Výsledky vyhledávání - "Leonardo Santos Ribeiro Pinto"

Dissertation/ Thesis

Influência da inibição da glicoproteína-P pela fluoxetina na disposição cinética dos enantiômeros da fexofenadina em parturientes e suas relações com a transferência placentaria

Autor: Leonardo Santos Ribeiro Pinto

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

Interações medicamentosas envolvendo a glicoproteína-P (P-gp) intestinal e placentária são determinantes na disposição cinética e transferência placentária de medicamentos durante a gestação. A fexofenadina, fármaco anti-histamínico, es

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-25092015-150930/

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Chiral Transplacental Pharmacokinetics of Fexofenadine: Impact of P-Glycoprotein Inhibitor Fluoxetine Using the Human Placental Perfusion Model

Autor: Howard Berger, Ricardo de Carvalho Cavalli, Leonardo Santos Ribeiro Pinto, Fernanda de Lima Moreira, Gideon Koren, Vera Lucia Lanchote, Priya Bapat, Angelika Lubetsky

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Fexofenadine is a well-identified in vivo probe substrate of P-glycoprotein (P-gp) and/or organic anion transporting polypeptide (OATP). This work aimed to investigate the transplacental pharmacokinetics of fexofenadine enantiomers with and without t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72a0e09c7764f93be58d6f1524846b0
https://doi.org/10.1007/s11095-021-03035-7

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Direct chiral LC-MS/MS analysis of fexofenadine enantiomers in plasma and urine with application in a maternal-fetal pharmacokinetic study

Autor: Eduardo Barbosa Coelho, Fernanda de Lima Moreira, Maria Paula Marques, Leonardo Santos Ribeiro Pinto, Vera Lucia Lanchote, Ricardo de Carvalho Cavalli, Gabriel T. do Vale

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

This study shows the development and validation of two enantioselective LC-MS/MS methods for the determination of fexofenadine in biological matrices including the elution order determination. Plasma (200 µL) or urine (50 µL) aliquots were added to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa12bb001f1288429c9d887b5631e8f
https://pubmed.ncbi.nlm.nih.gov/32311673

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Population pharmacokinetics and biodistribution of benznidazole in mice

Autor: Paula Melo de Abreu Vieira, Israel Molina, Rodrigo Correa-Oliveira, Glauco Henrique Balthazar Nardotto, Luísa Perin, Cláudia Martins Carneiro, Kátia da Silva Fonseca, Leonardo Santos Ribeiro Pinto, Thaís Fernanda Rodrigues Bastos Mendes, Beatriz Oliveira Paiva

Publikováno v: The Journal of antimicrobial chemotherapy. 75(8)

Objectives To evaluate the population pharmacokinetics of different benznidazole treatment regimens and the drug’s biodistribution in mice. Methods Two hundred mice were divided into five groups according to benznidazole dosing regimens: (1) 100 mg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daccb8d0f7b256ec861c957e823e836
https://pubmed.ncbi.nlm.nih.gov/32356873

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Pharmacokinetics of Benznidazole in Healthy Volunteers and Implications in Future Clinical Trials

Autor: M. A. Artaza, L. Perin, Adrián Sánchez-Montalvá, Leonardo Santos Ribeiro Pinto, R. Moreno, A. Esquisabel, Fernando Salvador, Israel Molina, José Luis Pedraz

Publikováno v: Antimicrobial agents and chemotherapy. 61(4)

Despite its toxicity and low efficacy in the chronic phase, benznidazole is the drug of choice in Chagas disease. Scarce information about pharmacokinetics and pharmacodynamics of benznidazole has been published. We performed a phase I, open-label, n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0496a66dc0403fae905ddd7617c5a5
https://pubmed.ncbi.nlm.nih.gov/28167552

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Examining the transplacental passage of apixaban using the dually perfused human placenta

Autor: Howard Berger, Leonardo Santos Ribeiro Pinto, Katarina Aleksa, Priya Bapat, Gideon Koren, Angelika Lubetsky, Shinya Ito

Publikováno v: Journal of thrombosis and haemostasis : JTH. 14(7)

UNLABELLED Essentials Apixaban is a novel oral anticoagulant that has not been studied in pregnant patients. Our objective was to determine the rate and extent of the placental transfer of apixaban. Apixaban rapidly crosses the ex vivo term human pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a04a3068702c4336709d7b3131d422
https://pubmed.ncbi.nlm.nih.gov/27149680

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Effect of P-gp inhibition by fluoxetine on the kinetic disposition and of fexofenadine enantiomers in parturients and their relationships with transplacental transfer

Autor: Leonardo Santos Ribeiro Pinto

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b541cd53865e9e1716cd383d4cc5682

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Rivaroxaban transfer across the dually perfused isolated human placental cotyledon

Autor: Angelika Lubetsky, Priya Bapat, Leonardo Santos Ribeiro Pinto, Howard Berger, Gideon Koren

Publikováno v: American Journal of Obstetrics and Gynecology. 213:710.e1-710.e6

Objective The purpose of this study was to determine the rate and extent of rivaroxaban transfer across the term human placenta and determine whether passive diffusion was the primary mechanism involved in this transfer. Study Design The transplacent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9d90a95d7bc7411d7956808127aad0
https://doi.org/10.1016/j.ajog.2015.06.065

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