Genomic glucocorticoid receptor effects guide acute stress-induced delayed anxiety and basolateral amygdala spine plasticity in rats

Autor: Leonardo S. Novaes, Leticia M. Bueno-de-Camargo, Amadeu Shigeo-de-Almeida, Vitor A.L. Juliano, Ki Goosens, Carolina D. Munhoz

Publikováno v: Neurobiology of Stress, Vol 28, Iss , Pp 100587- (2024)

Anxiety, a state related to anticipatory fear, can be adaptive in the face of environmental threats or stressors. However, anxiety can also become persistent and manifest as anxiety- and stress-related disorders, such as generalized anxiety or post-t

Externí odkaz: https://doaj.org/article/08cae7bfad6e4841a24ec2039615313c

Environmental enrichment prevents the late effect of acute stress-induced fear extinction deficit: the role of hippocampal AMPA-GluA1 phosphorylation

Autor: Letícia Morais Bueno-de-Camargo, Leonardo S. Novaes, Carolina Demarchi Munhoz

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The persistence of anxiety and the deficit of fear memory extinction are both phenomena related to the symptoms of a trauma-related disorder, such as post-traumatic stress disorder (PTSD). Recently we have shown that single acute restraint stress (2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423547f23ec24f5bce5201c8192ff4b0
https://doaj.org/article/ff77485ea0ba4e98a7019cefcb8f4109

Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation

Autor: Marilia B, Malta, Joelcimar, Martins, Leonardo S, Novaes, Nilton B, Dos Santos, Luciane, Sita, Rosana, Camarini, Cristoforo, Scavone, Jackson, Bittencourt, Carolina D, Munhoz

Publikováno v: Molecular neurobiology. 58(10)

The stress response is multifactorial and enrolls circuitries to build a coordinated reaction, leading to behavioral, endocrine, and autonomic changes. These changes are mainly related to the hypothalamus-pituitary-adrenal (HPA) axis activation and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24e451999359ac1f469056337513fba6
https://pubmed.ncbi.nlm.nih.gov/34213722

High dose of dexamethasone protects against EAE-induced motor deficits but impairs learning/memory in C57BL/6 mice

Autor: Carolina Demarchi Munhoz, Guilherme Dragunas, Jennifer R Rodrigues, Leonardo S. Novaes, Jean Pierre Schatzmann Peron, Nilton Nascimento Dos Santos, Rosana Camarini, Wesley Nogueira Brandão

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, 9(1). Nature Publishing Group
Scientific Reports

Multiple sclerosis (MS) is an autoimmune and neuroinflammatory disease characterized by demyelination of the Central Nervous System. Immune cells activation and release of pro-inflammatory cytokines play a crucial role in the disease modulation, deci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a122c44b4eb1f4abac21a6b95edab0
https://doi.org/10.1038/s41598-019-43217-3

Environmental enrichment prevents acute restraint stress-induced anxiety-related behavior but not changes in basolateral amygdala spine density

Autor: Ki Ann Goosens, Nilton Barreto dos Santos, Juliano Genaro Perfetto, Carolina Demarchi Munhoz, Leonardo S. Novaes

Publikováno v: Psychoneuroendocrinology. 98

Previous studies showed that acute restraint stress or transient elevation of glucocorticoid (GC) stress hormones produces emergent changes in both anxiety behavior and dendritic branches in the basolateral amygdala complex (BLA) of rats. In this wor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bb4504280ef787c89c1d0027dbc717
https://pubmed.ncbi.nlm.nih.gov/30081343