833c9aca40aa029457f24798591dd8

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GABA mechanisms of the nucleus of the solitary tract regulates the cardiovascular and sympathetic effects of moxonidine

Autor: Leonardo T. Totola, Thales B. Alves, Eduardo Colombari, Ana C. Takakura, Thiago S. Moreira

Publikováno v: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2018-11-26T16:19:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The

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